Department of Genetics Publications for February 2026

Epigenetic Age Acceleration and Hearing Function in US Older Adults. 

West JS, Chen Q, Smith SL, Bao J, Zou F, Li YJ, Jiang R.

Ear Hear. 2026 Feb 6. doi: 10.1097/AUD.0000000000001797. Online ahead of print.

PMID: 41645414

Shared PRAME epitopes are T-cell targets in NUT carcinoma. 

Jensen JL, Peterson SK, Sambade MJ, Alley JR, Yu S, Kinjo T, Bennett SN, Vensko SP 2nd, Shabrang M, Debetta JD, Geyer JK, Price BA, Nickel KP, Kimple RJ, Kotecha RS, Herring LE, Davis IJ, Wang JR, French CA, Kuhlman B, Weiss JM, Rubinsteyn A, Vincent BG.

J Immunother Cancer. 2026 Feb 5;14(2):e013539. doi: 10.1136/jitc-2025-013539.

PMID: 41644270

Identifying Locally Recurrent Versus Second Primary Breast Cancer: Genomic Versus Clinical Criteria from Carolina Breast Cancer Study Phase III. 

Van Alsten SC, Love MI, Calhoun BC, Butler EN, Pfefferle AD, Kirk EL, Halloran CS, Zipple IW, Perou CM, Carey LA, Hoadley KA, Troester MA.

Cancer Epidemiol Biomarkers Prev. 2026 Feb 3;35(2):311-320. doi: 10.1158/1055-9965.EPI-25-1298.

PMID: 41324404

Epidemiologic and Bacterial Factors Facilitating Long-term Transmission of Multidrug-Resistant Tuberculosis in Shanghai, China. 

Lu X, Jiang Y, Zhang R, Zhang Y, Li J, Wang L, Ye Q, Hou R, Lu Y, Zhu X, Ji Y, Gan M, Li M, Liu Q, Shen X, Yang C.

Clin Infect Dis. 2026 Feb 4;81(6):1115-1125. doi: 10.1093/cid/ciaf313.

PMID: 40576551

eQTL in diseased colon tissue identifies potential target genes associated with IBD. 

Nishiyama NC, Silverstein S, Darlington K, Kennedy Ng MM, Clough KM, Bauer M, Beasley C, Bharadwaj A, Ganesan R, Kapadia MR, Lau G, Lian G, Rahbar R, Sadiq TS, Schaner MR, Stem J, Friton J, Faubion WA Jr, Sheikh SZ, Furey TS.

Nat Commun. 2026 Feb 13. doi: 10.1038/s41467-026-69364-6. Online ahead of print.

PMID: 41688467

Long-read whole-transcriptome sequencing and selective gene panel profiling enable sensitive detection of fusion oncogenes in pediatric B-cell acute lymphoblastic leukemia. 

Lin J, Opoku KB, Litzow MR, Paietta E, Pui CH, Jeha S, Roberts KG, Mullighan CG, Alexander TB, Wang JR.

J Mol Diagn. 2026 Feb 10:S1525-1578(26)00021-8. doi: 10.1016/j.jmoldx.2026.01.007. Online ahead of print.

PMID: 41679504

Large language models for bioinformatics. 

Ruan W, Lyu Y, Zhang J, Cai J, Shu P, Ge Y, Lu Y, Gao S, Wang Y, Wang P, Zhao L, Wang T, Liu Y, Fang L, Liu Z, Liu Z, Li Y, Wu Z, Chen J, Jiang H, Pan Y, Yang Z, Chen J, Liang S, Zhang W, Ma T, Dou Y, Zhang J, Gong X, Gan Q, Zou Y, Chen Z, Qian Y, Yu S, Lu J, Song K, Wang X, Sikora A, Li G, Li X, Li Q, Wang Y, Zhang L, Abate Y, He L, Zhong W, Liu R, Huang C, Liu W, Shen Y, Ma P, Zhu H, Yan Y, Zhu D, Liu T.

Quant Biol. 2025 Sep 28;14(1):e70014. doi: 10.1002/qub2.70014. eCollection 2026 Mar.

PMID: 41676319

Recombination and the role of pseudo-overdominance in polyploid evolution. 

Booker WW, Schrider DR.

G3 (Bethesda). 2026 Feb 20:jkag048. doi: 10.1093/g3journal/jkag048. Online ahead of print.

PMID: 41721503

Hepatocyte-targeted Bap1 reduction in the liver primes an inflammatory transcriptional response. 

Nenad WC, Kuhlers PC, Sturgill IR, Biju I, Bucklan M, Hernandez L, Zhu LC, Hoadley KA, Raab JR.

G3 (Bethesda). 2026 Feb 19:jkag047. doi: 10.1093/g3journal/jkag047. Online ahead of print.

PMID: 41712409

DeCAF defines clinical fibroblast subtypes and multidimensional tumor-stroma crosstalk shaping prognosis and immunotherapy response. 

Peng XL, McCabe IC, Kharitonova EV, Xu Y, Zhao RT, Luan C, Kearney JF, Kren NP, Hariharan A, Lee JJ, Su J, Chan PS, Morrison AB, LaBella ME, Herera Loeza SG, Cliff A, Kim HJ, Pylayeva-Gupta Y, Tsai S, Belt BA, Panni RZ, Linehan DC, Gomez SM, Damrauer JS, Iuga AC, Kim WY, Rashid NU, Yeh JJ.

Cell Rep Med. 2026 Feb 17;7(2):102611. doi: 10.1016/j.xcrm.2026.102611.

PMID: 41707654

Talimogene laherparepvec and atezolizumab in HER2-negative breast cancer following neoadjuvant chemotherapy: a window-of-opportunity phase II trial (SOLTI-1503 PROMETEO). 

Pascual T, Vidal M, Cejalvo JM, Vega E, Sanfeliu E, Villacampa G, Ganau S, Parreño AMJ, Zamora E, Miranda I, Delgado A, Bermejo B, Seguí E, Brasó-Maristanty F, de la Cruz-Merino L, Juan M, Galván P, Gonzàlez-Farré X, Chillara S, Villagrasa P, Pfefferle AD, O’Connell CE, Ferrero-Cafiero JM, Oliveira M, Perou CM, Prat A.

Nat Commun. 2026 Feb 16. doi: 10.1038/s41467-026-69222-5. Online ahead of print.

PMID: 41698899

UTX coordinates TCF1 and STAT3 to control progenitor CD8+ T cell fate in autoimmune diabetes. 

Chen HC, Bang MF, Wang HH, Shpargel KB, Kohn LA, Sailer D, Zhang S, McCarthy EC, Seyedsadr M, Stevens S, Pham CL, Zhou Z, Yin X, Wilkinson NM, Peluso EM, Bustillos C, Ortega JG, Yang L, Buzzelli AA, Capati RC, Chia DJ, Mittelman SD, Reh CM, Whitmire JK, Lechner MG, Hugo W, Su MA.

J Clin Invest. 2025 Dec 16;136(4):e196325. doi: 10.1172/JCI196325. eCollection 2026 Feb 16.

PMID: 41401033

 

96 sample parallel acoustic fragmentation for high throughput next generation sequencing library preparation. 

Mehrab-Mohseni M, Bautista KJB, Liu Y, Maldonado-Rosado EE, Zheng H, Niederhuber MJ, Rosen JD, Carroll MD, Velasco B, Tsuruta JK, Kim J, Marron JS, Haaland PD, Kasoji SK, Mieczkowski PA, Hepperla AJ, Dayton PA, Pattenden SG.

PLoS One. 2026 Feb 17;21(2):e0341139. doi: 10.1371/journal.pone.0341139. eCollection 2026.

PMID: 41701697

Multidimensional integrative analysis unveils genetic architecture, risk factors, and health consequences of brain aging. 

Huang Y, Li Z, Yuan Y, Wang M, Zhang M, Li X, Li Z, Li X, Li W.

J Adv Res. 2026 Feb 17:S2090-1232(26)00161-X. doi: 10.1016/j.jare.2026.02.029. Online ahead of print.

PMID: 41713737

Systematic review: The role of bicarbonate therapy after urinary diversion. 

Desai S, Frisbie J, Moreton E, Nielsen M, Bjurlin M, Tan HJ, Smith A, Gessner KH.

Bladder Cancer. 2026 Feb 16;12(1):23523735261424587. doi: 10.1177/23523735261424587. eCollection 2026 Jan-Mar.

PMID: 41710209

The Meaning of Screening: Exploring user experience of an aneuploidy screening educational game. 

Riches NO, Johnson EP, Subramanian A, Vora NL, Kaphingst KA, Junge J, Valle M, Rothwell E.

J Genet Couns. 2026 Feb;35(1):e70183. doi: 10.1002/jgc4.70183.

PMID: 41705891

Canopy2: Tumor Phylogeny Inference by Bulk DNA and Single-Cell RNA Sequencing. 

Weideman AMK, Wang R, Ibrahim JG, Jiang Y.

Stat Biosci. 2026;18(1):68-110. doi: 10.1007/s12561-024-09466-1. Epub 2025 Jan 8.

PMID: 41694548

Alterations of Plasma Metabolites Associated with Sickle Cell Trait. 

Cai Y, Surapaneni A, Vasconcelos AG, Johnson M, Hsu L, Sun W, Kooperberg C, Yu B, Yeo WJ, Auer PL, Grams ME, Franceschini N, Raffield LM, Reiner AP.

Clin J Am Soc Nephrol. 2026 Feb 27. doi: 10.2215/CJN.0000001015. Online ahead of print.

PMID: 41758580

Rethinking Immune Studies: Population-Level Immune Variations and the Path Forward. 

Hysong MR, Memili A, Delaney JA, Ekunwe L, Huber S, Reiner AP, Patsy BM, Sitlani CM, Tracy RP, Taylor KD, Olson NC, Doyle MF, Raffield LM.

J Gerontol A Biol Sci Med Sci. 2026 Feb 25:glag055. doi: 10.1093/gerona/glag055. Online ahead of print.

PMID: 41741349

CNS-targeted NLRP3 Inhibition by NT-0527 confers therapeutic advantage in a CAPS mouse model. 

Koller BH, Nguyen M, Doedens JR, Harrison D, Clarke N, Watt AP, Gabel CA.

J Neuroinflammation. 2026 Feb 21. doi: 10.1186/s12974-026-03731-4. Online ahead of print.

PMID: 41723527

 

Scalable and accurate rare-variant association tests for whole genome sequencing time-to-event analysis in large biobanks. 

Song S, Li X, Zhou H, Li Z, Lin X.

Proc Natl Acad Sci U S A. 2026 Mar 3;123(9):e2525288123. doi: 10.1073/pnas.2525288123. Epub 2026 Feb 27.

PMID: 41758668

Molecular Echoes of Mucus Plugging in COPD. 

O’Neal WK, Boucher RC.

Am J Respir Crit Care Med. 2026 Jan 23:aamaf101. doi: 10.1093/ajrccm/aamaf101. Online ahead of print.

PMID: 41738146

Intrathecal idursulfase-IT in children younger than 3 years with neuronopathic mucopolysaccharidosis II in a single-arm, open-label, phase 2/3 substudy and extension. 

Muenzer J, Burton BK, Harmatz P, Gutiérrez-Solana LG, Ruiz-Garcia M, Jones SA, Guffon N, Inbar-Feigenberg M, Bratkovic D, Rust S, Hale M, Wu Y, Yee KS, Whiteman DAH, Alexanderian D.

JIMD Rep. 2026 Feb 22;67(2):e12443. doi: 10.1002/jmd2.12443. eCollection 2026 Mar.

PMID: 41737901

Systematic benchmarking demonstrates large language models have not reached the diagnostic accuracy of traditional rare-disease decision support tools. 

Reese JT, Chimirri L, Bridges Y, Danis D, Caufield JH, Gargano MA, Kroll C, Schmeder A, Liu F, Wissink K, McMurry JA, Graefe ASL, Niyonkuru E, Korn DR, Casiraghi E, Valentini G, Jacobsen JOB, Haendel M, Smedley D, Mungall CJ, Robinson PN.

Eur J Hum Genet. 2026 Feb 24. doi: 10.1038/s41431-026-02054-5. Online ahead of print.

PMID: 41735669

PETScan: score-based genome-wide association analysis of RNA-Seq and ATAC-Seq data. 

Hao Y, Kafri T, Zou F.

Bioinformatics. 2026 Feb 3;42(2):btaf672. doi: 10.1093/bioinformatics/btaf672.

PMID: 41719189

Early life phthalate and replacement plasticizer exposures and changes in early childhood brain functional connectivity and structural morphology. 

Engel SM, Li T, Werder EJ, Liu CW, Pacyga DC, Thistle J, Yin W, Rager JE, Wu Z, Sun Z, Wang L, Bankoski A, Gilmore JH, Piven J, Li G, Zhu H, Lu K, Lin W.

Environ Int. 2026 Feb;208:110119. doi: 10.1016/j.envint.2026.110119. Epub 2026 Feb 3.

PMID: 41671672