Department of Genetics Publications for July 30th – August 12th, 2023

Department of Genetics faculty, postdocs, students and collaborators published 9 papers during July 30th – August 12th, 2023.

Differences in the Circulating Proteome in Individuals with versus without Sickle Cell Trait. 

Cai Y, Franceschini N, Surapaneni A, Garrett ME, Tahir UA, Hsu L, Telen MJ, Yu B, Tang H, Li Y, Liu S, Gerszten RE, Coresh J, Manson JE, Wojcik GL, Kooperberg C, Auer PL, Foster MW, Grams ME, Ashley-Koch AE, Raffield LM, Reiner AP.

Clin J Am Soc Nephrol. 2023 Aug 3. doi: 10.2215/CJN.0000000000000257. Online ahead of print.

PMID: 37533140

 

Genetic insights into resting heart rate and its role in cardiovascular disease. 

van de Vegte YJ, Eppinga RN, van der Ende MY, Hagemeijer YP, Mahendran Y, Salfati E, Smith AV, Tan VY, Arking DE, Ntalla I, Appel EV, Schurmann C, Brody JA, Rueedi R, Polasek O, Sveinbjornsson G, Lecoeur C, Ladenvall C, Zhao JH, Isaacs A, Wang L, Luan J, Hwang SJ, Mononen N, Auro K, Jackson AU, Bielak LF, Zeng L, Shah N, Nethander M, Campbell A, Rankinen T, Pechlivanis S, Qi L, Zhao W, Rizzi F, Tanaka T, Robino A, Cocca M, Lange L, Müller-Nurasyid M, Roselli C, Zhang W, Kleber ME, Guo X, Lin HJ, Pavani F, Galesloot TE, Noordam R, Milaneschi Y, Schraut KE, den Hoed M, Degenhardt F, Trompet S, van den Berg ME, Pistis G, Tham YC, Weiss S, Sim XS, Li HL, van der Most PJ, Nolte IM, Lyytikäinen LP, Said MA, Witte DR, Iribarren C, Launer L, Ring SM, de Vries PS, Sever P, Linneberg A, Bottinger EP, Padmanabhan S, Psaty BM, Sotoodehnia N, Kolcic I; DCCT/EDIC Research Group; Arnar DO, Gudbjartsson DF, Holm H, Balkau B, Silva CT, Newton-Cheh CH, Nikus K, Salo P, Mohlke KL, Peyser PA, Schunkert H, Lorentzon M, Lahti J, Rao DC, Cornelis MC, Faul JD, Smith JA, Stolarz-Skrzypek K, Bandinelli S, Concas MP, Sinagra G, Meitinger T, Waldenberger M, Sinner MF, Strauch K, Delgado GE, Taylor KD, Yao J, Foco L, Melander O, de Graaf J, de Mutsert R, de Geus EJC, Johansson Å, Joshi PK, Lind L, Franke A, Macfarlane PW, Tarasov KV, Tan N, Felix SB, Tai ES, Quek DQ, Snieder H, Ormel J, Ingelsson M, Lindgren C, Morris AP, Raitakari OT, Hansen T, Assimes T, Gudnason V, Timpson NJ, Morrison AC, Munroe PB, Strachan DP, Grarup N, Loos RJF, Heckbert SR, Vollenweider P, Hayward C, Stefansson K, Froguel P, Groop L, Wareham NJ, van Duijn CM, Feitosa MF, O’Donnell CJ, Kähönen M, Perola M, Boehnke M, Kardia SLR, Erdmann J, Palmer CNA, Ohlsson C, Porteous DJ, Eriksson JG, Bouchard C, Moebus S, Kraft P, Weir DR, Cusi D, Ferrucci L, Ulivi S, Girotto G, Correa A, Kääb S, Peters A, Chambers JC, Kooner JS, März W, Rotter JI, Hicks AA, Smith JG, Kiemeney LALM, Mook-Kanamori DO, Penninx BWJH, Gyllensten U, Wilson JF, Burgess S, Sundström J, Lieb W, Jukema JW, Eijgelsheim M, Lakatta ELM, Cheng CY, Dörr M, Wong TY, Sabanayagam C, Oldehinkel AJ, Riese H, Lehtimäki T, Verweij N, van der Harst P.

Nat Commun. 2023 Aug 2;14(1):4646. doi: 10.1038/s41467-023-39521-2.

PMID: 37532724 Free PMC article.

 

A Novel ENU-Induced Mfn2 Mutation Causes Motor Deficits in Mice without Causing Peripheral Neuropathy. 

Hines TJ, Bailey J, Liu H, Guntur AR, Seburn KL, Pratt SL, Funke JR, Tarantino LM, Burgess RW.

Biology (Basel). 2023 Jul 3;12(7):953. doi: 10.3390/biology12070953.

PMID: 37508383 Free PMC article.

 

Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice. 

Brown AJ, Won JJ, Wolfisberg R, Fahnøe U, Catanzaro N, West A, Moreira FR, Nogueira Batista M, Ferris MT, Linnertz CL, Leist SR, Nguyen C, De la Cruz G, Midkiff BR, Xia Y, Evangelista MD, Montgomery SA, Billerbeck E, Bukh J, Scheel TKH, Rice CM, Sheahan TP.

Hepatology. 2023 Aug 7. doi: 10.1097/HEP.0000000000000547. Online ahead of print.

PMID: 37540195

 

Cross-National and Cross-Generational Evidence That Educational Attainment May Slow the Pace of Aging in European-Descent Individuals. 

Sugden K, Moffitt TE, Arpawong TE, Arseneault L, Belsky DW, Corcoran DL, Crimmins EM, Hannon E, Houts R, Mill JS, Poulton R, Ramrakha S, Wertz J, Williams BS, Caspi A.

J Gerontol B Psychol Sci Soc Sci. 2023 Aug 2;78(8):1375-1385. doi: 10.1093/geronb/gbad056.

PMID: 37058531

 

Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study. 

Keshawarz A, Bui H, Joehanes R, Ma J, Liu C, Huan T, Hwang SJ, Tejada B, Sooda M, Courchesne P, Munson PJ, Demirkale CY, Yao C, Heard-Costa NL, Pitsillides AN, Lin H, Liu CT, Wang Y, Peloso GM, Lundin J, Haessler J, Du Z, Cho M, Hersh CP, Castaldi P, Raffield LM, Wen J, Li Y, Reiner AP, Feolo M, Sharopova N, Vasan RS, DeMeo DL, Carson AP, Kooperberg C, Levy D.

Sci Rep. 2023 Aug 10;13(1):12952. doi: 10.1038/s41598-023-39936-3.

PMID: 37563237

 

Genetic examination of hematological parameters in SARS-CoV-2 infection and COVID-19. 

Sun Q, Rowland B, Wang W, Miller-Fleming TW, Cox N, Graff M, Faucon A, Shuey MM, Blue EE, Auer P, Li Y, Sankaran VG, Reiner AP, Raffield LM.

Blood Cells Mol Dis. 2023 Nov;103:102782. doi: 10.1016/j.bcmd.2023.102782. Epub 2023 Jul 20.

PMID: 37558590

 

Prophecy or Empiricy? Clinical value of predicting vs determining genetic variant functions. 

Brunklaus A, George AL Jr, Lal D, Heinzen EL, Goldman AM.

Epilepsia. 2023 Aug 10. doi: 10.1111/epi.17743. Online ahead of print.

PMID: 37562820 No abstract available.

 

Statistical Learning Methods for Neuroimaging Data Analysis with Applications. 

Zhu H, Li T, Zhao B.

Annu Rev Biomed Data Sci. 2023 Aug 10;6:73-104. doi: 10.1146/annurev-biodatasci-020722-100353. Epub 2023 Apr 26.

PMID: 37127052 Review.