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UNC Genetics PublicationsDepartment of Genetics faculty, postdocs, students and collaborators published 10 papers during September 25th – October 8th, 2022.


Cell-Specific Actions of the Prostaglandin E-Prostanoid Receptor 4 Attenuating Hypertension: A Dominant Role for Kidney Epithelial Cells Compared With Macrophages. 

Yang T, Song C, Ralph DL, Andrews P, Sparks MA, Koller BH, McDonough AA, Coffman TM.

J Am Heart Assoc. 2022 Sep 29:e026581. doi: 10.1161/JAHA.122.026581. Online ahead of print.

PMID: 36172956


Using neuroimaging genomics to investigate the evolution of human brain structure. 

Alagöz G, Molz B, Eising E, Schijven D, Francks C, Stein JL, Fisher SE.

Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2200638119. doi: 10.1073/pnas.2200638119. Epub 2022 Sep 26.

PMID: 36161899


The molecular architecture of cell cycle arrest. 

Stallaert W, Taylor SR, Kedziora KM, Taylor CD, Sobon HK, Young CL, Limas JC, Varblow Holloway J, Johnson MS, Cook JG, Purvis JE.

Mol Syst Biol. 2022 Sep;18(9):e11087. doi: 10.15252/msb.202211087.

PMID: 36161508


Viral protease cleavage of MAVS in genetically modified mice with hepatitis A virus infection. 

Sun L, Feng H, Misumi I, Shirasaki T, Hensley L, González-López O, Shiota I, Chou WC, Ting JP, Cullen JM, Cowley DO, Whitmire JK, Lemon SM.

J Hepatol. 2022 Sep 21:S0168-8278(22)03120-8. doi: 10.1016/j.jhep.2022.09.013. Online ahead of print.

PMID: 36152761


Opportunistic binding of EcR to open chromatin drives tissue-specific developmental responses. 

Uyehara CM, Leatham-Jensen M, McKay DJ.

Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2208935119. doi: 10.1073/pnas.2208935119. Epub 2022 Sep 26.

PMID: 36161884


The convergence of tumor suppressors on interferon pathway in kidney cancer and its therapeutic implication. 

Langbein LE, Hajjar RE, Kim WY, Yang H.

Am J Physiol Cell Physiol. 2022 Sep 26. doi: 10.1152/ajpcell.00255.2022. Online ahead of print.

PMID: 36154696 Review.


A multi-omics longitudinal study of the murine retinal response to chronic low-dose irradiation and simulated microgravity. 

Kothiyal P, Eley G, Ilangovan H, Hoadley KA, Elgart SR, Mao XW, Eslami P.

Sci Rep. 2022 Oct 7;12(1):16825. doi: 10.1038/s41598-022-19360-9.

PMID: 36207342


STING-induced regulatory B cells compromise NK function in cancer immunity. 

Li S, Mirlekar B, Johnson BM, Brickey WJ, Wrobel JA, Yang N, Song D, Entwistle S, Tan X, Deng M, Cui Y, Li W, Vincent BG, Gale M Jr, Pylayeva-Gupta Y, Ting JP.

Nature. 2022 Oct 5. doi: 10.1038/s41586-022-05254-3. Online ahead of print.

PMID: 36198789


MagicalRsq: Machine-learning-based genotype imputation quality calibration. 

Sun Q, Yang Y, Rosen JD, Jiang MZ, Chen J, Liu W, Wen J, Raffield LM, Pace RG, Zhou YH, Wright FA, Blackman SM, Bamshad MJ, Gibson RL, Cutting GR, Knowles MR, Schrider DR, Fuchsberger C, Li Y.

Am J Hum Genet. 2022 Sep 26:S0002-9297(22)00412-8. doi: 10.1016/j.ajhg.2022.09.009. Online ahead of print.

PMID: 36198314


Short-term transcriptomic changes in the mouse neural tube induced by an acute alcohol exposure. 

Boschen KE, Steensen MC, Simon JM, Parnell SE.

Alcohol. 2022 Oct 3:S0741-8329(22)00088-X. doi: 10.1016/j.alcohol.2022.09.001. Online ahead of print.

PMID: 36202274