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View BRC January 2026 Newsletter January 2026 Newsletter

Key Lab publishes study describing rapid and sensitive assay for hyperfibrinolysis in plasma. In collaboration with colleagues in the UK who first described a form of severe post-partum hemorrhage (PPH) characterized by marked hyperfibrinolysis, a novel rapid assay for fibrinolytic activation in plasma developed in the lab (the Fibrinolytic Activation Screening Test or ‘FAST’...

Robert Lee, PhD and Wolfgang Bergmeier, PhD, were part of a team studying the contribution of platelets to mast cell activation in sepsis, published in the Journal Nature Communications.     https://pubmed.ncbi.nlm.nih.gov/41339353/    

Aleksei Martianov, postdoc in the Bergmeier lab, presented his work as an oral presentation at ASH, his presentation was featured in “Best of ASH”, and he received the inaugural ASH Richard T. Silver, MD Abstract Achievement Award for Myeloproliferative Neoplasms. In addition, Aleksei was awarded the Staff Excellence Award for...

YJ Choi, an MD/PhD trainee in Wolberg laboratory, received a NOA for her AHA proposal entitled, “Define and Target Genetic Regulators of Fibrinogen Synthesis to Reduce Thrombosis”

Nigel Key Co-Authors Pivotal Hemophilia Gene Therapy Study in NEJM   Nigel Key was a contributing author on the final analysis of the HOPE-B study results that were published online in in the New England Journal of Medicine on December 7, 2025 coincident with presentation of the data at the...

Nigel Mackman featured in: 29 Carolina faculty named ‘highly cited researchers’   Nigel Mackman, PhD Distinguished professor of medicine Pathology, and Pharmacology   29 Carolina faculty named ‘highly cited researchers’

Graduate students in the Aleman and Dominguez Labs won Abstract Achievement Awards for the upcoming ASH meeting. Kwame Forbes, PhD Candidate in Bioinformatics and Computational Biology for “Decoding the gene regulatory response to iron through multiomics.” Michael Sullivan, PhD Candidate in Pharmacology for “Intracellular iron levels alter the protein interactome of...

View BRC November 2025 Newsletter November 2025 Newsletter

Dr. Aleksei Martianov (PI: Dr. Wolfgang Bergmeier) was awarded the Richard T. Silver, MD Abstract Achievement Award for Myeloproliferative Neoplasms (MPNs). He will give an oral presentation entitled “Platelet priming in MPN triggers pro-thrombotic intermediate affinity state in αIIbβ3 integrin” on Sunday December 7, 2025 at 9:30 AM in Room...

On October 7, the Pathobiology and Translational Science graduate program had their annual student symposium. BRC trainees presented posters (YJ Choi – Wolberg Lab, Claire Reist – Flick Lab) and one gave a talk (Kylie Hutchison – Sparkenbaugh Lab). Alisa Wolberg, Steve Hur, and Erica were BRC faculty in attendance....

Nirupama Ramadas had a review paper published in RPTH “Emerging pathways in thromboinflammation of sickle cell disease: novel findings in disease pathogenesis” Sickle cell disease (SCD) is increasingly recognized as a chronic thromboinflammatory disorder, marked by persistent intravascular hemolysis, sustained endothelial activation, and multicellular aggregate formation. Free hemoglobin and heme...