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UNC Genetics PublicationsDepartment of Genetics faculty, postdocs, students and collaborators published 9 papers during May 7th – 20th, 2023.

Transcriptional diversity in specific synaptic gene sets discriminates cortical neuronal identity. 

Roig Adam A, Martínez-López JA, van der Spek SJF; SYNGO consortium; Sullivan PF, Smit AB, Verhage M, Hjerling-Leffler J.

Biol Direct. 2023 May 9;18(1):22. doi: 10.1186/s13062-023-00372-y.

PMID: 37161421

 

Human T cells efficiently control RSV infection. 

De C, Pickles RJ, Yao W, Liao B, Boone AE, Choi M, Battaglia DM, Askin FB, Whitmire JK, Silvestri G, Garcia JV, Wahl A.

JCI Insight. 2023 May 9:e168110. doi: 10.1172/jci.insight.168110. Online ahead of print.

PMID: 37159271

 

Timesweeper: Accurately Identifying Selective Sweeps Using Population Genomic Time Series. 

Whitehouse LS, Schrider DR.

Genetics. 2023 May 9:iyad084. doi: 10.1093/genetics/iyad084. Online ahead of print.

PMID: 37157914

 

The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes. 

Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch AJ, Zhu W, Petty L, Yi X, Cole JB, Udler MS, Dornbos P, Porneala B, DiCorpo D, Liu CT, Li JH, Szczerbiński L, Kaur V, Kim J, Lu Y, Martin A, Eizirik DL, Marchetti P, Marselli L, Chen L, Srinivasan S, Todd J, Flannick J, Gubitosi-Klug R, Levitsky L, Shah R, Kelsey M, Burke B, Dabelea DM, Divers J, Marcovina S, Stalbow L, Loos RJF, Darst BF, Kooperberg C, Raffield LM, Haiman C, Sun Q, McCormick JB, Fisher-Hoch SP, Ordoñez ML, Meigs J, Baier LJ, González-Villalpando C, González-Villalpando ME, Orozco L, García-García L, Moreno-Estrada A; Mexican Biobank; Aguilar-Salinas CA, Tusié T, Dupuis J, Ng MCY, Manning A, Highland HM, Cnop M, Hanson R, Below J, Florez JC, Leong A, Mercader JM.

Diabetologia. 2023 May 6. doi: 10.1007/s00125-023-05912-9. Online ahead of print.

PMID: 37148359

 

Genome-wide maps of UVA and UVB mutagenesis in yeast reveal distinct causative lesions and mutational strand asymmetries. 

Laughery MF, Plummer DA, Wilson HE, Vandenberg BN, Mitchell D, Mieczkowski PA, Roberts SA, Wyrick JJ.

Genetics. 2023 May 12:iyad086. doi: 10.1093/genetics/iyad086. Online ahead of print.

PMID: 37170598

 

LENS: Landscape of Effective Neoantigens Software. 

Vensko SP, Olsen K, Bortone D, Smith CC, Chai S, Beckabir W, Fini M, Jadi O, Rubinsteyn A, Vincent BG.

Bioinformatics. 2023 May 15:btad322. doi: 10.1093/bioinformatics/btad322. Online ahead of print.

PMID: 37184881

 

Genetic Modifiers of Cystic Fibrosis Lung Disease Severity: Whole-Genome Analysis of 7,840 Patients. 

Zhou YH, Gallins PJ, Pace RG, Dang H, Aksit MA, Blue EE, Buckingham KJ, Collaco JM, Faino AV, Gordon WW, Hetrick KN, Ling H, Liu W, Onchiri FM, Pagel K, Pugh EW, Raraigh KS, Rosenfeld M, Sun Q, Wen J, Li Y, Corvol H, Strug LJ, Bamshad MJ, Blackman SM, Cutting GR, Gibson RL, O’Neal WK, Wright FA, Knowles MR.

Am J Respir Crit Care Med. 2023 May 15;207(10):1324-1333. doi: 10.1164/rccm.202209-1653OC.

PMID: 36921087

 

The Promise and Reality of Public Engagement in the Governance of Human Genome Editing Research. 

Conley JM, Cadigan RJ, Davis AM, Juengst ET, Kuczynski K, Major R, Stancil H, Villa-Palomino J, Waltz M, Henderson GE.

Am J Bioeth. 2023 May 19:1-8. doi: 10.1080/15265161.2023.2207502. Online ahead of print.

PMID: 37204137

 

A living ex vivo platform for functional, personalized brain cancer diagnosis. 

Mann B, Zhang X, Bell N, Adefolaju A, Thang M, Dasari R, Kanchi K, Valdivia A, Yang Y, Buckley A, Lettry V, Quinsey C, Rauf Y, Kram D, Cassidy N, Vaziri C, Corcoran DL, Rego S, Jiang Y, Graves LM, Dunn D, Floyd S, Baldwin A, Hingtgen S, Satterlee AB.

Cell Rep Med. 2023 May 8:101042. doi: 10.1016/j.xcrm.2023.101042. Online ahead of print.

PMID: 37192626