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Enriching lives by delivering next generation gene sequencing and data analysis

Corbin Jones

On behalf of the Office of the Vice Chancellor for Research, the School of Medicine, and the University of North Carolina; welcome to the High Throughput Sequencing Facility (HTSF) web site. The HTSF is now part of the Integrated Genomics Cores (IGC) which also includes Mammalian Genotyping Core (MGC) and the Functional Genomics Microarray Core. Just prior to the COVID shut down, HTSF brought on a new director of the IGC: Greg Bowen.We are pleased to have the opportunity to collaborate with you and support your research needs. The team is committed to providing the highest quality genomics and sequencing solutions, tailored to provide you the data you need to succeed, as cost effectively as possible. The HTSF have a long history in supporting research and scientific breakthroughs, and in helping understand a wide range of diseases and pathogens. We work with numerous vendors as beta testing sites for new services. Our R&D group can apply existing techniques in novel manners or help trouble shoot assays for you.
– Corbin Jones


Greg Bowen

I am still learning but I am thrilled to be a member of this extraordinary group of scientists and to play a role in supporting so many vital research projects, both here at UNC and with our many external customers and collaborators. This new HTSF website is one of many ongoing initiatives to continuously improve the services and the quality we provide. With an eye on the future and a focus on the present, we continue to offer both tried and true and new, next generation sequencing technology solutions. I look forward to working with you and hope the IGC’s and HTSF can become you long term partner and collaborator!
– Greg Bowen

History and Mission

The HTSF was established in 2008 with funds from the University Cancer Research Fund (UCRF) and the Lineberger Comprehensive Cancer Center (LCCC) and is managed by the UNC School of Medicine.

Our primary goal is to apply the tools of high throughput sequencing technology and experience to enrich medicine and basic biological research at The University of North Carolina. High-throughput sequencing is an extremely fast developing technology that is used to extract genetic and genomic data from a broad spectrum of biological materials. This information is not only be used to help identify the causes of complex diseases such as cancer, diabetes and cardiovascular disease and demonstrate the underlying bases for multiple types of infectious diseases.  It can be also used to analyze the complexities of diverse biological systems. Our goal is to support UNC researchers, students, and their collaborators in their work with our state-of-the-art technology to make medical and scientific breakthroughs happen. HTSF applies these tools to provide unique data and insights and solve problems for Government, industry, and academic partners throughout the world.

We support all commercially available high throughput sequencing platforms and regularly work with researchers to develop and implement novel cutting edge applications with these platforms. We frequently work directly with the developers of new systems as an early access customer to give them useful feedback and to give our researchers the earliest possible access to novel new technologies.

See the overview of the capabilities of the HTSF, HTSF Capabilities under Forms and Docs, white papers.