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Click here to read the February 2023 Newsletter

Antoniak Lab published a study investigating the role of thrombin-PAR1 signaling in chemotherapy induced heart failure. UNC Blood Research Center researchers Drs Grover, Bharathi, Mackman and Antoniak in collaboration with Drs. Posma, Griffin and Palumbo published in Blood Advances “Thrombin mediated activation of PAR1 enhances doxorubicin induced cardiac injury in mice”. Dr. Antoniak was the …

The contact pathway of coagulation has been implicated in the pathogenesis of venous thrombosis. Relatively little, however, is known about the the role of C1 inhibitor, the major negative regulator of this pathway, in venous thrombosis. Work led by Steven Grover and Nigel Mackman revealed that C1 inhibitor deficiency, resulting in the genetic disorder Hereditary …

Work led by postdoctoral fellow Jun Wan, PhD under the supervision of Steven Grover, PhD and Nigel Mackman, PhD establishing a novel mouse whole blood thrombin generation assay has been published in the Journal Blood Advances. In this work the authors found that the novel mouse whole blood assay provided increased sensitivity to amplifying coagulation …

Congratulations to Research Assistant Professor Steven Grover, PhD who received a 2023 UNC Junior Faculty Development Award to support his work studying “The role of endogenous C1 inhibitor as a negative regulator of coagulation in the general population”. This highly competitive award is supported by the UNC Office of the Provost with funds provided by IBM and R.J. …

Rafal Pawlinski, PhD and Jian Liu, PhD were published in the Proceedings of the National Academy of Sciences (PNAS) Journal for their paper, “Using heparan sulfate octadecasaccharide (18-mer) as a multi-target agent to protect against sepsis”. Click here to read the paper.

Stephanie Reitsma’s proposal titled “Phenotypic modifiers in people with low factor XI” was awarded the American Heart Association (AHA) postdoctoral fellowship award. She will use a multidisciplinary approach to determine bleeding risk determinants in FXI deficiency. This project will be guided by her co-mentors Drs. Alisa Wolberg and Karin Leiderman for the duration of 2 …

Yaqiu Sang was awarded the Postdoctoral Fellowship from American Heart Association (Duration: 2023/1/1-2024/12/31) last December. The title of her awarded project is “Platelet factor XIII regulation and role in pulmonary embolism”. Under the guidance of Dr. Wolberg and Dr. Bergmeier, she will identify the mechanisms regulating platelet FXIII biology and the relative contributions of plasma …

Abigail Ballard, a BCBP PhD candidate in Wolfgang Bergmeier’s lab, was awarded a Ruth L. Kirschstein NRSA Predoctoral Fellowship (F31) from the National Heart, Lung, and Blood Institute. The proposal titled “The Role of the Small GTPase Rap1 in Platelet Coagulation Interplay” will investigate the regulation platelet procoagulant response by Rap1 and Rho family small …

photo of matthew karafin, smiling in a suit

Matthew S. Karafin, MD Msc Published in Transfusion, “Hypoxic storage of donor red cells preserves deformability after exposure to plasma from adults with sickle cell disease” Dr. Matthew Karafin was the lead author on a multi-institutional investigation into the role of red cell storage conditions and patient clinical state on donor red cell deformability. The …

Dr. Yohei Hisada was appointed as a Co-chair of the International Society on Thrombosis and Haemostasis (ISTH) Scientific and Standardization committee (SSC) on Vascular Biology. He will serve as a co-chair for 4 years. The detail about the ISTH SSC on Vascular Biology can be found here.

Brandi Reeves, MD was awarded a Core Facilities voucher to characterize neurobehavioral changes in a mouse model of polycythemia vera. Neurobehavioral complaints are common in patients with polycythemia vera (PV), with 75% of patients reporting symptoms. Fatigue, inactivity, and concentration difficulties are the most common and severe symptoms experienced by PV patients and result in …

Category: News

BRC Newsletter – February 2023

Silvio Antoniak, PhD and BRC Colleagues Published in Blood

Steven Grover, PhD and BRC Colleagues Published in Blood

Jun Wan, PhD Published in Blood Advances

Steven Grover, PhD Receives 2023 UNC Junior Faculty Development Award

Rafal Pawlinski, PhD and Jian Liu, PhD Published in PNAS

Stephanie Reitsma, PhD Awarded American Heart Association Award

Yaqiu Sang, PhD Awarded the Postdoctoral Fellowship from American Heart Association

Abigail Ballard Awarded an F31 From the National Heart Lung and Blood Institute

Matthew S. Karafin, MD Msc Published in Transfusion

Yohei Hisada, PhD Appointed as Co-Chair of the ISTH SCC

Brandi Reeves, MD Awarded a Core Facilities Voucher