Yen-Yu Ian Shih, PhD

Assistant Professor, Department of Neurologyshih
Director, Small Animal MRI, Biomedical Research Imaging Center



  • Ph.D. in Biomedical Engineering, National Taiwan University, Taiwan 2008
  • Postdoctoral Fellow, Functional and Micro-Magnetic Resonance Imaging Center, Academia Sinica, Taiwan 2009
  • American Heart Association Postdoctoral Fellow/Head of Animal MRI Section, Research Imaging Institute, University of Texas Health Science Center at San Antonio, Texas 2011


Selected Publications:

  • Chen CC, Shih YY, and Chang C, "Dopaminergic imaging of nonmotor manifestations in a rat model of Parkinson's disease by fMRI," Neurobiol Dis, 2012;49C:99-106.
  • Shih YY, Muir ER, Li G, De La Garza BH, and Duong TQ, "High resolution 3D microangiography of the rat ocular circulation," Radiology, 2012; 264(1):234-241
  • Shih YY, Chiang YC, Shyu BC, Jaw FS, Duong TQ and Chang C, "Endogenous opioid-dopamine neurotransmission underlie negative CBV fMRI signals" Exp Neurol, 2012; 234(2):382-8.
  • Shih YY, Li G, Muir ER, De La Garza BH, Kiel JW, and Duong TQ, "Pharmacological MRI of the retina: blood flow and BOLD responses during nitroprusside infusion," Magn Reson Med, 2012;68(4):1273-8.
  • Shih YY, Hsu YH, Duong TQ, Lin SS, Chow KP, and Chang C, "Longitudinal study of tumor-associated macrophages during tumor expansion using MRI," NMR Biomed 2011;24(10):1353–60.
  • Shih YY, De La Garza BH, Muir ER, Rogers WE, Harrison, JM, Kiel JW, and Duong TQ, "Lamina-specific fMRI responses to visual stimulation of the rat retina," Invest Ophthalmol Vis Sci, 2011;52(8):5303-10.
  • Shih YY, Wey HY, De La Garza BH, and Duong TQ, "Striatal and cortical BOLD, blood flow, blood volume, oxygen consumption, and glucose consumption changes in noxious forepaw electrical stimulation," J Cereb Blood Flow Metab, 2011;31(3):832-41.
  • Shih YY, Chen CC, Shyu BC, Lin ZJ, Chiang YC, Jaw FS, Chen YY, and Chang C, "A new scenario for negative functional magnetic resonance imaging signals: endogenous neurotransmision," J Neurosci 2009;29(10):3036-44. See also J Neurosci, 2009;29(10):i and Research Highlight in the Nat Rev Neurosci, 2009;10(5):316.
  • Shih YY, Chiang YC, Chen JC, Huang CH, Chen YY, Liu RS, Chang C, and Jaw FS, "Brain nociceptive imaging in rats using 18f-fluorodeoxyglucose small-animal positron emission tomography,"  Neuroscience, 2008;155(4):1221-6.
  • Shih YY, Chen YY, Chen CC, Chen JC, Chang C, and Jaw FS, "Whole brain fMRI mapping of acute nociceptive responses induced by formalin in rats using atlas registration based event related analysis," J Neurosci Res, 2008;86(8):1801-11.

Office: 3104 Bioinformatics Building; 130 Mason Farm Rd, CB# 7513, Chapel Hill, NC 27599
Telephone: 919-843-4729
Email: shihy[at]
Experimental Neuroimaging Laboratory