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Research Interests Gene regulation, RNA processing and RNA binding proteins in cell signaling and disease Research Synopsis The Dominguez lab studies how gene expression is controlled by proteins that bind RNA. RNA binding proteins control the way RNAs are transcribed, spliced, polyadenylated, exported, degraded, and translated. Areas of research include:...

Associate Professor, Research interests: I am interested in the interaction between endothelium and coagulation proteins as well as blood cells. I have recently presented data showing an increase of factor Xa generation on endothelium in the presence of emicizumab and factor IXa. I am active in investigating the mechanism of...

Our role in the Blood Research Center (BRC) is to provide a unique perspective on the contribution of coagulation and fibrinolytic factors to a wide spectrum of disease pathologies, independent of the traditional roles of these factors in bleeding and thrombosis. We utilize mouse models to analyze specific mechanisms by...

Research Interests My research interest focuses on the mechanisms of cancer-associated thrombosis and bleeding. My primary interest is mechanisms of pancreatic cancer-associated venous thrombosis because pancreatic cancer has one of the highest rates of venous thrombosis. I have found that tumor-derived tissue factor positive extracellular vesicles, neutrophils and neutrophil extracellular...

My research program is focused on identifying the bidirectional relationship between hemostatic system components and cardiometabolic diseases. Obesity (defined as body mass index >30) currently affects >650 billion adults and >340 million children worldwide. Obesity is characterized by a state of chronic low-grade inflammation and induces qualitative and quantitative changes...

My research broadly involves blood transfusion efficacy and quality. I am particularly interested in the variables that impact red cell unit quality and its effects on chronic transfusion protocols. The aim of my current multi-center randomized clinical studies is to improve transfusion efficacy for adults with sickle cell disease.

Bleeding and clotting disorders, and Hereditary Hemorrhagic Telangiectasia Dr. Raj Kasthuri is a clinician, researcher and clinical educator. Dr. Kasthuri’s clinical and research interests are in disorders of thrombosis and hemostasis, and Hereditary Hemorrhagic Telangiectasia. (HHT). Dr. Kasthuri is Associate Director for Clinical Research for the BRC. He is also...

I have been committed to building a strong translational research program to address novel challenges and questions related to blood and renal pathophysiology in rodents and humans. My work provided strong pre-clinical evidence that endothelin system significantly contributes to sickle cell renal pathophysiology. My collaborative efforts with Dr. Lebensburger identified...

My research interests are centered around platelet signaling and function. More specifically, I am focused on two main areas of platelet research: 1) the utility of platelet transfusion in various bleeding disorders, and 2) mechanisms regulating platelet lifespan in blood and platelet clearance in organs such as spleen and liver....

My research is focused on studying the influence of biochemical and biophysical mechanisms on blood coagulation, clot formation, and bleeding. My methodology involves the integration of mathematical, statistical, and experimental approaches to determine mechanisms underlying complex biological phenomena.

Dr. Little's clinical and research interests are in Sickle Cell Disease and erythropoiesis. We are interested in the physical properties of red cells, especially from people with sickle cell disease, under ambient and hypoxic conditions. We are using microfluidic devices in collaboration with colleagues at UNC and at CWRU to...

My research interests include, identification of polysaccharide-based receptor; structure and specificity of a heparan sulfate-based herpes simplex virus 1 receptor; drug targeting; gene therapy.