First-Author Cell Chemical Biology Publication by Amanda Graboski From the Redinbo Lab

Congratulations to Amanda Graboski, graduate student from the Redinbo Lab, for her first-author paper in Cell Chemical Biology on the development of (3S) ALG-05 to reduce indole production, holding promise for mitigating indoxyl sulfate accumulation in chronic kidney disease!

The article titled, “Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate,” was published in Cell Chemical Biology on August 12, 2023. Matthew R. Redinbo, Ph.D., is the senior author of the paper.

“In brief, Graboski et al. developed a mechanism-based inhibitor, (3S) ALG-05, that displays pan activity against diverse tryptophanases from the human gut microbiome. (3S) ALG-05 is non-toxic and reduces levels of indoxyl sulfate in mice, showing potential promise for the treatment of chronic kidney disease.

Figure from Graboski et al. where they develop a mechanismbased inhibitor, (3S) ALG-05, that displays pan activity against diverse tryptophanases from the human gut microbiome. — The development of (3S) ALG-05 to reduce indole production, holding promise for mitigating indoxyl sulfate accumulation in chronic kidney disease.

Full citation: Graboski, Amanda L et al. “Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate.” Cell chemical biology, S2451-9456(23)00244-1. 12 Aug. 2023

~ The abstract and figure above are from the article, “Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate” published in Cell Chemical Biology

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