Department of Genetics Publications for July 21st – August 3rd, 2024

Department of Genetics faculty, postdocs, students and collaborators published 13 papers during July 21st – August 3rd, 2024.

 

Gene expression and splicing QTL analysis of blood cells in African American participants from the Jackson Heart Study. 

Wen J, Sun Q, Huang L, Zhou L, Doyle MF, Ekunwe L, Durda P, Olson NC, Reiner AP, Li Y, Raffield LM.

Genetics. 2024 Jul 26:iyae098. doi: 10.1093/genetics/iyae098. Online ahead of print.

PMID: 39056362

 

Schizophrenia genomics: genetic complexity and functional insights. 

Sullivan PF, Yao S, Hjerling-Leffler J.

Nat Rev Neurosci. 2024 Jul 19. doi: 10.1038/s41583-024-00837-7. Online ahead of print.

PMID: 39030273 Review.

 

More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. 

Ong HW, Yang X, Smith JL, Dickmander RJ, Brown JW, Havener TM, Taft-Benz S, Howell S, Sanders MK, Capener JL, Couñago RM, Chang E, Krämer A, Moorman NJ, Heise M, Axtman AD, Drewry DH, Willson TM.

J Med Chem. 2024 Jul 25;67(14):12261-12313. doi: 10.1021/acs.jmedchem.4c00962. Epub 2024 Jul 3.

PMID: 38959455

 

DISPARITIES IN ACCESS TO REPRODUCTIVE GENETIC SERVICES ASSOCIATED WITH GEOGRAPHIC LOCATION OF RESIDENCE AND MATERNAL ETHNICITY. 

Talati ASHAN, Mallampati DIVYAP, Hardisty EMILYE, Gilmore KELLYL, Vora NEETAL.

Genet Med. 2024 Jul 20:101221. doi: 10.1016/j.gim.2024.101221. Online ahead of print.

PMID: 39045791

 

Presynaptic sensor and silencer of peptidergic transmission reveal neuropeptides as primary transmitters in pontine fear circuit. 

Kim DI, Park S, Park S, Ye M, Chen JY, Kang SJ, Jhang J, Hunker AC, Zweifel LS, Caron KM, Vaughan JM, Saghatelian A, Palmiter RD, Han S.

Cell. 2024 Jul 17:S0092-8674(24)00709-8. doi: 10.1016/j.cell.2024.06.035. Online ahead of print.

PMID: 39043179

 

Redesigning the Drosophila histone gene cluster: An improved genetic platform for spatiotemporal manipulation of histone function. 

Crain AT, Nevil M, Leatham-Jensen MP, Reeves KB, Matera AG, McKay DJ, Duronio RJ.

Genetics. 2024 Jul 22:iyae117. doi: 10.1093/genetics/iyae117. Online ahead of print.

PMID: 39039029

 

Governing with public engagement: an anticipatory approach to human genome editing. 

Barlevy D, Juengst E, Kahn J, Moreno J, Lambert L, Charo A, Chneiweiss H, Farooque M, Guston DH, Hyun I, Knoepfler PS, Selin C, Wilbanks R, Zaghlula M, Scott CT.

Sci Public Policy. 2024 Mar 25;51(4):680-691. doi: 10.1093/scipol/scae010. eCollection 2024 Aug.

PMID: 39035203 Free PMC article.

 

Additional impact of genetic ancestry over race/ethnicity to prevalence of KRAS mutations and allele-specific subtypes in non-small cell lung cancer. 

Wang X, Hou K, Ricciuti B, Alessi JV, Li X, Pecci F, Dey R, Luo J, Awad MM, Gusev A, Lin X, Johnson BE, Christiani DC.

HGG Adv. 2024 Jul 18;5(3):100320. doi: 10.1016/j.xhgg.2024.100320. Epub 2024 Jun 19.

PMID: 38902927

 

DNA methylation near MAD1L1, KDM2B, and SOCS3 mediates the effect of socioeconomic status on elevated body mass index in African American adults. 

Glover L, Lilly AG, Justice AE, Howard AG, Staley BS, Wang Y, Kamens HM, Ferrier K, Bressler J, Loehr L, Raffield LM, Sims M, North KE, Fernández-Rhodes L.

Hum Mol Genet. 2024 Jul 31:ddae112. doi: 10.1093/hmg/ddae112. Online ahead of print.

PMID: 39079086

 

SRPK3 Is Essential for Cognitive and Ocular Development in Humans and Zebrafish, Explaining X-Linked Intellectual Disability. 

Roychaudhury A, Lee YR, Choi TI, Thomas MG, Khan TN, Yousaf H, Skinner C, Maconachie G, Crosier M, Horak H, Constantinescu CS, Kim TY, Lee KH, Kyung JJ, Wang T, Ku B, Chodirker BN, Hammer MF, Gottlob I, Norton WHJ, Gerlai R, Kim HG, Graziano C, Pippucci T, Iovino E, Montanari F, Severi G, Toro C, Boerkoel CF, Cha HS, Choi CY, Kim S, Yoon JH, Gilmore K, Vora NL, Davis EE, Chudley AE, Schwartz CE, Kim CH.

Ann Neurol. 2024 Jul 29. doi: 10.1002/ana.27037. Online ahead of print.

PMID: 39073169

 

Large changes in detected selection signatures after a selection limit in mice bred for voluntary wheel-running behavior. 

Hillis DA, Yadgary L, Weinstock GM, de Villena FP, Pomp D, Garland T Jr.

PLoS One. 2024 Aug 1;19(8):e0306397. doi: 10.1371/journal.pone.0306397. eCollection 2024.

PMID: 39088483 Free PMC article.

 

Examining the impact of Native American myopathy on the quality of life and healthcare accessibility of patients and caregivers. 

Wang MG, Lancaster K, Powell CM.

Am J Med Genet A. 2024 Jul 29:e63829. doi: 10.1002/ajmg.a.63829. Online ahead of print.

PMID: 39073004

 

Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohorts. 

Katrinli S, Wani AH, Maihofer AX, Ratanatharathorn A, Daskalakis NP, Montalvo-Ortiz J, Núñez-Ríos DL, Zannas AS, Zhao X, Aiello AE, Ashley-Koch AE, Avetyan D, Baker DG, Beckham JC, Boks MP, Brick LA, Bromet E, Champagne FA, Chen CY, Dalvie S, Dennis MF, Fatumo S, Fortier C, Galea S, Garrett ME, Geuze E, Grant G, Michael A Hauser, Hayes JP, Hemmings SM, Huber BR, Jajoo A, Jansen S, Kessler RC, Kimbrel NA, King AP, Kleinman JE, Koen N, Koenen KC, Kuan PF, Liberzon I, Linnstaedt SD, Lori A, Luft BJ, Luykx JJ, Marx CE, McLean SA, Mehta D, Milberg W, Miller MW, Mufford MS, Musanabaganwa C, Mutabaruka J, Mutesa L, Nemeroff CB, Nugent NR, Orcutt HK, Qin XJ, Rauch SAM, Ressler KJ, Risbrough VB, Rutembesa E, Rutten BPF, Seedat S, Stein DJ, Stein MB, Toikumo S, Ursano RJ, Uwineza A, Verfaellie MH, Vermetten E, Vinkers CH, Ware EB, Wildman DE, Wolf EJ, Young RM, Zhao Y, van den Heuvel LL; PGC-PTSD Epigenetics Workgroup, PsychENCODE PTSD Brainomics Project, Traumatic Stress Brain Research Group; Uddin M, Nievergelt CM, Smith AK, Logue MW.

medRxiv [Preprint]. 2024 Jul 15:2024.07.15.24310422. doi: 10.1101/2024.07.15.24310422.

PMID: 39072012 Free PMC article. Preprint.