Juan Song

Nancy Allbritton

Assistant Professor

Department of Pharmacology

Primary Member UNC Neuroscience Center

Ph.D., Neuroscience
University of California, Berkeley

Biosketch [.pdf]

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Research Interests

  • Adult neurogenesis function and regulation

Research Synopsis

Adult neurogenesis occurs in a unique microenvironment (niche) and recapitulates the complete neural developmental process in a mature central nervous system. Our primary research interests are: 1) To identify the circuit mechanisms that regulate neural circuit organization and function at distinct stages of adult neurogenesis, including activation and fate choice of quiescent neural stem cells, survival of proliferating neural progenitors, and synaptic integration of newborn neurons; 2) To understand how circuit-level information-processing properties are remodeled by the integration of new neurons into existing circuits and how disregulation of this process may contribute to various neurological and mental disorders. Our long-range goals are to translate general principles governing neural network function into directions relevant for understanding neuropsychiatric diseases, such as schizophrenia and autism, and neuronal replacement therapy for brain injuries, such as stroke and Alzheimer’s disease. We are addressing these questions using a combination of innovative and multifaceted approaches, including in vivo optogenetics and electrophysiology, patch-clamp recordings, clonal analysis for lineage tracing, high-resolution confocal microscopy, and sophisticated mouse genetic models. 

The Song lab is currently recruiting motivated postdoctoral fellows, graduate students, research associates, and undergraduates.

Publications

pubmed

Click above for PubMed publications.

 

  • Song J, Sun J, Moss J, Wen Z, Sun G, Hsu D, Zhong C, Davoudi H, Christian K, Toni N, Ming GL, Song H (2013). Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus. Nature Neuroscience 16(12):1728-30, PMID:24212671.  Abstract
  • Zhou M, Li W, Huang S, Song J, Kim JY, Tian X, Kang E, Liu C, Balaji J, Zhou Y, Parivash SN, Zhou Y, Ehninger D, He L, Song H, Ming GL, Silva AJ (2013) mTOR inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown specifically in adult-born dentate granule neurons. Neuron 77(4):647-54. Abstract
  • Song J, Zhong C, Bonaguidi MA, Sun G, Hsu D, Gu Y, Meletis K, Huang J, Ge S, Enikolopov G, Deisseroth K, Luscher B, Christian K, Ming GL, Song H (2012). Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. Nature 489: 150-154 (Featured in Cell Stem Cell, Nat Rev Neurosci, BioEssays, F1000 must read). Abstract
  • Song J, Christian K, Ming GL, Song H (2012). Life or death: developing cortical interneurons make their own decision. EMBO J 31(23):4373-4. Abstract
  • Song J*, Christian K, Ming GL, Song H (2012). Modification of hippocampal circuitry by adult neurogenesis. Dev Neurbiol. 72(7):1032-43 (*: corresponding author). Abstract
  • Bonaguidi MA#, Song J#, Ming GL, Song H (2012). A unifying hypothesis on mammalian neural stem cell properties in the adult hippocampus. Curr Opin Neurobiol.22(5):754-61 (#: co-first author, equal contribution). Abstract
  • Song J*, Hu J and Tanouye M (2007). Seizure suppression by top1 mutations in Drosophila. J. Neuroscience 27 (11): 2927-2937. (*: corresponding author). Abstract

Lab Members

The Song lab is currently recruiting motivated postdoctoral fellows, graduate students, research associates, and undergraduates.

Contact Information

Office Location:
4073 Genetic Medicine Bldg.

Mailing Address:
CB # 7365
UNC-CH Dept. of Pharmacology
Chapel Hill, NC 27599-7365

Office Phone: 919-843-9363
Fax: 919-966-5640
juansong[at]email.unc.edu

 

 

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