From Sanford
- Take US-1/US-15/US-501 North toward Pittsboro/Raleigh
- At the US-1 North US-15/US-501 North split, take US-15/US-501 North toward Pittsboro
- Enter the roundabout in downtown Pittsboro and take the 2nd exit onto US-15/US-501 North
- Continue to follow US-15/US-501 North for 15.5 miles until you reach the Chapel Hill city limits.
- Stay straight to continue on NC-86/South Columbia Street (DO NOT THE TAKE US-15/US-501 North EXIT TO THE RIGHT)
- Continue up the hill and turn right at the first traffic light onto Mason Farm Road
- Immeditely make the next right turn (about 100 feet up Mason Farm Road).
- The EPA Human Studies Facility is on your left as you approach the parking gate.
- Take a parking ticket (parking expenses are reimbursed).
- Make the first left turn and park in an available space.
- The entrance to the building is toward the rear of the parking lot and up the hill back toward Mason Farm Road.
