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UNC Genetics PublicationsDepartment of Genetics faculty, postdocs, students and collaborators published 10 papers during September 11th – 24th, 2022.


Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses. 

Drewry DH, Potjewyd FM, Bayati A, Smith JL, Dickmander RJ, Howell S, Taft-Benz S, Min SM, Hossain MA, Heise M, McPherson PS, Moorman NJ, Axtman AD.

J Med Chem. 2022 Sep 16. doi: 10.1021/acs.jmedchem.2c00697. Online ahead of print.

PMID: 36111834


The association of epigenetic age acceleration and multimorbidity at age 90 in the Women’s Health Initiative. 

Jain P, Binder A, Chen B, Parada H, Gallo LC, Alcaraz J, Horvath S, Bhatti P, Whitsel EA, Jordahl K, Baccarelli AA, Hou L, Stewart JD, Li Y, LaMonte MJ, Manson JE, LaCroix AZ.

J Gerontol A Biol Sci Med Sci. 2022 Sep 15:glac190. doi: 10.1093/gerona/glac190. Online ahead of print.

PMID: 36107798


Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity. 

Mirlekar B, Wang Y, Li S, Zhou M, Entwistle S, De Buysscher T, Morrison A, Herrera G, Harris C, Vincent BG, Ting JP, Rashid N, Kim WY, Yeh JJ, Pylayeva-Gupta Y.

Cell Rep Med. 2022 Sep 3:100744. doi: 10.1016/j.xcrm.2022.100744. Online ahead of print.

PMID: 36099917


3D Chromatin Structure in Chondrocytes Identifies Putative Osteoarthritis Risk Genes. 

Thulson E, Davis ES, D’Costa S, Coryell PR, Kramer NE, Mohlke KL, Loeser RF, Diekman BO, Phanstiel DH.

Genetics. 2022 Sep 13:iyac141. doi: 10.1093/genetics/iyac141. Online ahead of print.

PMID: 36099032


Focus on your locus with a massively parallel reporter assay. 

McAfee JC, Bell JL, Krupa O, Matoba N, Stein JL, Won H.

J Neurodev Disord. 2022 Sep 9;14(1):50. doi: 10.1186/s11689-022-09461-x.

PMID: 36085003 Free PMC article. Review.


Disparities in Emergency Department Prioritization and Rooming of Patients with Similar Triage Acuity Score. 

Lin P, Argon NT, Cheng Q, Evans CS, Linthicum B, Liu Y, Mehrotra A, Patel MD, Ziya S.

Acad Emerg Med. 2022 Sep 14. doi: 10.1111/acem.14598. Online ahead of print.

PMID: 36104028


Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring. 

Schrott R, Modliszewski JL, Hawkey AB, Grenier C, Holloway Z, Evans J, Pippen E, Corcoran DL, Levin ED, Murphy SK.

Epigenetics Chromatin. 2022 Sep 10;15(1):33. doi: 10.1186/s13072-022-00466-3.

PMID: 36085240 Free PMC article.


Mediation analysis of multiple mediators with incomplete omics data. 

Kidd J, Raulerson CK, Mohlke KL, Lin DY.

Genet Epidemiol. 2022 Sep 20. doi: 10.1002/gepi.22504. Online ahead of print.

PMID: 36125445


Approaches to incorporate extracellular vesicles into exposure science, toxicology, and public health research. 

Carberry CK, Keshava D, Payton A, Smith GJ, Rager JE.

J Expo Sci Environ Epidemiol. 2022 Sep;32(5):647-659. doi: 10.1038/s41370-022-00417-w. Epub 2022 Feb 25.

PMID: 35217808 Free PMC article. Review.


RNA-based classification of homologous recombination deficiency in racially-diverse patients with breast cancer. 

Walens A, Van Alsten SC, Olsson LT, Smith MA, Lockhart A, Gao X, Hamilton AM, Kirk EL, Love MI, Gupta GP, Perou CM, Vaziri C, Hoadley KA, Troester MA.

Cancer Epidemiol Biomarkers Prev. 2022 Sep 21:EPI-22-0590. doi: 10.1158/1055-9965.EPI-22-0590. Online ahead of print.

PMID: 36129803