Department of Genetics faculty, postdocs, students and staff published nine papers during July 26 – August 8, 2020.
| Immunopathogenesis of alphaviruses.
Baxter VK, Heise MT. Adv Virus Res. 2020;107:315-382. doi: 10.1016/bs.aivir.2020.06.002. Epub 2020 Jul 8. PMID: 32711733 |
| Otitis media susceptibility and shifts in the head and neck microbiome due to SPINK5 variants.
Frank DN, Giese APJ, Hafren L, Bootpetch TC, Yarza TKL, Steritz MJ, Pedro M, Labra PJ, Daly KA, Tantoco MLC, Szeremeta W, Reyes-Quintos MRT, Ahankoob N, Llanes EGDV, Pine HS, Yousaf S, Ir D, Einarsdottir E, de la Cruz RAR, Lee NR, Nonato RMA, Robertson CE, Ong KMC, Magno JPM, Chiong ANE, Espiritu-Chiong MC, San Agustin ML, Cruz TLG, Abes GT, Bamshad MJ, Cutiongco-de la Paz EM, Kere J, Nickerson DA, Mohlke KL, Riazuddin S, Chan A, Mattila PS, Leal SM, Ryan AF, Ahmed ZM, Chonmaitree T, Sale MM, Chiong CM, Santos-Cortez RLP. J Med Genet. 2020 Jul 24:jmedgenet-2020-106844. doi: 10.1136/jmedgenet-2020-106844. Online ahead of print. PMID: 32709676 |
| New insights into immunomodulation via overexpressing lipoic acid synthase as a therapeutic potential to reduce atherosclerosis.
Tian S, Nakamura J, Hiller S, Simington S, Holley DW, Mota R, Willis MS, Bultman SJ, Luft JC, DeSimone JM, Jia Z, Maeda N, Yi X. Vascul Pharmacol. 2020 Aug 1:106777. doi: 10.1016/j.vph.2020.106777. Online ahead of print. PMID: 32750408 |
| Common genetic risk variants identified in the SPARK cohort support DDHD2 as a candidate risk gene for autism.
Matoba N, Liang D, Sun H, Aygün N, McAfee JC, Davis JE, Raffield LM, Qian H, Piven J, Li Y, Kosuri S, Won H, Stein JL. Transl Psychiatry. 2020 Aug 3;10(1):265. doi: 10.1038/s41398-020-00953-9. PMID: 32747698 |
| Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer.
Crosby EJ, Acharya CR, Haddad AF, Rabiola CA, Lei G, Wei JP, Yang XY, Wang T, Liu CX, Wagner KU, Muller WJ, Chodosh LA, Broadwater G, Hyslop T, Shepherd JH, Hollern DP, He X, Perou CM, Chai S, Ashby BK, Vincent BG, Snyder JC, Force J, Morse MA, Lyerly HK, Hartman ZC. Clin Cancer Res. 2020 Jul 30. doi: 10.1158/1078-0432.CCR-20-0389. Online ahead of print. PMID: 32732224 |
| IL-6 Response to Psychosocial Stress Predicts 12-month Changes in Cardiometabolic Biomarkers in Perimenopausal Women.
Zannas AS, Gordon JL, Hinderliter AL, Girdler SS, Rubinow DR. J Clin Endocrinol Metab. 2020 Jul 24:dgaa476. doi: 10.1210/clinem/dgaa476. Online ahead of print. PMID: 32706883 |
| ExploreModelMatrix: Interactive exploration for improved understanding of design matrices and linear models in R.
Soneson C, Marini F, Geier F, Love MI, Stadler MB. F1000Res. 2020 Jun 4;9:512. doi: 10.12688/f1000research.24187.1. eCollection 2020. PMID: 32704355 |
| Interpretable Clinical Genomics with a Likelihood Ratio Paradigm.
Robinson PN, Ravanmehr V, Jacobsen JOB, Danis D, Zhang XA, Carmody LC, Gargano MA, Thaxton CL; UNC Biocuration Core, Karlebach G, Reese J, Holtgrewe M, Köhler S, McMurry JA, Haendel MA, Smedley D. Am J Hum Genet. 2020 Jul 29:S0002-9297(20)30230-5. doi: 10.1016/j.ajhg.2020.06.021. Online ahead of print. PMID: 32755546 |
| Discrete Adaptive Responses to MEK Inhibitor in Subpopulations of Triple-Negative Breast Cancer.
Goulet DR, Foster JP, Zawistowski JS, Bevill SM, Noel MP, Olivares-Quintero JF, Sciaky N, Singh D, Santos C, Pattenden SG, Davis IJ, Johnson GL. Mol Cancer Res. 2020 Aug 4:molcanres.1011.2019. doi: 10.1158/1541-7786.MCR-19-1011. Online ahead of print. PMID: 32753473 |