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Nirupama Ramadas had a review paper published in RPTH “Emerging pathways in thromboinflammation of sickle cell disease: novel findings in disease pathogenesis” Sickle cell disease (SCD) is increasingly recognized as a chronic thromboinflammatory disorder, marked by persistent intravascular hemolysis, sustained endothelial activation, and multicellular aggregate formation. Free hemoglobin and heme...

Ana Sachetto PhD is chair of the UNC Postdoctoral Association   The PDA is a social and collaborative space where postdoc volunteers come together to discuss relevant issues and try to find ways to improve the postdoc experience for the 800-1000 postdocs on UNC campus at any given time. Our...

Mackman Lab Publishes Two Articles https://www.rpthjournal.org/article/S2475-0379(25)00331-0/fulltext https://www.rpthjournal.org/article/S2475-0379(25)00340-1/fulltext   “Optimization of a Western blot protocol for the detection of low levels of tissue factor in human cells” The tissue factor (TF)/activated factor VII complex is the major activator of the coagulation system. TF is expressed by a variety of cells, including...

Meghana Malempati was awarded a UNC Summer Undergraduate Research Fellowship (SURF). The Summer Undergraduate Research Fellowship (SURF) program is one of many programs administered through the OUR, and it is designed to enhance the educational experience of undergraduates by engaging them in research opportunities. We expect to make about 60...

Ana Sachetto PhD was awarded a Top Poster Award and Early Career Travel Award at ISTH  2025 Congress   Each year, the ISTH Congress Scientific Committee rewards abstracts of outstanding quality and provides the submitting author with a Travel Award to attend the ISTH Congress. Three categories of Travel Award are distributed:...

Jane Little, MD, awarded RO1 from NIH   Hypoxemia with Sleep in Sickle Cell Anemia-Prevalence, Clinical and Cellular Impact & Response to Therapy: A Multi-Site Prospective Study Accessing New Collaborative Pathways   Sickle cell disease (SCD) arises from a gain-of function mutation of hemoglobin (Hb) in which deoxygenated sickle hemoglobin (deoxy-HbS) polymerizes, resulting in rigid, adhesive, and...

Alexandra Jane Borst, Clinical Associate Professor, and other team members awarded a large NIH U54 grant which is to support a rare-disease research consortium for vascular anomalies. It has many components and CHOP is the coordinating center, Borst is a PI for one of the main clinical projects, “Developing a...

Emily Grace Clark, mentored by Dr. Matthew Flick, received an F31 award, “Disrupting the Fibrin Shield to Combat Staphylococcus aureus BloodstreamInfections.”

UNC Hem/Onc Fellow Sam Short, MD and collaborators/mentors from the REGARDS study published two papers in JTH about stroke risk in atrial fibrillation. Improving stroke risk prediction in atrial fibrillation with  circulating biomarkers: the CHA2DS2-VASc–Biomarkers model (DOI: 10.1016/j.jtha.2025.06.007) Circulating biomarkers and ischemic stroke risk in adults with  atrial fibrillation taking anticoagulation: the...

Karin Leiderman, PhD and Dougald Monroe, PhD published in JTH. Mathematical analysis of emicizumab: affinity-driven complex formation and lipid-surface reactions. This study aimed to investigate emicizumab’s lipid-surface dependent mechanisms through mathematical modeling and biochemical assays. Read more here    

Erica Sparkenbaugh, PhD appointed the co-chair of the 2029 HTRS Scientific Symposium Planning Committee   We are excited to announce the Planning Committee for the HTRS 2027 Scientific Symposium, a dynamic three-day scientific conference dedicated to the advancement of clinical, translational, and discovery-based science research related to disorders of hemostasis...

Dr Monroe and colleagues published a study on the role of plasma inhibitors in regulating thrombin levels. Dougald Monroe, professor in the UNC Division of Hematology, and colleagues Allen Ma and Maureane Hoffman published their study on the contribution of four plasma inhibitors in regulating thrombin generation. The work was...