April 20, 2020
UNC Blood Research Center member Dougald Monroe along with Keith Neeves of the University of Colorado in Denver are investigators on a newly funded NIH NHLBI grant. The grant, R01HL151984, which was awarded four years of funding is titled An integrated computational and experimental approach to understanding the hemostatic response during treatment of bleeding. These …
April 10, 2020
Congratulations to Jean Marie Mwiza, a graduate research assistant in Dr. Bergmeier’s Lab, for recently receiving a prestigious predoctoral fellowship from AHA. Jean Marie’s fellowship provides stipend support for 2 years for his project, titled “Determining the Platelet Signaling Pathway(s) Critical in Venous Thrombosis Pathogenesis”.
March 27, 2020
Nigel Key, MD, the Harold R. Roberts Distinguished Professor of Medicine and Pathology and director of the UNC Blood Research Center published a study that identifies the intrinsic coagulation pathway as a potential target to prevent thrombotic and inflammatory complications after RBC transfusion. The article “Red blood cell microvesicles activate the contact system, leading to …
March 27, 2020
Nigel S. Key, MB, ChB, FRCP Nigel Key, MB ChP FRCP, the Harold R. Roberts Distinguished Professor of Medicine and Pathology and director of the UNC Blood Research Center (BRC) has published important findings on the mechanism of thrombin generation induced by stored red blood cells (sRBC). In a recent study, first author Denis Noubouossie, …
March 26, 2020
High fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice Abstract: Obesity is a prevalent prothrombotic risk factor marked by enhanced fibrin formation and suppressed fibrinolysis. Fibrin both promotes thrombotic events and drives obesity pathophysiology, but a lack of essential analytical tools has left fibrinolytic mechanisms affected by obesity poorly defined. Using a …
March 20, 2020
Congratulations to Wolfgang Bergmeier, Ph.D., Associate Professor, Department of Biochemistry and Biophysics, in collaboration with a multi-institutional team, for publishing article in the journal Science Advances. Dr. Bergmeier and the team explain why platelet responses are associated with organ injury and mortality after cardiac surgeries and how platelets cause local and systemic inflammation via mast …
December 12, 2019
Dr. Marcus Carden is a Med/Peds hematologist who is part of the hematology faculty in the Departments of Pediatrics and Medicine at the UNC School of Medicine as an Assistant Professor and as the Director of the Pediatric Sickle Cell program. As a clinician for both pediatric and adult patients with sickle cell at UNC, he is actively engaged in clinical and translational research projects aiming to improve the lives of patients across the lifespan.
August 8, 2017
Aberrant release of platelets into bone marrow of mice lacking Arp2/3 function in the megakaryocytic lineage. Whole-mount staining of femur bone marrow is shown. Green staining indicates platelets and megakaryocytes, red staining indicates endothelial cells, and blue staining indicates nuclei. See the article by Paul et al.