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Matthew Karafin published the initial results of his prospective randomized clinical trial in JCI. Authors: Matthew S. Karafin, Abby S. Grier, Ross M. Fasano, Anton Ilich, David Wichlan, Ada Chang, Sonjile M. James, Hailly E. Butler, Oleg Kolupaev, Melissa C. Caughey, Daniel Stephenson, Julie A. Reisz, Nigel S. Key, Joshua J. Field, Jane...

Please join us for our Fall 2025 Blood Research Center Seminar Series, happening at 11am. Follow us on Linkedin for more information

Kylie Hutchison, a rising 2nd year PhD student within the Pathobiology and Translational Science program, was accepted into the UNC Certificate Program in Translational Medicine and selected as 1 of 4 trainees to receive funding from the certificate’s T32 training grant from the National Institute for General Medical Sciences (NIGMS) (NIH T32GM122741)....

Published article in Biophys Journal: Modeling platelet P2Y1/12 pathway to integrin activation. Authors: Patel KB, Bergmeier W, Fogelson AL.

Published article in JTH: Lack of overt bleeding or platelet dysfunction in a mouse model of vascular Ehlers-Danlos syndrome. Authors: Lee RH, Jones SR, Martyanov AA, Vander Ploeg MR, Sagues CF, Bergmeier W.

UNC’s Vital Signs highlighted work from the Wolberg laboratory (https://news.unchealthcare.org/2025/05/unc-study-offers-new-hope-for-safer-bleeding-treatments/) that is currently in press in Blood (https://ashpublications.org/blood/article/doi/10.1182/blood.2025028680/537391/Plasminogen-activation-and-plasmin-activity-are). This work showed that plasminogen activation and activity are not required to prevent venous thrombosis/thromboembolism, and suggests that use of antifibrinolytic therapy to decrease bleeding is not expected to increase thrombosis risk....

Dr. Yaqiu Sang, a postdoctoral fellow in Dr. Wolberg’s laboratory was featured in the Brinkhous Bulletin, the Department of Pathology and Laboratory Medicine’s monthly newsletter that reports exciting developments in the department. Dr. Sang was highlighted for her her contributions to the Wolberg lab including her recent paper published in...

Read more on this Case Study An 8-year-old female with sickle cell disease (SCD), hemoglobin SS genotype, global developmental delay, and pica established care shortly after moving from out of state. The patient and her family had been living in a weathered house. The child’s caregiver reported a recent history...

Dr. Alisa Wolberg received 2nd year of NIH R01 for “Interdisciplinary approach to elucidate modifiers of bleeding phenotype in factor XI deficiency”. More information

Dr. Matthew Flick received another year of funding from UVA “Novel mechanism underlying fibrinogen biogenesis in the endoplasmic reticulum”, an NIH funded project. NIH RePorter

View BRC May 2025 Newsletter May 2025 Newsletter