Michael Kasten, PhD

Assistant Professor

Specialty:

Processing auditory information and how degradation of the auditory signal with age or noise exposure affects these cells and circuits.

Education:

  • BSE, Biomedical Engineering, University of Iowa, Iowa City, IA
  • PhD, Neuroscience, Baylor College of Medicine, Houston, TX

Professional Experience:

  • Assistant Professor, University of North Carolina at Chapel Hill, Chapel Hill, NC
  • Postdoc, University of North Carolina at Chapel Hill, Chapel Hill, NC
  • Research Scientist, Rehabilitation Medicine, University of Washington, Seattle, WA
  • Postdoc, Neurology, BIDMC/Harvard Medical School, Boston, MA
  • Postdoc, Neuroscience, Baylor College of Medicine, Houston, TX
  • Graduate Student Instructor, Cellular Neuroscience, Baylor College of Med, Houston, TX

Honors:

  • 1997-2000 NIH NIDA Individual Predoctoral Fellowship – Ruth L. Kirschstein NRSA

Recent Publications:

  • Manis P.B., Kasten M.R., Xie R. (2019) Classification of Neurons in the Adult Mouse Cochlear Nucleus: Linear Discriminant Analysis. bioRxiv 594713 [Preprint]. April 2, 2019 available from https://doi.org/10.1101/59471.
  • Xie R, Ropp TF, Kasten MR, Manis PB. The Oxford Handbook of the Auditory Brainstem. Kandler K, editor. London, U.K.: Oxford University Press; 2018. Age-Related and Noise-Induced Hearing Loss: Central Consequences in the Ventral Cochlear Nucleus.
  • Xhang X., Sullivan C. S., Kratz M. B., Kasten M. R., Maness P. F., Manis P. B. (2017) NCAM Regulates Inhibition and Excitability in Layer 2/3 Pyramidal Cells of Anterior Cingulate Cortex. Front Neural Circ10.3389/fncir.2017.00019.
  • Kasten M. R.and Anderson M. P. (2015). Self-regulation of adult thalamocortical neurons. Neurophysiol. 10:1152/jn.00800.2014.
  • Mondello S. E., Kasten M. R., Horner P. J., and Moritz C. T. (2014). Therapeutic intraspinal stimulation to generate activity and promote long-term recovery. Front Neurosci. 8:21.
  • Kasten M. R., Sunshine M. D., Secrist E. S., Horner P. J., and Moritz C. T. (2013). Therapeutic intraspinal microstimulation improves forelimb function after cervical contusion injury. J Neural Eng. 10:044001.
  • Sunshine M. D., Cho F. S., Lockwood D. R., Fechko A. S., Kasten M. R., Moritz C. T. (2013). Cervical intraspinal microstimulation evokes robust forelimb movements before and after injury. J Neural Eng. 10:03600.
  • Kasten M. R., Connelly T., Fan Y., Schulz P. E. (2012). A form of synaptically-induced metabotropic glutamate receptor-dependent long-term depression that does not require postsynaptic calcium. Neuroscience Lett. 511:12-17.
  • Smith S. E., Xu L., Kasten M. R., Anderson M. P. (2012). Mutant LGI1 inhibits seizure-induced trafficking of Kv4.2 potassium channels. J. Neurochem. 74: 2154-2166.
  • Kasten M. R., Fan Y., and Schulz P. E. (2007). Activation of silent synapses with sustained but not decremental long-term potentiation.  Neuroscience Lett. 417:84-89.
  • Kasten M. R., Rudy B., Anderson, M. P. (2007). Differential regulation of action potential firing in adult murine thalamocortical neurons by Kv3.2, Kv1, and SK potassium and N-type calcium channels. J Physiol 584:565-582.