Use

DDAVP (desmopressin acetate) is a synthetic hormone used to increase the clotting factors in people with certain bleeding disorder including mild hemophilia A, type 1 von Willebrand disease, and some platelet dysfunction disorders.

Action

Temporarily improves factor 8 levels, von Willebrand factor levels and platelet function.

• Effect begins in 30 minutes, peaks in 90 minutes, and lasts approximately 12

Dosing

DDAVP Subcutaneous Injection (desmopressin acetate vial concentration 4mcg/ml)

• Dosage is determined by your weight in kilograms – 3 micrograms per
• DDAVP can be used for minor procedures or
• DDAVP is not intended for use with a major or life-threatening bleeding episode (ex: major surgery, bleed in spine, neck, or head, etc.)

Storage

Keep refrigerated and check the expiration date.

Side Effects

Side effects are temporary and occur more frequently when DDAVP is given intravenously.

Common side effects may include:

• Slight increase in blood pressure or pulse
• Headache
• Nausea
• Facial flushing
• Dizziness
• Urinary retention
• Low sodium levels (stomach cramps, muscle weakness, headache, nausea, or vomiting)

Precautions

To avoid low sodium levels, we recommend the following for 24 hours after DDAVP:

• NO more than 5 liters oral and IV fluid combined
• Avoid plain water and drink only enough to satisfy your thirst
  • Gatorade, Vitamin Water, are good alternatives
• Eat salty foods and snacks
• Avoid drinking caffeine or alcohol
• Avoid strenuous workouts or activities that will cause significant sweating
• Do not take antidiuretics or “fluid pills” – talk to your doctor or nurse