Adam J. Kimple, MD, PhD
Associate Professor
EDUCATION
Fellowship
University of North Carolina Chapel Hill School of Medicine
Department of Otolaryngology/Head and Neck Surgery
Rhinology, Allergy & Endoscopic Skull Base Surgery
2017-2018
Residency
University of North Carolina Hospitals
Department of Otolaryngology/Head and Neck Surgery
2012-2017
Graduate/Medical School
University of North Carolina Chapel Hill School of Medicine
Chapel Hill, North Carolina
M.D. May 2012
University of North Carolina Chapel Hill
Department of Pharmacology
Chapel Hill, North Carolina
Ph.D. May 2010
Michigan State University
Department of Chemistry
East Lansing, Michigan
M.S. in Computational Chemistry, 2003
Undergraduate
Michigan State University
East Lansing, Michigan
B.S. in Chemistry with High Honors 2003
HONORS, AWARDS, and SCHOLARSHIPS
University of North Carolina – Hospital:
The Harold C. Pillsbury Leadership Award, 2017
The Amelia Drake Cool Under Pressure Award,
Edgar C. Garrabrandt Award – NC/SC Annual Meeting Resident Paper Competition, 2014
University of North Carolina:
Issac Hall Manning Award, 2012
Alexander Scholar, 2012
Lineberger Comprehensive Cancer Center Graduate Fellowship, 2009
Poster Presentation Award Winner – Lineberger Cancer Center Retreat, 2009
Scott Neil Schwirck Fellowship for Medical Student Research, 2006-2009
UNC School of Medicine International Fellowship, 2006
Carolina Summer Pharmacology Fellowship, 2003
Michigan State University:
College of Natural Science Faculty Distinguished Endowed Scholarship, 2003-2004
Cole Excellence Award, 2003-2004
Golden Key National Honor Society, 2001-2004
National Society of Collegiate Scholars, 2000-2004
William Sells Scholarship, 2002-2003
Mortar Board National Honor Society (Treasurer), 2002-2003
Howard Hughes Undergraduate Research Program, 1999-2003
Tower Guard Sophomore Honor Society, 2000-2001
Undergraduate Research Forum Merit Award, 2003
Honors College Research Fund Recipient, 2003
Ronald E. McNair Post Baccalaureate Achievement Program, 2002
BIBLIOGRAPHY & PRODUCTS OF SCHOLARSHIP
Chapters:
1) Kimple AJ, Ishman SL. Obstructive Sleep Disorders in Children. In: Snow JB, Wackym PA, editors. Ballenger’s Otorhinolaryngology Head and Neck Surgery. 18th ed. Lewiston, NY: People’s Medical Publishing House; 2015.
2) Siderovski DP, Kimple AJ. Regulator of G-Protein Signaling (RGS) Protein Family. In: Choi S, editor. Encyclopedia of signaling molecules. New York, New York: Springer; 2013. p. 3 volumes (xlv, 2029 pages).
3) Siderovski DP, Kimple AJ, Willard FS. Large G-Proteins. In: Begley TP, editor. Wiley Encyclopedia of Chemical Biology. Hoboken, New Jersey: John Wiley & Sons, Inc.; 2008.
Peer Reviewed Publications:
1) Kimple AJ, Patel SN. Aggressive tumor Aggressive Treatment. Int J of Radiation Oncology Biology & Physics. 2017 Dec 99(5):1062-1063. PMID: 29165275
2) Kimple AJ, Ferguson MO. Pneumocephalus after insertion of an inflatable nasal tampon for the management of epistaxis. Ear Nose Throat J. 2016 Apr-May; 95(4-5):172-4. PMID: 27140017
3) Kimple AJ, McClurg SW, Del Signore AG, Tomoum MO, Lin FC, Senior BA. Standardized Letters of Recommendation and Successful Match Into Otolaryngology. The Laryngoscope. 2016 May;126(5):1071-6. PMID: 2683997737
4) Shapiro AJ, Zariwala MA, Ferkol T, Davis SD, Sagel SD, Dell SD, Rosenfeld M, Olivier KN, Milla C, Daniel SJ, Kimple AJ, Manion M, Knowles MR, Leigh MW, Genetic Disorders of Mucociliary Clearance C. Diagnosis, monitoring, and treatment of primary ciliary dyskinesia: PCD foundation consensus recommendations based on state of the art review. Pediatr Pulmonol. 2016. 51(2):115-32. PMID: 26418604
5) Wallace IF, Berkman ND, Lohr KN, Harrison MF, Kimple AJ, Steiner MJ. Surgical treatments for otitis media with effusion: a systematic review. Pediatrics. 2014;133(2):296-311. PMID: 24394689.
6) Kimple AJ, Garland AL, Cohen SP, Setola V, Willard FS, Zielinski T, Lowery RG, Tarran R, Siderovski DP. RGS21, a regulator of taste and mucociliary clearance? The Laryngoscope. 2014;124(3):E56-63. PMID: 23908053.
7) Kimple AJ, Baldassari CM, Cohen AP, Landry A, Ishman SL. Polysomnographic results of prone versus supine positioning in micrognathia. International journal of pediatric otorhinolaryngology. 2014;78(12):2056-9. PMID: 25282304.
8) Kimple AJ, Austin GK, Shah RN, Welch CM, Funkhouser WK, Zanation AM, Shockley WW. Polymorphous low-grade adenocarcinoma: a case series and determination of recurrence. The Laryngoscope. 2014;124(12):2714-9. PMID: 25229805.
9) Bosch DE, Kimple AJ, Manning AJ, Muller RE, Willard FS, Machius M, Rogers SL, Siderovski DP. Structural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis. Structure. 2013;21(1):65-75. PMID: 23260656.
10) Rawal RB, Kimple AJ, Dugar DR, Zanation AM. Minimizing morbidity in endoscopic pituitary surgery: outcomes of the novel nasoseptal rescue flap technique. Otolaryngology–head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2012;147(3):434-7. PMID: 22492297.
11) Kimple AJ, Torres AD, Yang RZ, Kimple RJ. HPV-associated head and neck cancer: molecular and nano-scale markers for prognosis and therapeutic stratification. Sensors (Basel). 2012;12(4):5159-69. PMID: 22666080
12) Kimple AJ, Leight WD, Wheless SA, Zanation AM. Reducing nasal morbidity after skull base reconstruction with the nasoseptal flap: free middle turbinate mucosal grafts. The Laryngoscope. 2012;122(9):1920-4. PMID: 22926937.
13) Kimple AJ, Eliades S, Richmon J. Transoral robotic resection of a lingual thyroglossal duct cyst. Journal of Robotic Surgery. 2012;6(4):367-9.
14) Cohen SP, Buckley BK, Kosloff M, Garland AL, Bosch DE, Cheng G, Jr., Radhakrishna H, Brown MD, Willard FS, Arshavsky VY, Tarran R, Siderovski DP, Kimple AJ. Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. The Journal of biological chemistry. 2012;287(50):41706-19. PMID: 23095746.
15) Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP. A P-loop mutation in Galpha subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis. PLoS pathogens. 2012;8(2):e1002553. PMID: 22383884.
16) *Bosch DE, *Kimple AJ, Muller RE, Giguere PM, Machius M, Willard FS, Temple BR, Siderovski DP. Heterotrimeric G-protein signaling is critical to pathogenic processes in Entamoeba histolytica. PLoS pathogens. 2012;8(11):e1003040. PMID: 23166501.
17) *Bosch DE, *Kimple AJ, Sammond DW, Muller RE, Miley MJ, Machius M, Kuhlman B, Willard FS, Siderovski DP. Structural determinants of affinity enhancement between GoLoco motifs and G-protein alpha subunit mutants. The Journal of biological chemistry. 2011;286(5):3351-8. PMID: 21115486.
18) Nakamura K, Kimple AJ, Siderovski DP, Johnson GL. PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation. The Journal of biological chemistry. 2010;285(3):2077-89. PMID: 19903815.
19) Muller RE, Klein KR, Hutsell SQ, Siderovski DP, Kimple AJ. A homogeneous method to measure nucleotide exchange by alpha-subunits of heterotrimeric G-proteins using
fluorescence polarization. Assay and drug development technologies. 2010;8(5):621-4. PMID: 20662737.
20) Lambert NA, Johnston CA, Cappell SD, Kuravi S, Kimple AJ, Willard FS, Siderovski DP. Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(15):7066-71. PMID: 20351284.
21) Kimple AJ, Muller RE, Siderovski DP, Willard FS. A capture coupling method for the covalent immobilization of hexahistidine tagged proteins for surface plasmon resonance. Methods Mol Biol. 2010;627:91-100. PMID: 20217615
22) Hutsell SQ, Kimple RJ, Siderovski DP, Willard FS, Kimple AJ. High-affinity immobilization of proteins using biotin- and GST-based coupling strategies. Methods Mol Biol. 2010;627:75-90. PMID: 20217614
23) *Zielinski T, *Kimple AJ, Hutsell SQ, Koeff MD, Siderovski DP, Lowery RG. Two Galpha(i1) rate-modifying mutations act in concert to allow receptor-independent, steady-state measurements of RGS protein activity. Journal of biomolecular screening. 2009;14(10):1195-206. PMID: 19820068.
24) Willard FS, Willard MD, Kimple AJ, Soundararajan M, Oestreich EA, Li X, Sowa NA, Kimple RJ, Doyle DA, Der CJ, Zylka MJ, Snider WD, Siderovski DP. Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. PloS one. 2009;4(3):e4884. PMID: 19319189.
25) Preininger AM, Funk MA, Oldham WM, Meier SM, Johnston CA, Adhikary S, Kimple AJ, Siderovski DP, Hamm HE, Iverson TM. Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits. Biochemistry. 2009;48(12):2630-42. PMID: 19222191.
26) Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP. Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2). The Journal of biological chemistry. 2009;284(29):19402-11. PMID: 19478087.
27) Willard FS, Zheng Z, Guo J, Digby GJ, Kimple AJ, Conley JM, Johnston CA, Bosch D, Willard MD, Watts VJ, Lambert NA, Ikeda SR, Du Q, Siderovski DP. A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics. The Journal of biological chemistry. 2008;283(52):36698-710. PMID: 18984596.
28) Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP. Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(17):6457-62. PMID: 18434541.
29) Kimple AJ, Yasgar A, Hughes M, Jadhav A, Willard FS, Muller RE, Austin CP, Inglese J, Ibeanu GC, Siderovski DP, Simeonov A. A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction. Combinatorial chemistry & high throughput screening. 2008;11(5):396-409. PMID: 18537560.
30) Johnston CA, Willard MD, Kimple AJ, Siderovski DP, Willard FS. A sweet cycle for Arabidopsis G-proteins: Recent discoveries and controversies in plant G-protein signal transduction. Plant signaling & behavior. 2008;3(12):1067-76. PMID: 19513240.
31) Kimple AJ, Willard FS, Giguere PM, Johnston CA, Mocanu V, Siderovski DP. The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face. Biochimica et biophysica acta. 2007;1774(9):1213-20. PMID: 17660054.
32) Johnston CA, Taylor JP, Gao Y, Kimple AJ, Grigston JC, Chen JG, Siderovski DP, Jones AM, Willard FS. GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling. Proceedings of the National Academy of Sciences of the United States of America. 2007;104(44):17317-22. PMID: 17951432.
33) Sambi BS, Hains MD, Waters CM, Connell MC, Willard FS, Kimple AJ, Pyne S, Siderovski DP, Pyne NJ. The effect of RGS12 on PDGFbeta receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells. Cellular signalling. 2006;18(7):971-81. PMID: 16214305.
34) Willard FS, Kimple AJ, Johnston CA, Siderovski DP. A direct fluorescence-based assay for RGS domain GTPase accelerating activity. Analytical biochemistry. 2005;340(2):341-51. PMID: 15840508.
35) Uhlik MT, Temple B, Bencharit S, Kimple AJ, Siderovski DP, Johnson GL. Structural and evolutionary division of phosphotyrosine binding domains. Journal of molecular biology. 2005;345(1):1-20. PMID: 15567406.
36) Krishnamurthy H, Lou H, Kimple AJ, Vieille C, Cukier RI. Associative mechanism for phosphoryl transfer: a molecular dynamics simulation of Escherichia coli adenylate kinase complexed with its substrates. Proteins. 2005;58(1):88-100. PMID: 15521058.
37) Willard FS, Kimple RJ, Kimple AJ, Johnston CA, Siderovski DP. Fluorescence-based assays for RGS box function. Methods in enzymology. 2004;389:56-71. PMID: 15313559