The Institute for Scientific Information at Clarivate uses bibliometric professionals and data scientists to identify influential researchers in their respective fields. This recognition extends to Bryan Roth and Xi-Ping Huang, acknowledged for ranking in the top 1% by citations for their field and publication year in the Web of Science™ citation index.
The Roth Lab delves deeply into the study of G-protein coupled receptors (GPCRs), emphasizing ligand-receptor interactions. Presently, the lab directs its attention to the serotonin and opioid receptor families and their accessory proteins. In the field of synthetic neurobiology, the lab takes an active lead, gaining acclaim for the invention of the widely embraced chemogenetic technology, DREADD (Designer Receptors Exclusively Activated by Designer Drug). This technology has earned worldwide recognition and actively finds application in numerous laboratories globally.
Shifting focus from receptors to pharmacological therapeutics, the Roth Lab drives initiatives in drug discovery. Bryan and Xi-Ping serve as the Director and Assistant Scientific Director of the National Institute of Mental Health’s Psychoactive Drug Screening Program (NIMH-PDSP). In their collaborative efforts, they encompass high throughput screening campaigns, lead compound characterization, and structure-activity relationship studies. Notably, Xi-Ping’s work spans GPCR structures, functional selectivity, and the design and optimization of probes. His research projects focused on Hydron-sensing GPCRs reported the first small molecule positive allosteric modulator (PAM) ogerin.
The recognition of Bryan Roth and Xi-Ping Huang as Globally Highly Cited Researchers underscores their impact on scientific knowledge, positioning them as contributors in their respective fields and advancing innovation and discovery.