July 15, 2021
A Multi-center Prospective Cohort Study in Adults with Sickle Cell Disease suggests that infusion centers give faster, more patient-centered symptom relief for people with sickle cell disease. Efforts ongoing to apply these lessons locally! 269 people with Sickle cell disease, followed at 4 US sites, were evaluated for treatment outcomes after being seen for management …
June 17, 2021
Congratulations Tina Abrams for being honored twice at the Department of Pediatrics Award Day. Tina was honored for her stellar research presentation at the Day of Scholarship in May. She earned the award for Best Basic Science Presentation as well Best Overall Research. Tina is currently part of Dr. Rafal Pawlinski’s Lab in the UNC …
April 29, 2021
We might never know the answer to these specific questions, but we should continue to document realworld findings, particularly regarding the risks and benefits of voxelotor to end-organ function. Building on preclinical models,7 preliminary studies showing preserved or lowered cerebral blood flow,8 together with the results of this study1 and ongoing studies, such as HOPE …
April 16, 2021
UNC is now a fully active clinical site for the ACTIV-4c Post-Hospital Thrombosis Prevention Study, led at UNC-Chapel Hill by Raj Kasthuri, MBBS, Professor of Medicine. This protocol is part of the larger ACTIV (Accelerating COVID-Therapeutic Interventions and Vaccine) study. Raj Kasthuri, MBBS UNC is now a fully active clinical site for the ACTIV-4c …
April 8, 2021
Michael Henderson, PhD, Key lab of the Blood Research Center has first author publication: Abstract Acetaminophen (APAP)-induced liver injury is associated with activation of coagulation and fibrinolysis. In mice, both tissue factor-dependent thrombin generation and plasmin activity have been shown to promote liver injury after APAP overdose. However, the contribution of the contact and intrinsic …
April 7, 2021
Two members of the UNC Blood Research Center, Rafal Pawlinski PhD and Nigel Key MD, both Professors in the Department of Medicine, Division of Hematology, have been awarded a $2.8 million, 4-year RO1 grant from the NIH-NHLBI to investigate the mechanism of venous thromboembolism (VTE) in sickle cell disease (SCD). Dr. Rafal Pawlinski and Dr. …
March 9, 2021
UNC Blood Research Center to sponsor HTRS Travel Awards! HTRS provides grants to support up to $1,500 in travel and lodging, plus complimentary meeting registration fees for young investigators who submit the highest scoring abstracts to be displayed as posters at HTRS Scientific Symposia. HTRS 2021 Scientific Symposium – Virtual Event March 8 @ 12:30 …
March 5, 2021
Steven Grover, PhD awarded a CSL Behring Prof Heimburger Award Congratulations to Steven Grover, PhD, a postdoctoral fellow in the laboratory of Nigel Mackman, PhD, who has been awarded a 2021 Prof Heimburger Award from CSL Behring. This award will provide research support for his project “Evaluating the anticoagulant activity of C1 esterase inhibitor in …
February 21, 2021
Congratulations to Steven Grover, PhD, a postdoctoral fellow in the laboratory of Nigel Mackman, PhD, who has been awarded a Journal of Thrombosis and Haemostasis Editors Award for his recent publication “Model‐dependent contributions of FXII and FXI to venous thrombosis in mice”. The award consists of a certificate, to be presented at the JTH Editors Luncheon held at the ISTH Congress, …
January 21, 2021
Dr. Alisa Wolberg, Scientific Co-Chair of the American Society of Hematology 2020 meeting, was interviewed about abstracts selected for the Best of ASH for the podcast “Blood & Cancer”. The episode is available at this link, and can be accessed via any platform you use to listen to podcasts. Alisa Wolberg, PhD
January 19, 2021
A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells. Authors: Giang N. Nguyen, John K. Everett, Samita Kafle, Aoife M. Roche, Hayley E. Raymond, Jacob Leiby, Christian Wood, Charles-Antoine Assenmacher, Elizabeth P. Merricks, C. Tyler Long, Haig H. Kazazian, Timothy C. Nichols, Frederic D. Bushman …
January 19, 2021
Congratulations to Erica Sparkenbaugh, Assistant Professor in the UNC Department of Medicine Hematology, and member of the Blood Research Center. She has been awarded a five year, $2 million R01 grant from NIH-NHLBI beginning January 2021. The goal of this project is to evaluate whether activation of beneficial PAR1 signaling can attenuate the chronic pro-coagulant …