We are happy to announce the promotion of Dr. Nicholas Brown to the rank of Associate Professor, effective September 29th, 2023!
We thank Nick for his dedication and contributions to the department and congratulate him on this well-deserved promotion.
Research at the Brown Lab centers around unraveling the intricate system of inter- and intra-molecular interactions that dynamically regulate the catalytic mechanisms of enzymes, with a specific focus on their roles in the cell cycle. Their research approach has been truly interdisciplinary, combining techniques such as enzyme kinetics, mutagenesis, X-ray crystallography, NMR spectroscopy, and cryogenic electron microscopy (cryo-EM) to characterize these molecular machines. Their recent paper in Nature Structural & Molecular Biology, employing time-resolved cryogenic cryo-EM and Deep Reconstructing Generative Networks (cryoDRGN), unveiled the specific mechanisms of APC/C – a crucial protein complex involved in substrate polyubiquitination. The Brown Lab’s work provides invaluable mechanistic insights into the cell cycle, with future implications for the design of cancer therapeutics.