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Neil Alexis, Ph.D.

Professor, Department of Pediatrics

H.B.Sc., University of Toronto, 1984
M.H.Sc., University of Toronto, 1988
Ph.D., University of Toronto, 1997
Postdoc, University of North Carolina, 2000
Joined the Center in 1997

Research Interests

My research focuses on examining host defense responses in the airway in diseases such as asthma and copd as well as how inhaled pollutants alter these responses in exposed humans. My recent interests include examining the effects of vaping on lung macrophages and how macrophage immunometabolic profiles change depending on their anatomic location in the respiratory tract. Finally, my research includes establishing and maintaining the CEMALB Biorepository, where we house over 10,000 biological samples for research interrogation.

 

Lab Personnel

Heather Wells, Research Specialist

Jamie Antinori, Research Technician

Isabela DeJohn, Work Study

Jessica Chlebowski, Work Study

Markus Parson, Work Study

 

 

 

Selected Publications

1. Wu T, Huang J, Moore PJ, Little MS, Walton WG, Fellner RC, Alexis NE, Peter Di Y, Redinbo MR, Tilley SL, Tarran R. Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor. Na. Commun. 2017 Feb 6;7:42214.

2. Maestre-Batlle D, Pena OM, Hirota JA, Gunawan E, Rider CF, Sutherland D, Alexis NE, Carlsten C. Novel flow cytometry approach to identify bronchial epithelial cells from healthy human airways.Sc Rp. 2017 Feb 6;7:42214.

3. Alexis NE, Bennett WD, Peden DB. Safety and Benefits of Inhaled Hypertonic Saline Following Airway Challenges with Endotoxin and Allergen in Asthmatics. J asthma 2017 Jan 17:0.

4. Bennett WE, Ivins S, Alexis NE, Wu J, Bromberg PA, Brar SS, Travlos G, London SJ. Effect of Obesity on Acute Ozone-Induced Changes in Airway Function, Reactivity and Inflammation in Adult Females. PLoS One 2016 Aug 11;11(8):e0160030.

5. Sesma JI, Weitzer CD, Livraghi-Butrico A, Dang H, Donaldson S, Alexis NE, Jacobson KA, Harden TK, Lazarowski ER. UDP-glucose promotes neutrophil recruitment in the lung.Purinergic Signal 2016 Dec; 12(4):627-635.

6. Kobernick AK, Peden DB, Zhou H, Zhou Q, Dillon MA, Alexis NE. Reproducibility of the inflammatory response to inhaled endotoxin in healthy volunteers. J Allergy Clin Immunol 2016 Oct; 138(4):1205-1207.

7. Alexis NE, Carlsten C. Interplay of air pollution asthma immunopathogenesis: a focus review of diesel exhaust and ozone. Int’l Immunopharmacol. 2014 Nov; 23(1):347-355.