December 12, 2019
My long-term research goals are to understand mechanisms involved in coagulation and develop novel therapies that augment the body’s native clotting and subsequent healing processes. A primary research focus in my group is the development of platelet-mimetic materials that participate in the natural coagulation cascade to promote hemostasis and enhance healing outcomes.
December 12, 2019
I studied the epidemiology of sickle cell disease during my doctoral training and am currently an Assistant Professor in biomedical engineering. I am developing a wearable device to monitor hydration status in individuals with sickle cell disease, and a contact-free assay to evaluate stored red blood cell quality prior to transfusion. I have coauthored 3 manuscripts with Dr. Nigel Key, who also served on my dissertation committee. I have also been mentored by Dr. Enrico Novelli at the University of Pittsburgh, where I participated as a research scholar in the NHLBI-funded Intensive Training in Hematology program. For the past 4 years, I have served as an abstract reviewer for the Foundation for Sickle Cell Disease Research Symposium.
December 12, 2019
Assistant Professor, Research interests: I am interested in the interaction between endothelium and coagulation proteins as well as blood cells. I have recently presented data showing an increase of factor Xa generation on endothelium in the presence of emicizumab and factor IXa. I am active in investigating the mechanism of thrombosis and thrombotic microangiopathy in the use of emicizumab and have an interest in improving the treatment of breakthrough bleeding in patients on emicizumab. I am more generally interested in the development of systems that can shed light on the mechanisms and complications of emerging, non-factor therapies for hemophilia.
December 12, 2019
Research Interests My research interest focuses on the mechanisms of cancer-associated thrombosis and bleeding. My primary interest is mechanisms of pancreatic cancer-associated venous thrombosis because pancreatic cancer has one of the highest rates of venous thrombosis. I have found that tumor-derived tissue factor positive extracellular vesicles, neutrophils and neutrophil extracellular traps, and plasminogen activator inhibitor-1 independently contribute to venous thrombosis in mouse models of pancreatic cancer.
December 12, 2019
My research broadly involves blood transfusion efficacy and quality. I am particularly interested in the variables that impact red cell unit quality and its effects on chronic transfusion protocols. The aim of my current multi-center randomized clinical studies is to improve transfusion efficacy for adults with sickle cell disease.
December 9, 2019
My research interests include, identification of polysaccharide-based receptor; structure and specificity of a heparan sulfate-based herpes simplex virus 1 receptor; drug targeting; gene therapy.
December 5, 2019
I am the Director of the Francis Owen Blood Research Laboratory (FOBRL), the mission of which is to reduce human and animal suffering from bleeding, thrombosis and atherosclerosis by the study of unique, genetically-determined animal models of these diseases. The FOBRL was established in 1960 by Dr. Kenneth M. Brinkhous and has provided work and study opportunities for many undergraduate, M.D., D.V.M. and Ph.D. students, post-doctoral students, and faculty at UNC and from several institutions worldwide.
December 5, 2019
Research Interests My research focus is clinical research in the field of therapeutic apheresis, specifically thrombotic thrombocytopenic purpura (TTP). Although my research started quite small, using data and samples from UNC, it has grown to be incredibly collaborative through a number of professional organizations and relationships throughout the country and internationally. I have evolved my …
December 4, 2019
My lab develops microfluidic models of the blood and lymphatic vasculature for basic science and translational purposes. Specific projects relevant to the Blood Research Center are: 1) Understanding the role of Notch receptor signaling in vascular endothelial adherens junction assembly and stability; 2) A nascent collaboration with Dr. Prabir Roy-Chaudhury at the UNC Kidney center to screen patient plasma in microfluidic models of the vasculature to predict risk of cardiovascular complications in kidney disease.
December 2, 2019
As individuals with sickle cell disease (SCD) are living longer, there is a growing adolescent and young adult population with unique manifestations of SCD that are poorly understand. My research interests are broadly in understanding clinical outcomes in SCD management, characterizing individuals at greater risk for complications and in improving guideline-based care of those with SCD, especially in the diagnosis and management of iron overload. I am joining the non-malignant hematology faculty at UNC and am interested in pursing research in non-malignant hematology. As a member of the BRC, I will have the support and opportunity to continue my research pursuits.