Dr. Henrik Dohlman, Sanford Steelman Distinguished Professor and Chair of the Department of Pharmacology, was named the American Society for Pharmacology and Experimental Therapeutics Fellow (FASPET) of 2023 in recognition of his dedication to advance the field of Pharmacology.
The American Society for Pharmacology and Experimental Therapeutics (ASPET) consists of a group of interdisciplinary scientists engaged in basic and clinical pharmacological research. This collective effort aims to develop new therapeutics to address various diseases. Annually, ASPET announces its class of fellows to honor outstanding members. This year, Dr. Henrik Dohlman is acknowledged for his work in G protein signaling.
The Dohlman lab is committed to elucidating the mechanisms of cell desensitization, particularly in the context of G protein signaling. The lab’s research centers on G proteins, Regulators of G protein signaling (RGS) proteins, and G protein-coupled receptors (GPCRs), which play crucial roles in cellular signaling pathways and are significant targets for pharmaceuticals. Pioneering large-scale genomic and proteomic analyses in yeast, the lab identified essential proteins, including the first RGS protein that regulates G proteins by accelerating their GTPase activity. Additionally, the lab explores the role of enzymes in the post-translational modification of G proteins. They are currently working on characterizing G protein regulation by metabolites and chemical second messengers, unraveling the intricacies of signaling processes under diverse cellular conditions.
The recognition of Henrik as a 2023 FASPET underscores his significant contribution to understanding cellular signaling mechanisms in therapeutics development and the advancement of Pharmacology. Congratulations, Henrik!
