Director: Scott H. Donaldson, MD

MISSION

The development and validation of biomarkers that reflect different aspects of cystic fibrosis are of paramount importance to continued efforts to understand disease biology and the development of new therapeutics. Further, translation of basic research ideas into clinical studies that test their validity and clinical utility is of paramount importance to scientific advances in CF. The CF Clinical Translation Core was established to facilitate these goals.

19F-MRI

Mucociliary Clearance Imaging, via gamma scintigraphy

 

SERVICES

  • Biospecimen collection and repository
    • Cystic fibrosis (and disease control) sputum samples
    • Exhaled breath condensate
    • Excess clinical samples from bronchoscopy
    • Nasal epithelial samples
    • Rectal biopsy samples
  • Development of Novel Lung Imaging Outcomes
    • Mucociliary clearance, via gamma Scintigraphy
    • Lung ventilation imaging, via 19F-MRI
  • Regulatory and Biostatistics
    • Consultative advice for clinical study design
    • Guidance through required regulatory step before study initiation
    • Design of databases
    • Statistical analysis plans, power calculations, and data analysis

PERSONNEL

  • Scott H. Donaldson, MD – (Pulmonary, Core Director)
  • William Bennett, PhD (Mucociliary Clearance)
  • Yueh Lee, MD, PhD (Radiology)
  • Jennifer Goralski, MD (Pulmonary)
  • Agathe Ceppe (Biostatistics)
  • Evan Dellon, MD (Gastroenterology)
  • Margaret Powell (Research Assistant)

Support: Work in this core is funded by the NIH/NIDDK (Grant # P30 DK065988)

Contact Information

Scott H. Donaldson, MD
Professor of Medicine
2204 Marsico Hall, CB#7248
The University of North Carolina at Chapel Hill
Chapel Hill, NC 27599
Phone: 984-974-9198
Fax: 984-974-2968