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UNC Genetics PublicationsDepartment of Genetics faculty, postdocs, students and collaborators published 11 papers during June 19th – July 2nd, 2022.

 

Long-range chromosomal interactions increase and mark repressed gene expression during adipogenesis. 

Garske KM, Comenho C, Pan DZ, Alvarez M, Mohlke K, Laakso M, Pietiläinen KH, Pajukanta P.

Epigenetics. 2022 Jun 23:1-14. doi: 10.1080/15592294.2022.2088145. Online ahead of print.

PMID: 35746833

 

Distinct reproductive risk profiles for intrinsic-like breast cancer subtypes: pooled analysis of population-based studies. 

Jung AY, Ahearn TU, Behrens S, Middha P, Bolla MK, Wang Q, Arndt V, Aronson KJ, Augustinsson A, Beane Freeman LE, Becher H, Brenner H, Canzian F, Carey LA; CTS Consortium, Czene K, Eliassen AH, Eriksson M, Evans DG, Figueroa JD, Fritschi L, Gabrielson M, Giles GG, Guénel P, Hadjisavvas A, Haiman CA, Håkansson N, Hall P, Hamann U, Hoppe R, Hopper JL, Howell A, Hunter DJ, Hüsing A, Kaaks R, Kosma VM, Koutros S, Kraft P, Lacey JV, Le Marchand L, Lissowska J, Loizidou MA, Mannermaa A, Maurer T, Murphy RA, Olshan AF, Olsson H, Patel AV, Perou CM, Rennert G, Shibli R, Shu XO, Southey MC, Stone J, Tamimi RM, Teras LR, Troester MA, Truong T, Vachon CM, Wang SS, Wolk A, Wu AH, Yang XR, Zheng W, Dunning AM, Pharoah PDP, Easton DF, Milne RL, Chatterjee N, Schmidt MK, García-Closas M, Chang-Claude J.

J Natl Cancer Inst. 2022 Jun 20:djac117. doi: 10.1093/jnci/djac117. Online ahead of print.

PMID: 35723569

 

Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses. 

Yang X, Dickmander RJ, Bayati A, Taft-Benz SA, Smith JL, Wells CI, Madden EA, Brown JW, Lenarcic EM, Yount BL Jr, Chang E, Axtman AD, Baric RS, Heise MT, McPherson PS, Moorman NJ, Willson TM.

ACS Chem Biol. 2022 Jun 19. doi: 10.1021/acschembio.2c00378. Online ahead of print.

PMID: 35723434

 

Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies. 

Gorski M, Rasheed H, Teumer A, Thomas LF, Graham SE, Sveinbjornsson G, Winkler TW, Günther F, Stark KJ, Chai JF, Tayo BO, Wuttke M, Li Y, Tin A, Ahluwalia TS, Ärnlöv J, Åsvold BO, Bakker SJL, Banas B, Bansal N, Biggs ML, Biino G, Böhnke M, Boerwinkle E, Bottinger EP, Brenner H, Brumpton B, Carroll RJ, Chaker L, Chalmers J, Chee ML, Chee ML, Cheng CY, Chu AY, Ciullo M, Cocca M, Cook JP, Coresh J, Cusi D, de Borst MH, Degenhardt F, Eckardt KU, Endlich K, Evans MK, Feitosa MF, Franke A, Freitag-Wolf S, Fuchsberger C, Gampawar P, Gansevoort RT, Ghanbari M, Ghasemi S, Giedraitis V, Gieger C, Gudbjartsson DF, Hallan S, Hamet P, Hishida A, Ho K, Hofer E, Holleczek B, Holm H, Hoppmann A, Horn K, Hutri-Kähönen N, Hveem K, Hwang SJ, Ikram MA, Josyula NS, Jung B, Kähönen M, Karabegović I, Khor CC, Koenig W, Kramer H, Krämer BK, Kühnel B, Kuusisto J, Laakso M, Lange LA, Lehtimäki T, Li M, Lieb W; Lifelines cohort study, Lind L, Lindgren CM, Loos RJF, Lukas MA, Lyytikäinen LP, Mahajan A, Matias-Garcia PR, Meisinger C, Meitinger T, Melander O, Milaneschi Y, Mishra PP, Mononen N, Morris AP, Mychaleckyj JC, Nadkarni GN, Naito M, Nakatochi M, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Nutile T, O’Donoghue ML, O’Connell J, Olafsson I, Orho-Melander M, Parsa A, Pendergrass SA, Penninx BWJH, Pirastu M, Preuss MH, Psaty BM, Raffield LM, Raitakari OT, Rheinberger M, Rice KM, Rizzi F, Rosenkranz AR, Rossing P, Rotter JI, Ruggiero D, Ryan KA, Sabanayagam C, Salvi E, Schmidt H, Schmidt R, Scholz M, Schöttker B, Schulz CA, Sedaghat S, Shaffer CM, Sieber KB, Sim X, Sims M, Snieder H, Stanzick KJ, Thorsteinsdottir U, Stocker H, Strauch K, Stringham HM, Sulem P, Szymczak S, Taylor KD, Thio CHL, Tremblay J, Vaccargiu S, van der Harst P, van der Most PJ, Verweij N, Völker U, Wakai K, Waldenberger M, Wallentin L, Wallner S, Wang J, Waterworth DM, White HD, Willer CJ, Wong TY, Woodward M, Yang Q, Yerges-Armstrong LM, Zimmermann M, Zonderman AB, Bergler T, Stefansson K, Böger CA, Pattaro C, Köttgen A, Kronenberg F, Heid IM.

Kidney Int. 2022 Jun 15:S0085-2538(22)00454-9. doi: 10.1016/j.kint.2022.05.021. Online ahead of print.

PMID: 35716955

 

TP53, CDKN2A/P16, and NFE2L2/NRF2 regulate the incidence of pure- and combined-small cell lung cancer in mice. 

Hamad SH, Montgomery SA, Simon JM, Bowman BM, Spainhower KB, Murphy RM, Knudsen ES, Fenton SE, Randell SH, Holt JR, Hayes DN, Witkiewicz AK, Oliver TG, Major MB, Weissman BE.

Oncogene. 2022 Jun;41(25):3423-3432. doi: 10.1038/s41388-022-02348-0. Epub 2022 May 16.

PMID: 35577980

 

Convergence and Divergence of Rare Genetic Disorders on Brain Phenotypes: A Review. 

Raznahan A, Won H, Glahn DC, Jacquemont S.

JAMA Psychiatry. 2022 Jun 29. doi: 10.1001/jamapsychiatry.2022.1450. Online ahead of print.

PMID: 35767289

 

A comprehensive comparison on cell-type composition inference for spatial transcriptomics data. 

Chen J, Liu W, Luo T, Yu Z, Jiang M, Wen J, Gupta GP, Giusti P, Zhu H, Yang Y, Li Y.

Brief Bioinform. 2022 Jun 27:bbac245. doi: 10.1093/bib/bbac245. Online ahead of print.

PMID: 35753702

 

Acetaldehyde makes a distinct mutation signature in single-stranded DNA. 

Vijayraghavan S, Porcher L, Mieczkowski PA, Saini N.

Nucleic Acids Res. 2022 Jul 1:gkac570. doi: 10.1093/nar/gkac570. Online ahead of print.

PMID: 35776120

 

An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma. 

Zhou J, Simon JM, Liao C, Zhang C, Hu L, Zurlo G, Liu X, Fan C, Hepperla A, Jia L, Tcheuyap VT, Zhong H, Elias R, Ye J, Henne WM, Kapur P, Nijhawan D, Brugarolas J, Zhang Q.

Mol Cell. 2022 Jun 15:S1097-2765(22)00539-1. doi: 10.1016/j.molcel.2022.06.003. Online ahead of print.

PMID: 35764091

 

Derivation and validation of risk prediction for posttraumatic stress symptoms following trauma exposure. 

Kim R, Lin T, Pang G, Liu Y, Tungate AS, Hendry PL, Kurz MC, Peak DA, Jones J, Rathlev NK, Swor RA, Domeier R, Velilla MA, Lewandowski C, Datner E, Pearson C, Lee D, Mitchell PM, McLean SA, Linnstaedt SD.

Psychol Med. 2022 Jul 1:1-10. doi: 10.1017/S003329172200191X. Online ahead of print.

PMID: 35775366

 

Copy Number Variation Detection by Single-Cell DNA Sequencing with SCOPE. 

Wang R, Jiang Y.

Methods Mol Biol. 2022;2493:279-288. doi: 10.1007/978-1-0716-2293-3_18.

PMID: 35751822