Spring Courses

BIOC/CBIO 644  CELL BIOLOY II: CELL STRUCTURE, FUNCTION, AND GROWTH CONTROL II (3 Credits) Prerequisites, undergraduate cell biology or biochemistry or permission of the instructor.  Comprehensive introduction to cell structure, function, and transformation.  Spring. Cox.  2:20-2:50 pm, MWF, 124 Taylor Hall.

BIOC 661  ADVANCED TOPICS IN IMAGING  (2 credits).  A treatment of optical imaging, including fluorescence and confocal techniques. Discusses of electron imaging, including trasmission electron  microscopy (TEM), scanning electron microscopy (SEM), and image interpretation. Brief descriptions of the basic principles and applications of mechanical imaging using scanning probe microscopy (SPM). Spring. Costello (course director), Erie, Jacobson, Salmon, Superfine.  TTH 2-3:15pm in Taylor, Lab F in Taylor.

BIOC 662  MACROMOLECULAR INTERACTIONS (Chemistry 235) (1 credit). Prerequisites, Biochemistry 650-652 or permission of course director. Theory and practice of biophysical methods used in the study of interactions between macromolecules and their ligands including surface plasmon resonance, analytical ultracentrifugation, and calorimetry. Spring. Tripathy (course director). MWF 11:00 – 11:50 am, 305 MEJ.

BIOC 663A  MACROMOLECULAR NMR THEORY (Chemistry 234) (1 credit). Prerequisite, Biochemistry 653 or permission of the course director. This is the lecture component of a combined lecture/laboratory course that provides a practical introduction to the use of macromolecular NMR spectroscopy. The lecture may be taken independently of the lab (BIOC 152L). Spring. Campbell (course director), Pielak, Terhosst.  11:00 – 11:50 am, 305 MEJ.

BIOC 663B  MACROMOLECULAR NMR PRACTICE (Chemistry 234) (1 credit). Prerequisite, Biochemistry 653 or permission of course director. Lab section for BIOC 663A. Spring. Campbell (course director), Pielak, Terhosst. .

BIOC 664  MACROMOLECULAR SPECTROSCOPY (1 credit). Prerequisites, Chemistry 130 and two semesters of physical chemistry or permission of the instructor. Principles of UV, IR, Raman, fluorescence, and spin resonance spectroscopies; applications to the study of macromolecules and membranes. Spring. Lentz.  11:00 – 11:50 am, 305 MEJ.

BIOC 666  X-RAY CRYSTALLOGRAPHY OF MACROMOLECULES (Chemistry 233) (1 credit). Prerequisite, Biochemistry 144 or permission of course director. Principles of protein crystallography; characterization of crystals; theory of diffraction; phasing of macromolecular crystals and structure refinement. Spring. Ke (course director). 966-2244. MWF 9-9:50am. 305 MEJ.

BIOC 670  BIOMOLECULAR INFORMATICS (1 credit). Prerequisites, Biochemistry 144-147 or permission of instructor. A combined workshop/distance learning course introducing the methods and principles of biological data management as this relates to macromolecular sequence analysis. Spring. Kuhlman (course director). TTH 9:30-11 am, 305 MEJ.

BIOC 673  PROTEOMICS, PROTEIN IDENTIFICATION AND CHARACTERIZATION BY MASS SPECTROMETRY (1 credit).  Prerequisite, BIOC 144-147 or one semester of Physical Chemistry or permission of instructor.  A lecture module that introduces students to the basics of mass spectrometry as applied to protein science.  Spring.  Chen (course director). 843-5310. MWF 11:00 – 11:50 am, 305 MEJ.

BIOC 678  INTRODUCTION TO ELECTROPHYSIOLOGY (1 credit).  The first sectin of Physiology 703. Introduction to electrical phenomena, resting membrane potentials; the Nernst equation, single channel behavior, ion channel populations, the cardiac action potential, ion channel protein structure, and synaptic transmission.  Spring.  Sealock (course director). 966-1272. 

BIOC 700  CURRENT TOPICS IN RNA STRUCTURE, FUNCTION, AND TECHNOLOGY (2 credits). Prerequisite, Permission of the Instructor.  Critical reading and discussion of current literature r elated to the study of RNA structure, RNA-protein interactions, novel RNA functions, RNA as a therapeutic target/agent, and methods for the study of RNA.  Spring.  Fried (course director), Thapar.  TBA.

BIOC 701  CRITICAL ANALYSIS IN BIOCHEMISTRY (2 credit). Critical analysis of current research in conjunction with biochemistry faculty and departmental seminar series. Students select and present research papers and lead discussions. Course provides an opportunity to become familiar with tdepartmental research as well as state-of-the-art and standard laboratory techniques. Spring. Fried (course director). TBA.

POSSIBLE ELECTIVE COURSES TO TAKE IN OTHER DEPARTMENTS
(this is not an exhaustive list of available elective courses)

BIOL 625 (270) SEMINAR IN GENETICS (2). Prerequisite, permission of instructor. Current and significant problems in genetics. May be repeated for credit.  Spring.  Searles.  TBA

BIOL 632 (179) ADVANCE MOLECULAR BIOLOGY II (3). Prerequisites for undergraduates, at least one undergraduate course in both biochemistry and genetics. RNA structure, function, and processing in biological systems including transcription, gene regulation, translation, and oncogenes. Three lecture hours a week.  Spring.  Marzluff, Salmon.  TBA

BIOL 639 (272) SEMINAR IN PLANT CELL BIOLOGY (2). Prerequisite, permission of the instructor. May be repeated for credit. Current and significant problems in plant molecular and cell biology are discussed in a seminar format.  Spring.  A. Jones.  TBA

BIOL 649 (254) SEMINAR IN CELL BIOLOGY (2). Prerequisite, BIOL 205 or permission of the instructor. May be repeated for credit.  Spring.  Salmon, Bloom..  TBA

BIOL 659 (258) SEMINAR IN EVOLUTIONARY BIOLOGY (2). Prerequisite, BIOL 471 or permission of instructor. Advanced topics in evolutionary biology.  Spring.  Pfennig, Burch.  TBA

BIOL 857 (259) SEMINAR IN COMPARATIVE ANIMAL BEHAVIOR (2). (also NBIO 857) Prerequisite, permission of the instructor. May be repeated for credit. Fall or spring. Sockman. TBA.

BMME 405 (102) BIOMECHANICS (3 credits). Prerequisites: Physics 26, MATH 83 or equivalent, and permission of the instructor.  Fundamental principles of solid and fluid mechanics applied to biological systems. Human gait analysis, joint replacement, testing techniques for biological structures and viscoelastic models are presented.  Papers from the current biomechanics literature will be discussed.  Dr. Paul Weinhold. (paul_weinhold@med.unc.edu) Tuesday/Thursday 3:30-4:45 pm

BMME 410 SYSTEMS AND SIGNALS (3 credits). Prerequisite: Physics 101 and permission of the instructor. Analysis of linear systems by transform methods to networks, including stability analysis. Survey of numerical methods for network solutions.  Dr. Stephen Quint     (quint@bme.unc.edu)Tuesday/Thursday 9:30-10:45am

BMME 430 (121) DIGITAL SIGNAL PROCESSING I (3 credits). Prerequisite: Computer Science 14 or equivalent. This is an introduction to methods of automatic computation of special relevance to biomedical problems.  Sampling theory, analog-to-digital conversion and digital filtering, will be explored in depth. Dr. Carol Lucas     (clucas@bme.unc.edu)Tuesday/Thursday 8:00-9:15 am  

BMME 465 (111) BIOMEDICAL INSTRUMENTATION I (4 credits). Topics include basic electronic circuit design, analysis of medical instrumentation circuits, physiologic transducers (pressure, flow, bioelectric, temperate and displacement). This course includes a laboratory where the students build biomedical devices. Dr. Henry Hsiao  (hsiao@med.unc.edu) Tuesday/Thursday 2:20-3:35pm

BMME 530 (154) MICROELECTRODE TECHNIQUES (4 credits). Prerequisites: Physics 101 and Biology 11 or equivalent. Methods for measurement of cellular transmembrane voltages with microelectrodes are introduced. Basic and technical aspects of the measurements are described. Students fabricate microelectrodes and measure action potentials in living cells. Dr. Stephen Knisley  (sknisley@bme.unc.edu) Wednesday 2:45-5:00 pm

BMME 750 (232) DIGITAL CONTROL THEORY (3 credits). Prerequisite: BMME 450 or equivalent. Discrete time system performance and stability are represented in the time and frequency domains. Series compensation and state variable design techniques are studied. Student projects include discrete time control designs, simulations and implementation using laboratory devices. Dr. Stephen Quint (quint@bme.unc.edu). MW 2:20-3:35on

BMME 780 (220) REAL-TIME COMPUTER APPLICATIONS II (3). Prerequisites, BMME480, 465. Problems of interfacing computers with biomedical and systems are studied. Students collaborate to develop a new biomedical instrument. Projects have included process control, data acquisition, disk systems interfaces, and DMW interfaces between interconnected computers. Goldberg.

BMME 795 (282) INFORMATION PROCESSING IN THE SOMATOSENSORY NERVOUS SYSTEM: BRAIN IMAGING AND DATA ANALYSIS METHODS (3 credits). Prerequisite: BMME 589 or permission of instructor. The central purpose of this course is to provide a comprehensive but concise introduction to state-of-the-art experimental methodologies that can be used to characterize (a) the aggregate behavior of living neural networks; and (b) the changes in that behavior that occur as a function of stimulus properties, pharmacological manipulations, and other factors that dynamically modify the functional status of the network. Dr. Mark Tommerdahl (tommerda@med.unc.edu) MW 11:00-12:30pm

BMME 840 (290) REHABILITATION ENGINEERING DESIGN (4 credits). Prerequisites: BMME 465 or permission of instructor. Students will design an assistive technology device to help individuals with disabilities to become more independent. Project will be used in community when it is completed. Dr. Richard Goldberg (rlg@bme.unc.edu) W 1:15-2:30pm, F (lab) 1:00-4:00pm

BMME 860 (230) NUMERIC METHOD (3 credits). Prerequisites: MATH 34. Theory and applications of numerical differential and integral equations, multiparameter minimization, Monte Carlo methods. Oriented towards computer solutions of engineering problems. Dr. Oleg Favorov (favorov@bme.unc.edu) MW 1:00-2:15 pm

BMME 505 (102) BIOMECHANICS (3 credits). Prerequisites: Physics 26, MATH 83 or equivalent, and permission of the instructor.  Fundamental principles of solid and fluid mechanics applied to biological systems. Human gait analysis, joint replacement, testing techniques for biological structures and viscoelastic models are presented.  Papers from the current biomechanics literature will be discussed.  Dr. M.T. Gross M 6:00pm-9:00pm

BMME 465 (111) BIOMEDICAL INSTRUMENTATION I (4 credits). Topics include basic electronic circuit design, analysis of medical instrumentation circuits, physiologic transducers (pressure, flow, bioelectric, temperate and displacement). This course includes a laboratory where the students build biomedical devices. Dr. Henry Hsiao  (hsiao@med.unc.edu) Tuesday/Thursday 2:00-3:15pm

BMME 532 (154) MICROELECTRODE TECHNIQUES (4 credits). Prerequisites: Physics 101 and Biology 11 or equivalent. Methods for measurement of cellular transmembrane voltages with microelectrodes are introduced. Basic and technical aspects of the measurements are described. Students fabricate microelectrodes and measure action potentials in living cells. Dr. Stephen Knisley     (sknisley@bme.unc.edu) Wednesday 2:45-5:00 pm

581 [220] MICROCONTROLLER APPLICATIONS II (3). Prerequisites, BMME 480, 465. Problems of interfacing computers with biomedical and systems are studied. Students collaborate to develop a new biomedical instrument. Projects have included process control, data acquisition, disk systems interfaces, and DMW interfaces between interconnected computers. Dr. RIchard Goldberg (rlg@bme.unc.edu) TR 11:00-12:15 pm

740 [212] ADVANCED BIOMATERIALS (MTSC 740) (3). Prerequisite, BMME 510 or permission of the instructor. Medical or dental implants or explants are highlighted from textbooks, scientific literature, and personal accounts. Dr. Albert  Banes, Dr. Roger Narayan (albert_banes@med.unc.edu, roger_narayan@unc.edu) MWF 10:00-10:50am

BMME 750 (232) DIGITAL CONTROL THEORY (3 credits). Prerequisite: BMME 450 or equivalent. Discrete time system performance and stability are represented in the time and frequency domains. Series compensation and state variable design techniques are studied. Student projects include discrete time control designs, simulations and implementation using laboratory devices. Dr. Stephen Quint (quint@med.unc.edu). MW 2:20-3:35pm

770 [251] PHYSIOLOGY AND METHODS IN GENOMICS (5). Prerequisites, BMME 570 or undergraduate organic chemistry or biochemistry and undergraduate biology or with permission of instructor. Lectures in physiology systems and lab techniques covering various functional genomic methods including DNA sequencing, gene arrays, proteomics, confocal microscopy, and imaging modalities. Dr. Albert Banes (albert_banes@med.unc.edu) MWF 12:30-2:00pm

*790 [281] SYSTEMS PHYSIOLOGY FOR BIOMEDICAL ENGINEERS (3). Prerequisite, BMME 589. This is the second semester of the two-semester series intended to provide graduate students with an introduction to systems and organ physiology. Dr. Mark Tommerdahl (tommerda@med.unc.edu) MWF 11:00-11:50am F 2:00-2:50pm

BMME 795 (282) INFORMATION PROCESSING IN THE SOMATOSENSORY NERVOUS SYSTEM: BRAIN IMAGING AND DATA ANALYSIS METHODS (3 credits). Prerequisite: BMME 589 or permission of instructor. The central purpose of this course is to provide a comprehensive but concise introduction to state-of-the-art experimental methodologies that can be used to characterize (a) the aggregate behavior of living neural networks; and (b) the changes in that behavior that occur as a function of stimulus properties, pharmacological manipulations, and other factors that dynamically modify the functional status of the network. Dr. Mark Tommerdahl (tommerda@med.unc.edu) MW 9:00-9:50am

BMME 840 (290) REHABILITATION ENGINEERING DESIGN (4 credits). Prerequisites: BMME 465 or permission of instructor. Students will design an assistive technology device to help individuals with disabilities to become more independent. Project will be used in community when it is completed. Dr. Richard Goldberg (rlg@bme.unc.edu) W 1:15-2:30pm, F (lab) 1:00-4:00pm

BMME 860 (230) NUMERIC METHOD (3 credits). Prerequisites: MATH 34. Theory and applications of numerical differential and integral equations, multiparameter minimization, Monte Carlo methods. Oriented towards computer solutions of engineering problems. Dr. Oleg Favorov (favorov@bme.unc.edu) MW 1:00-2:15 pm

CBIO 423  Embryology and Teratology (3 Credits) Prerequisites, permission of the instructor.  Topics of current interest relative to the genesis of environmentally-caused and genetically-based birth defects will be emphasized.  Additionally, fundamentals of mammalian embryogenesis, including basic aspects of mammalian molecular development will be taught.  Spring. Sulik, Hunter, Rogers.9-12 am, T, 6201 MBRB Taylor Hall.

CBIO 644  CELL BIOLOY II: CELL STRUCTURE, FUNCTION, AND GROWTH CONTROL II (3 Credits) Prerequisites, undergraduate cell biology or biochemistry or permission of the instructor.  Comprehensive introduction to cell structure, function, and transformation.  Spring. Cox.  2:20-2:50 pm, MWF, 124 Taylor Hall.

CBIO 892B  Contemporary Approaches to Solving Basic Problems in Cell and Developmental Biology (3 Credits) Prerequisites, permission of the instructor.  Analysis of grant proposals dealing with advanced topics in modern cell biology and/or developmental biology.  Spring. Dr. Vytas Bankaitis (vytas@med.unc.edu). TBA

CBIO 894  Advanced Cell Biology II  (4 Credits) Prerequisites, permission of the instructor.  Literature based discussion course on the application of modern approaches from multiple disciplines to problems in Cell Biology. Spring. Dr. Mohanish Deshmukh (mohanish@med.unc.edu). 3-5 pm, T, Th, 6201 MBRB.

GNET 622 (113) - PRINCIPLES OF GENETIC ANALYSIS IN HUMANS & MICE (4 credits). Prerequisite, GNET 621 Principles of Genetic Analysis 1. Principles of genetic analysis in higher eukaryotes; genomics.  This course emphasizes genetic processes that are unique to mammals and that are relevant to human health.  The course will move beyond the paradigm centered on characterization of gene function based on null alleles, to how different types of variation at multiple loci affects genetic traits.  Topics include mouse as a model genetic system, human Mendelian disease conditions, analysis of complex multi-gene traits, epigenetics, and population genetics. Spring. 12:30-1:45 pm, Tues/Thurs. Farber, Pardo-Manuel de Villena. Probable meeting place-Taylor Hall 124.

GNET 632 (111) - ADVANCED MOLECULAR BIOLOGY II  (3 credits). Prerequisites, at least one undergraduate course in both biochemistry and genetics and permission of the instructor.  The purpose of this course is to provide historical, basic and current information about the flow and regulation of genetic information from DNA to RNA in a variety of biological systems.  Topics include  mechanisms of gene regulation, transcription, histone modifications, protein translation and transport, and RNA structure, function, processing, and transport. Spring. Baldwin, Strahl, Marzluff  9:00 – 9:50 am, MWF, Location TBA

GNET 641 - INTRO TO BIOINFORMATICS (4 Credits). Permission of Instructor is required to enroll.  Genomics and Bioinformatics.  This course provides an introduction to basic genome informatics, including; genome databases, sequence analysis, gene expression analysis, protein structural analysis, and managing the scientific literature.  Class will most often consist of a one hour lecture followed by 2 hours of “hands-on” time in the computer lab. Spring. 1:00-4:00 pm, MWF.  Kelkar, et al.  Biogen Idec Classroom 307 Health Sciences Library.

GNET 632 [109] ADVANCED MOLECULAR BIOLOGY II (GNET, BIOC, PHCO, BIOL 632)(3). Prerequisites for undergraduates, at least one undergraduate course in both biochemistry and genetics and permission of the instructor. RNA structure, function, and processing in biological systems including transcription, gene regulation, translation, protein and RNA transport. Spring. Marzluff, Baldwin, Strahl, staff.

GNET 640 [140] MICROBIAL PATHOGENESIS II (3). Prerequisites, a fundamental understanding of molecular virology and immunology and permission of instructor. Molecular pathogenesis, with a primary focus on viral pathogens.  Additional topics include vaccines and genetics of host-pathogen interactions. Spring.

GNET 644 [118] CELL STRUCTURE, FUNCTION AND GROWTH CONTROL II (CBIO, BIOC, PHCO 644) (3). Prerequisite, undergraduate cell biology or biochemistry or permission of the instructor. Comprehensive introduction to cell structure, function, and transformation. Spring. Cox.

NBIO 723A (223A) CELLULAR AND MOLECULAR NEUROBIOLOGY:  POSTSYNAPTIC MECHANISMS-INTRACELLULAR SIGNALING (2 credits) Prerequisite, permission of the instructor. Explores biochemical signal transduction events following activation of neurotransmitter receptors including G-protein coupling, desensitization, signaling specificity, downstream effectors, calcium signaling and tryosine kinases. Course meets for five weeks with six lecture hours per week. Spring. Stuart

NBIO 723B (223B) CELLULAR AND MOLECULAR NEUROBIOLOGY:  PRESYNAPTIC MECHANISMS (2 credits) Prerequisite, permission of instructor. Explores mechanisms regulating the release of neurotransmitters from nerve terminals including quantal release, vesicle and terminal membrane proteins, neurotransmitter transporters, and plasticity of synaptic transmission. Course meets for five weeks with six lecture hours per week. Spring. Stuart and faculty.

NBIO 723C (223C) CELLULAR AND MOLECULAR NEUROBIOLOGY:  ANATOMY AND FUNCTION OF SENSORY SYSTEMS (2 credits) Sensory pathways of the olfactory, visual, auditory and somatosensory systems are explored, and the mechanisms of sensory information processing and analyses of fMRI are discussed. Includes sessions on human brain neuroanatomy. Spring. Stuart and faculty. 

NBIO 850 COMMUNICATING SCIENCE:  Prerequisite, permission of the instructor.  This class employs faculty coaching and peer critiquing to develop students' skills in speaking and writing about science with ease, clarity, and precision. The class aims to build self-confidence and the ability to take criticism without defensiveness. It meets once a week for 1.25 hours for both semesters. Students take this course for two years; second-year students are paired with first-year students as mentors, as rehearsal partners, and as editing partners for written assignments.

PATH 464 (164) LIGHT MICROSCOPY (3 credits). Prerequisite, permission of the instructor. Course focuses on practical fundamentals of light microscopy including optics, contrast mechanisms, fluorescence, laser scanning confocal microscopy, photography, and digital imaging. Three lecture hours a week. C. Robert Bagnell, Jr., PhD (966-2413) bagnell@med.unc.edu. Tues/Thurs 11:00am-12:30pm. http://www.med.unc.edu/microscopy/, B05 Brinkhous-Bullitt. Building

PATH 715 SYSTEMIC PATHOLOGY (3 credits). A graduate-level laboratory course on systemic pathology, emphasizing diseases of major organ systems.  The histologic and tissue presentation of major forms of disease will be presented in conjunction with normal cell and tissue histology. William B. Coleman, PhD (966-2699) wcolemn@med.unc.edu. Lectures on Mon/Wed/Fri at 11:00-11:50am, Rm/Bldg TBA

PATH 716L SYSTEMIC PATHOLOGY: LAB (2 credits). Concurrent enrollment in Path 715 or prior completion of Path 715 (optional for non-majors). A graduate-level laboratory course on systemic pathology, emphasizing disease of major organ systems.  Wednesdays at 1:00-3:30pm, Rm/Bldg TBA.

PATH 725 (225) CANCER PATHOLOGY (3 credits). Permission of the course director required. This course examines pathobiological features of cancer. An interdisciplinary approach draws from epidemiology, genetics, molecular biology, and clinical medicine to investigate cancer etiology, pathogenesis, prevention, and treatment. Three lecture hours a week. William K. Kaufmann, PhD (966-8209) mailto:wkarik@med.unc.edu. Tues/Thur 10:00-11:30am, Rm/Bldg TBA.

PATH 792 (292) SEMINAR IN CARCINOGENESIS (Toxicology 792) (2 credits). Prerequisite, permission of the instructor. Survey of classical and current literature on selected critical issues in carcinogenesis. Students discuss experimental methods and observations as well as theories and generalizations. Two seminar hours a week.  William B. Coleman, PhD (966-2699) wbcolemn@med.unc.edu. Thurs 1:00-3:00pm, Rm/Bldg. TBA.

PHCO 702 (202)/TOXC 702 (202) PRINCIPLES OF PHARMACOLOGY AND TOXICOLOGY (3 credits). Permission of the instructor required.  Introduces students to the major areas of pharmacology and toxicology and serves as a basis for more advanced courses.  Three lecture hours a week.  Spring.  Johnson, 9:00-9:50, MWF.

PHCO 728 (221E) ALCOHOL AND SUBSTANCE ABUSE. (2 credits)  Permission of the instructor required.  A lecture/discussion course on the biological bases of alcohol and substance abuse.  Spring. Alternate years. L. Morrow.

PHCO 736 (221J) PROTEIN KINASES AS TARGETS FOR NOVEL PHARMACOLOGICAL INHIBITORS. (2 credits) The purpose of this course is to evaluate the use of small molecule inhibitors of protein kinases from a structural and signal transduction.  Topics include:  target identification and validation, drug discovery, the process of government approval for clinical trials, design of clinical trials, and new genetic-based technologies to foster drug development.  Spring, alternate years. Graves/G. Johnson.

PHYI 706 COMMUNICATING SCIENTIFIC RESULTS  (1) Permission required for non-majors. Practice in oral and written communication evaluated by peers and faculty. Includes delivery of coached presentations on topics in physiology and preparation of writing assignments typically encountered in scientific life. Time TBA . Stuart.

PHYI 710  MEDICAL NEUROBIOLOGY (1- 3).  Prequisite, permission of the course director.  A special section for graduate students of the neurobiology course for medical students.  Structural and functional organization is analysed at the level of the cell membrane, the neuron, and integrated neuronal systems. Rustioni, faculty.

PHYI 720  HUMAN PHYSIOLOGY (1 - 3).  Prequisite, permission of the course director.  A special section for graduate students of the meical physiology course for medical students. The course provides a general consideration of cell function and of systemic physiology  

PHYI 723A CELLULAR & MOLECULAR NEUROBIOLOGY: PRESYNAPTIC MECHANISMS (2) (Neurobiology 723A).Permission of instructor required. The mechanisms regulating the release of neurotransmitters from nerve terminals are explored including quantal release, vesicle and terminal membrane proteins, neurotransmitter transporters, and plasticity of synaptic transmission. 10 - 12 MWF, Manis and faculty.  

PHYI 723B CELLULAR & MOLECULAR NEUROBIOLOGY: POSTSYNAPTIC MECHANISMS-INTRACELLULAR SIGNALING (2) (Neurobiology 723B) Permission of instructor required. The biochemical signal transduction events following activation of neurotransmitter receptors are explored including G-protein coupling, desensitization, signaling specificity, downstream effectors, calcium signaling and tyrosine kinases. 10 - 12 MWF.  Spring. Maness and faculty.

PHYI 832  RESPIRATORY PHYSIOLOGY: DEFENSE MECHANISMS OF THE AIRWAYS (1.5) Prerequisites, PHYI 703 or equivalent .  Focus on the integrated defense mechanisms that protect the airways and lungs from inhaled allergens, irritants, particulates, and pathogens.  Specific topics include transepithelial ion transport, mucociliary clearance and innate immune responses.  Meets 3 times/week for the 2nd half of the semester.  Time TBA.  Davis, Randell, Tarran.