April 4, 2022
Platelets are critical in hemostasis and a major contributor to arterial thrombosis (AT). (Pre)clinical studies suggest platelets also contribute to venous thrombosis (VT), but the mechanisms are largely unknown. Jean Marie Mwiza, a graduate student in the Pathology department jointly supervised by Drs. Alisa Wolberg and Wolfgang Bergmeier, recently spear-headed an international team of investigators …
April 4, 2022
Platelet homeostasis, i.e. a stable platelet count in the circulation, is dependent on a tight regulation of both platelet production and clearance. Dr. Robert Lee, in collaboration with members of the Bergmeier lab, the Flick lab, and international collaborators, recently published their studies on the effect of uninhibited signaling by the small GTPase Rap1 on …
March 17, 2022
Dr. Nigel Key co-authored a manuscript describing the pivotal multi-center Phase 3 clinical trial of adeno-associated virus 5 (AAV5)- based gene therapy for severe hemophilia A that was published in the New England Journal of Medicine on March 17, 2022. The trial sponsor was Biomarin Pharmaceutical. Of 134 participants with severe hemophilia who were enrolled, …
March 3, 2022
Stephan Moll, MD gave a presentation at the NFL Combine Scientific Meeting on March 2, 2022 on “Athletes and Venous Thromboembolism: Intermittent Anticoagulation Management Strategy – Update” Following his initial Feb 2020 in-person presentation to the NFL team’s Sports Medicine physicians at the annual NFL Physicians’ Society meeting at the NFL Combine in Indianapolis, Dr. …
March 2, 2022
Brandi Reeves, MD, Assistant Professor of Medicine and Rafal Pawlinski, PhD, Lenvil Lee Rothrock Distinguished Professor of Medicine, were awarded a $50,000 TraCS Translational Team Science pilot grant to study Hypoxia Inducible Factors in Myeloproliferative Neoplasm-Associated Thrombosis. NC TraCS Award Announcements
February 28, 2022
Nigel Key, MB, ChB, FRCP has been awarded a 5-year, $2.2 million T32 grant from the National Heart, Lung, and Blood Institute (NHLBI). Now closely aligned with the benign hematology research areas of focus in the Blood Research Center (hemostasis, thrombosis and sickle cell disease), the program will continue to recruit MD and PhD trainees for …
February 21, 2022
UNC Blood Research Center member Stephan Moll, MD is a coauthor on a paper published in the Journal of Thrombosis and Haemostasis. The article, Risk of recurrence in women with venous thromboembolism related to estrogen-containing contraceptives: Systematic review and meta-analysis” provides data showing that women with DVT or PE associated with estrogen-containing contraceptives, the risk …
February 17, 2022
Steven Grover, PhD, a postdoctoral fellow in the laboratory of Nigel Mackman, has been selected to receive a Fellow to Faculty Scholar Award from the American Society of Hematology. The prestigious ASH Scholar Awards provide financial support to fellows and junior faculty with dedicated careers in hematology research, as they transition from training programs to …
February 16, 2022
UNC BRC Faculty members Dr. Erica Sparkenbaugh, Dr. Rafal Pawlinski, and Dr. Nigel Key are highlighted in a Photo Essay called “Magnificent Magnification” in the UNC Research newsletter, Endeavors. The image is a scanning electron micrograph of a blood clot from a patient with sickle cell disease. https://endeavors.unc.edu/magnificent-magnification/
February 16, 2022
Brandi Reeves, MD, Assistant Professor of Medicine, was awarded a 2-year Hemostasis & Thrombosis Research Society Mentored Research Award to evaluate the role of hypoxia-inducible factors (HIF) in myeloproliferative neoplasm (MPN)-associated thrombosis. Rafal Pawlinski, Phd, and Nigel Key, MBBS CHB FRCP, will serve as mentors for the project. Thrombosis is the leading cause of mortality …
February 14, 2022
Published works from Jennifer Newman, MSPT; UNC Hemophilia Treatment Center Physical therapy within US HTCs: Amulticentre survey of utilization, practice patterns and pain management approaches. Read publication in Haemophilia
January 13, 2022
Erica Sparkenbaugh, Research Assistant Professor in the Blood Research Center and Division of Hematology will give a talk entitled “The Role of Thrombin and PAR-1 in Microvascular Stasis in Sickle Cell Disease” to the North American Vascular Biology Organization in an Online Symposium on Thrombosis in Vascular Occlusive Disorders. More information: Navbo symposium Register online: …