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Dr. Ma’s research interests center around detection of undiagnosed bleeding disorders, treatment of congenital and acquired bleeding disorders, as well as in treatment of immuno-hematologic disorders such as immune thrombocytopenic purpura and autoimmune hemolytic anemia. She is the director of the UNC adult hematology/oncology fellowship program and is focused on...

The Mackman lab studies the roles of tissue factor (TF), coagulation proteases and protease-activated receptors (PARs) in health and disease. We have established a variety of different disease models and have a larger number of transgenic mice deficient in different coagulation factors and PARs, as well as mice with low...

Dr. Moll is a clinician, clinical researcher and educator, with a particular focus on thrombosis and anticoagulation. His research interests include clinical trials on venous thromboembolism and better use of anticoagulants, antiphospholipid antibody syndrome, and postthrombotic syndrome.

As part of the Blood Research Center, we use our background in protein chemistry and enzyme kinetics to collaborate on studies looking at the molecular mechanisms that underlie both healthy hemostasis and the dysregulation of hemostasis seen in bleeding and thrombosis.

To date, my research interests have focused primarily on the investigation of the coagulation system in inflammatory disorders with a thrombotic phenotype. There is known to be a close interplay between inflammation and coagulation, however, not all inflammation predisposes to thrombosis. My work aims to help better understand the role...

I am the Director of the Francis Owen Blood Research Laboratory (FOBRL), the mission of which is to reduce human and animal suffering from bleeding, thrombosis and atherosclerosis by the study of unique, genetically-determined animal models of these diseases. The FOBRL was established in 1960 by Dr. Kenneth M. Brinkhous...

I am a clinical researcher focused on identifying modifiable risk factors to improve survival and quality of life of adults with sickle cell disease. My ongoing research interests are to characterize the phenomenon of occult hypoxia in high-risk subset of adults with sickle cell disease, and to explore the experience...

Research Interests My research focus is clinical research in the field of therapeutic apheresis, specifically thrombotic thrombocytopenic purpura (TTP). Although my research started quite small, using data and samples from UNC, it has grown to be incredibly collaborative through a number of professional organizations and relationships throughout the country and...

As a part of the Bergmeier research group my efforts are focused on understanding the intricacies of platelet signaling, primarily as it relates to thrombosis and hemostasis.

One area of interest is to investigate how the coagulation cascade contributes to the pathophysiology of neuroinflammation using mouse models of stroke and multiple sclerosis. We also study mechanisms of coagulation activation and clot formation in mouse models of sickle cell disease, and our goal is to identify the best...

My lab develops microfluidic models of the blood and lymphatic vasculature for basic science and translational purposes. Specific projects relevant to the Blood Research Center are: 1) Understanding the role of Notch receptor signaling in vascular endothelial adherens junction assembly and stability; 2) A nascent collaboration with Dr. Prabir Roy-Chaudhury...

In my research program, I use human genomics and multi-omics to understand inherited and environmental risk factors for cardiometabolic diseases, Alzheimer’s disease and related dementias, and related quantitative traits, including hematology and hemostasis phenotypes. I work to link genetic variants to function through integration with multi-omics data, including transcriptomic, methylation,...