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UNC Genetics PublicationsDepartment of Genetics faculty, postdocs, students and collaborators published 12 papers during February 4th – 17th, 2024.

Cell cycle plasticity underlies fractional resistance to palbociclib in ER+/HER2- breast tumor cells. 

Zikry TM, Wolff SC, Ranek JS, Davis HM, Naugle A, Luthra N, Whitman AA, Kedziora KM, Stallaert W, Kosorok MR, Spanheimer PM, Purvis JE.

Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2309261121. doi: 10.1073/pnas.2309261121. Epub 2024 Feb 7.

PMID: 38324568

 

Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI. 

Sun Q, Rowland BT, Chen J, Mikhaylova AV, Avery C, Peters U, Lundin J, Matise T, Buyske S, Tao R, Mathias RA, Reiner AP, Auer PL, Cox NJ, Kooperberg C, Thornton TA, Raffield LM, Li Y.

Nat Commun. 2024 Feb 3;15(1):1016. doi: 10.1038/s41467-024-45135-z.

PMID: 38310129 Free PMC article.

 

A genetic association study of circulating coagulation Factor VIII and von Willebrand Factor levels. 

de Vries PS, Reventun P, Brown MR, Heath AS, Huffman JE, Le NQ, Bebo A, Brody JA, Temprano-Sagrera G, Raffield LM, Ozel AB, Thibord F, Jain D, Lewis JP, Rodriguez BAT, Pankratz N, Taylor KD, Polasek O, Chen MH, Yanek LR, Carrasquilla GD, Marioni R, Kleber ME, Trégouët DA, Yao J, Li-Gao R, Joshi PK, Trompet S, Martinez-Perez A, Ghanbari M, Howard TE, Reiner AP, Arvanitis M, Ryan KA, Bartz TM, Rudan I, Faraday N, Linneberg A, Ekunwe L, Davies G, Delgado GE, Suchon P, Guo X, Rosendaal FR, Klaric L, Noordam R, van Rooij F, Curran JE, Wheeler MM, Osburn WO, O’Connell JR, Boerwinkle E, Beswick A, Psaty BM, Kolcic I, Souto JC, Becker LC, Hansen T, Doyle MF, Harris SE, Moissl AP, Deleuze JF, Rich SS, van Hylckama Vlieg A, Campbell H, Stott DJ, Soria JM, de Maat MPM, Almasy L, Brody LC, Auer PL, Mitchell BD, Ben-Shlomo Y, Fornage M, Hayward C, Mathias RA, Kilpeläinen TO, Lange LA, Cox SR, März W, Morange PE, Rotter JI, Mook-Kanamori DO, Wilson JF, van der Harst P, Jukema JW, Ikram MA, Blangero J, Kooperberg C, Desch KC, Johnson AD, Sabater-Lleal M, Lowenstein CJ, Smith NL, Morrison AC.

Blood. 2024 Feb 6:blood.2023021452. doi: 10.1182/blood.2023021452. Online ahead of print.

PMID: 38320121

 

Unique immune profiles in collaborative cross mice linked to survival and viral clearance upon infection. 

Graham JB, Swarts JL, Leist SR, Schäfer A, Bell TA, Hock P, Farrington J, Shaw GD, Ferris MT, Pardo-Manuel de Villena F, Baric RS, Lund JM.

iScience. 2024 Feb 2;27(3):109103. doi: 10.1016/j.isci.2024.109103. eCollection 2024 Mar 15.

PMID: 38361611 Free PMC article.

 

Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive disorder. 

Song J, Jonsson L, Lu Y, Bergen SE, Karlsson R, Smedler E, Gordon-Smith K, Jones I, Jones L, Craddock N, Sullivan PF, Lichtenstein P, Di Florio A, Landén M.

Mol Psychiatry. 2024 Feb 14. doi: 10.1038/s41380-024-02448-1. Online ahead of print.

PMID: 38355785

 

Generation of Human Isogenic Induced Pluripotent Stem Cell Lines with CRISPR Prime Editing. 

Bonnycastle LL, Swift AJ, Mansell EC, Lee A, Winnicki E, Li ES, Robertson CC, Parsons VA, Huynh T, Krilow C, Mohlke KL, Erdos MR, Narisu N, Collins FS.

CRISPR J. 2024 Feb;7(1):53-67. doi: 10.1089/crispr.2023.0066.

PMID: 38353623

 

Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities. 

Jiang YZ, Ma D, Jin X, Xiao Y, Yu Y, Shi J, Zhou YF, Fu T, Lin CJ, Dai LJ, Liu CL, Zhao S, Su GH, Hou W, Liu Y, Chen Q, Yang J, Zhang N, Zhang WJ, Liu W, Ge W, Yang WT, You C, Gu Y, Kaklamani V, Bertucci F, Verschraegen C, Daemen A, Shah NM, Wang T, Guo T, Shi L, Perou CM, Zheng Y, Huang W, Shao ZM.

Nat Cancer. 2024 Feb 12. doi: 10.1038/s43018-024-00725-0. Online ahead of print.

PMID: 38347143

 

Reflections on ‘common’ genetic medical history questions: Time to examine the what, why, and how. 

Waltz M, Foreman AKM, Canter C, Cadigan RJ, O’Daniel JM.

Patient Educ Couns. 2024 Feb 5;122:108190. doi: 10.1016/j.pec.2024.108190. Online ahead of print.

PMID: 38340501

 

Public participation in human genome editing research governance: what do scientists think? 

Waltz M, Flatt MA, Juengst ET, Conley JM, Cadigan RJ.

J Community Genet. 2024 Feb 14. doi: 10.1007/s12687-024-00701-2. Online ahead of print.

PMID: 38353891

 

Emerging evidence linking stress and glucocorticoid signaling with cancer phenotypes. 

Zannas AS.

J Transl Med. 2024 Feb 12;22(1):147. doi: 10.1186/s12967-024-04962-w.

PMID: 38347561 Free PMC article. No abstract available.

 

A comprehensive patient-specific prediction model for temporomandibular joint osteoarthritis progression. 

Al Turkestani N, Li T, Bianchi J, Gurgel M, Prieto J, Shah H, Benavides E, Soki F, Mishina Y, Fontana M, Rao A, Zhu H, Cevidanes L.

Proc Natl Acad Sci U S A. 2024 Feb 20;121(8):e2306132121. doi: 10.1073/pnas.2306132121. Epub 2024 Feb 12.

PMID: 38346188

 

Model-Based Prediction of Irinotecan-Induced Grade 4 Neutropenia in Cancer Patients: Influence of Incorporating Germline Genetic Factors in the Model. 

Karas S, Mathijssen RHJ, van Schaik RHN, Forrest A, Wiltshire T, Bies RR, Innocenti F.

Clin Pharmacol Ther. 2024 Feb 12. doi: 10.1002/cpt.3190. Online ahead of print.

PMID: 38344867