Specialty Areas:
Lung Inflammation, Macrophage Biology, Inhalation Toxicology, Hepatotoxicity
Education:
DVM, College of Veterinary and Animal Sciences – Palampur, India (2001)
MVSc, Veterinary Biochemistry and Biotechnology, College of Veterinary Sciences, Pantnager, India (2003)
Dual-PhD, Genetics and Integrative Toxicology, Michigan State University (2009)
Selected Bibliography:
- Bayless R, Saini Y. Optimizing Neutrophil Recruitment to Tackle Bacterial Infections? Am J Respir Cell Mol Biol. 2025 Jan 21. doi: 10.1165/rcmb.2024-0575ED. Epub ahead of print. PMID: 39836037.
- Choudhary I, Lamichhane R, Singamsetty D, Vo T, Brombacher F, Patial S, Saini Y. Cell-Specific Contribution of IL-4 Receptor α Signaling Shapes the Overall Manifestation of Allergic Airway Disease. Am J Respir Cell Mol Biol. 2024 Dec;71(6):702-717. doi: 10.1165/rcmb.2024-0208OC. PMID: 39254378; PMCID: PMC11622633.
- Mao Y, Suryawanshi A, Patial S, Saini Y. Airspaces-derived exosomes contain disease-relevant protein signatures in a mouse model of cystic fibrosis (CF)-like mucoinflammatory lung disease. Front Pharmacol. 2024 Sep 25;15:1460692. doi: 10.3389/fphar.2024.1460692. PMID: 39386033; PMCID: PMC11461968.
- Paudel S, Kumar R, Rogers KA, Saini Y, Patial S, Kulkarni R. The NLRP3 Inflammasome Is Dispensable in Methicillin-Resistant Staphylococcus aureus Urinary Tract Infection. Pathogens. 2024 Jan 25;13(2):106. doi: 10.3390/pathogens13020106. PMID: 38392844; PMCID: PMC10893321.
- Das DN, Puthusseri B, Gopu V, Krishnan V, Bhagavath AK, Bolla S, Saini Y, Criner GJ, Marchetti N, Tang H, Konduru NV, Fan L, Shetty S. Caveolin-1-derived peptide attenuates cigarette smoke-induced airway and alveolar epithelial injury. Am J Physiol Lung Cell Mol Physiol. 2023 Nov 1;325(5):L689-L708. doi: 10.1152/ajplung.00178.2022. PMID: 37642665. PMCID: PMC11178264.
- Sundar IK, Duraisamy SK, Choudhary I, Saini Y, Silveyra P. Acute and Repeated Ozone Exposures Differentially Affect Circadian Clock Gene Expression in Mice. Adv Biol (Weinh). 2023 Nov;7(11):e2300045. doi: 10.1002/adbi.202300045. PMID: 37204107; PMCID: PMC10657336.
- Mao Y, Patial S, Saini Y. Airway epithelial cell-specific deletion of HMGB1 exaggerates inflammatory responses in mice with muco-obstructive airway disease. Front Immunol. 2023 Jan 19;13:944772. doi: 10.3389/fimmu.2022.944772. PMID: 36741411; PMCID: PMC9892197.
- Vo T, Saini Y. Case report: Mafb promoter activity may define the alveolar macrophage dichotomy. Front Immunol. 2022 Dec 12;13:1050494. doi: 10.3389/fimmu.2022.1050494. PMID: 36578483; PMCID: PMC9791191.
- Kumar R, Mao Y, Patial S, Saini Y. Induction of whole-body gene deletion via R26-regulated tamoxifen-inducible Cre recombinase activity. Front Pharmacol. 2022 Dec 8;13:1018798. doi: 10.3389/fphar.2022.1018798. PMID: 36569322; PMCID: PMC9772612.
- Lamichhane R, Patial S, Saini Y. Higher susceptibility of males to bleomycin-induced pulmonary inflammation is associated with sex-specific transcriptomic differences in myeloid cells. Toxicol Appl Pharmacol. 2022 Nov 1;454:116228. doi: 10.1016/j.taap.2022.116228. PMID: 36087614; PMCID: PMC9793441.
- Lewis BW, Patial S, Saini Y. In Vitro Screening Method for Characterization of Macrophage Activation Responses. Methods Protoc. 2022 Aug 30;5(5):68. doi: 10.3390/mps5050068. PMID: 36136814; PMCID: PMC9498385.
- Vo T, Paudel K, Choudhary I, Patial S, Saini Y. Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2. Sci Rep. 2022 Jan 25;12(1):1357. doi: 10.1038/s41598-022-04906-8. PMID: 35079032; PMCID: PMC8789794.
