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“Transforming Care and Inspiring Hope for all children…”

Ongoing Clinical Trials

Available clinical trials in the UNC Department of Pediatrics vary by division, specialty or center. Additional information about clinical trials and their availability may be found by visiting Research for Me, which is administered by the North Carolina Translational and Clinical Sciences Institute (NCTraCS), or ClinicalTrials.gov. For divisions with active or ongoing clinical trials, experienced research teams include both clinicians and coordinators who specialize in care and management of pediatric populations impacted by common or rare diseases.

It is important to note that while some clinical trials are open and enrolling, others are closed or maintain waitlists for prospective participants. Also, some clinical trials are administered by faculty from the Department of Pediatrics, but only recruit adults.

Area of StudyStudy TitleTarget AgeContact Information
Adolescent Health and Well-BeingCognition and Neuroimaging in TeensElementary, TeenHannah Waltz
919-843-9671
Adolescent Health and Well-BeingEVOLVE Study: Understanding risk for depression in the pubertal transitionElementary, TeenElizabeth Andersen
evolvestudy@unc.edu
Adolescent Health and Well-BeingProNET: Psychosis Risk Outcomes NetworkElementary, TeenJennifer Nieri
jennifer_nieri@med.unc.edu
877-774-6319
Adolescent Health and Well-BeingPathways to Adolescent SuccessTeenAysenil Belger
Aysenil.belger@unc.edu
919-843-7368
Adolescent Health and Well-BeingTeen Cycle StudyTeenAriana Davis
ariana.davis@unc.edu
Adolescent Health and Well-BeingAdolescent Mood during Puberty and Testosterone (AMPT)TeenKayla Jensen
NERDlab@unc.edu
919-445-6815
Adolescent Health and Well-BeingPathways to Adolescent SuccessTeenAysenil Belger
uncpass@unc.edu
919-843-7368
AllergiesPeanut Allergy Immunotherapy StudyPreschool, Elementary, Teen, AdultLauren Herlihy
lekoch@email.unc.edu
AllergiesPeanut Allergy Study for Children and AdolescentsPreschool, ElementaryLauren Herlihy
919-962-4406
AsthmaUNC Asthma Registry for KidsInfant, Preschool, Elementary, Teen, AdultMiriam Davis
919-966-2333
AsthmaEAGLE: Efficacy Assessment in recurrent wheezing childrenElementary, Teen, AdultSheila Joshi
Sheila_Joshi@unc.edu
919-843-1577
Bones, Joints and MusclesBones, Joints and MusclesElementary, Teen, AdultCourtney Chaaban
rosscj@live.unc.edu
Bones, Joints and MusclesACL Surgery Rehabilitation StudyTeen, AdultTroy Blackburn
troyb@email.unc.edu
Bones, Joints and MusclesBiomechanical Changes Following ACL Injury that Influence PTOATeen, AdultBrian Pietrosimone
pietrosi@email.unc.edu
Bones, Joints and MusclesPediatric ACL Walking, Jumping, and CuttingElementary, Teen, AdultElizabeth Bjornsen
ebjornse@live.unc.edu
Bones, Joints and MusclesVirtual Reality ACL Reconstruction StudyTeenShelby Baez
sbaez@unc.edu
Bones, Joints and MusclesImproving Walking Patterns in Individuals with an ACL ReconstructionTeen, AdultCortney Armitano
919-962-0396
Bones, Joints and MusclesBrain Function after ACL ReconstructionTeen, AdultShelby Baez
sbaez@unc.edu
Bones, Joints and MusclesSimple Bone Cysts in Kids (SBoCK)Preschool, Elementary, Teen, AdultJulie Titter
919-966-5495
CancerAdministration of Autologous CAR-T Cells Targeting the CD19 Antigen and Containing the Inducible Caspase 9 Safety Switch in Patient with Acute Lymphoblastic LeukemiaPreschool, Elementary, Teen, AdultCatherine Cheng
Spencer Laing
919-445-4208
CancerTargeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)Infant, Preschool, Elementary, Teen, AdultJuanita Ramirez
877-668-0683
CancerETERNITY: Biorepository to accelerate advances in Radiation TherapyInfant, Preschool, Elementary, Teen, AdultMelissa Knutsen
919-966-4432
CancerExpanded Access Protocol Using 131I-MIBGInfant, Preschool, Elementary, Teen, AdultJuanita Ramirez
919-966-5785
CancerA Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)Infant, Preschool, Elementary, Teen, AdultKimberly Kasow
919-966-1178
CancerNab-Paclitaxel and Gemcitabine for Recurrent/Refractory SarcomaElementary, Teen, AdultJuanita Cuffee
919-843-7025
CancerStudy of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory NeuroblastomaPreschool, Elementary, Teen, AdultCatherine Cheng
Spencer Laing
919-445-4208
CancerStudy of CD30 CAR for Relapsed/Refractory CD30+ HL and CD30+ NHLPreschool, Elementary, Teen, AdultCatherine Cheng
Spencer Laing
919-445-4208
CancerUnderstanding Outcome Differences in Adolescents and Young Adults with Acute Lymphoblastic Leukemia (ALL)Teen, Adultcancerclinicaltrials@med.unc.edu
919-966-4432
CancerUNC Childhood, Adolescent, and Young Adult Cancer RegistryInfant, Preschool, Elementary, Teen, AdultAndrew Smitherman, MD MSc
andrew_smitherman@med.unc.edu
919-966-1178
CancerImprove Adherence to Childhood Cancer SurvivorshipInfant, Preschool, Elementary, Teen, AdultLineberger Clinical Research
cancerclinicaltrials@med.unc.edu
919-966-4432
CancerPediatric Oncology Tissue to Support Further ResearchInfant, Preschool, Elementary, Teen, AdultLineberger Clinical Research
cancerclinicaltrials@med.unc.edu
919-966-4432
CancerMeasuring body composition in childhood cancerElementary, Teen, AdultLineberger Clinical Research
cancerclinicaltrials@med.unc.edu
919-966-4432
COVID-19The PREVNC StudyInfant, Preschool, Elementary, Teen, AdultKatie Mills
PREVNCstudy@unc.edu
COVID-19Long-term immunologic responses to COVID-19 infection and vaccinationElementary, Teen, AdultUsaphea P. Vanna
usaphea@ad.unc.edu
Dental Healthwater from Bottles to Establish Strong Teeth (waterBEST)InfantSonya K Capps
sonya_capps@unc.edu
919-537-3269
Dental HealthDental Anxiety in Young Dental PatientsPreschool, ElementaryNare Ghaltakhchyan
jlab@unc.edu
984-234-1858
Developmental DisordersIBIS Early Prediction StudyInfant, PreschoolShannon Sweeney
919-843-1331
Developmental DisordersRegistry for Autism, Fragile X Syndrome, and Intellectual and Developmental DisabilitiesInfant, Preschool, Elementary, Teen, AdultRenee Clark
919-966-5232
Developmental DisordersFLASH StudyInfant, PreschoolJessica Steinbrenner
flash_study@unc.edu
Developmental DisordersStudying brain development in infants with developmental disordersInfant, PreschoolJulia Gross
julia_gross@med.unc.edu
919-966-8032
DiabetesType 1 Diabetes RegistryInfant, Preschool, Elementary, Teen, AdultKlara Klein
klara_klein@med.unc.edu
DiabetesDeveloping treatments for type 1 diabetesElementary, Teen, AdultRoland Tisch
919-966-4766
Down SyndromeIBIS Down Syndrome Imaging StudyInfant, PreschoolShannon Sweeney
919-843-1331
Ear, Nose and ThroatCochlear Implants for Babies and Toddlers with Single-Sided DeafnessInfant, Preschool, Elementary, Teen, AdultMichelle Bocanegra
CIResearch@unc.edu
Eating, Nutrition, and MetabolismARFID Genes and EnvironmentElementary, Teen, AdultMelissa Chernoff
melissa_chernoff@med.unc.edu
EczemaEczema Research StudyElementary, Teen, AdultLauren Herlihy
lekoch@email.unc.edu
Eosinophilic EsophagitisEoE Tooth Fairy Study: Environmental Risk Factors for Eosinophilic Esophagitis (EoE)Preschool, Elementary, Teen,Kacie Walker
toothfairystudy@med.unc.edu
Eosinophilic EsophagitisIndividualized Diet Elimintation for Treatment of Eosinophilic Esophagitis (EoE)Teen, AdultTim Gee
timothy_gee@med.unc.edu
Hearing LossChildren with Hearing Loss Sleep StudyElementaryJulia Drouin
allearslab@med.unc.edu
Inflammatory, Allergic, and Chronic Gastrointestinal DiseasesTissue Repository for Inflammatory & Allergic Chronic GI diseasesInfant, Preschool, Elementary, TeenAshley Wolber
ashleywolber@unc.edu
919-904-0746
Inflammatory Bowel DiseaseThe Pediatric IBD Network Improvement CollaborativePreschool, Elementary, Teen, AdultParis Bennett
paris_bennett@med.unc.edu
Kidney DiseaseCureGN (Cure Glomerulonephropathy)Infant, Preschool, Elementary, Teen, AdultMaggie D'Angelo
919-619-1773
Kidney DiseaseGDCN RegistryInfant, Preschool, Elementary, Teen, AdultKristin Brock
919-445-2623
Kidney DiseaseEvaluating Problematic Proteinuria in Kids (EPPIK)Infant, Preschool, Elementary, TeenAnne Froment
kidneytrials@unc.edu
919-445-2622
Medication and Vaccine EfficacyPharmacokinetics and Safety of Drugs in Lactating Women and Breastfed InfantsInfant, Teen, AdultJennifer Talbert
984-974-7865
jtalbert@med.unc.edu
Medication and Vaccine EfficacyPharmacokinetics of Off Label Pediatric MedicationsInfant, Preschool, ElementaryJennifer Talbert
984-974-7865
jtalbert@med.unc.edu
Medication and Vaccine EfficacySafety of Sildenafil in Premature Infants (SIL02)InfantJennifer Talbert
984-974-7865
jtalbert@med.unc.edu
Medication and Vaccine EfficacyPharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS or POP02)Infant, Preschool, Elementary, Teen, AdultJennifer Talbert
984-974-7865
jtalbert@med.unc.edu
Multiple ScelrosisPediatric Relapsing Remitting Multiple Sclerosis StudyElementary, Teen, AdultPatricia Orozco
919-966-5039
Nephrotic SyndromeINShore: is the drug obinutizumab helpful in children with nephrotic syndrome?Preschool, Elementary, Teen, AdultFernanda Ochoa Toro
feroacha@med.unc.edu
NeurodevelopmentEarly Life Factors (ELF) StudyInfant, AdultThao Nguyen
ELFstudy@unc.edu
919-445-2869
NutritionMinds & MilkshakesTeenBrian Brown
NIBL@unc.edu
919-843-4975
NutritionInfant Nutrition & Cognition StudyInfant, AdultMelissa Shaffer
704-250-5018
NutritionAn avocado intervention to increase the nutrient quality of human milk in support of infant cognitive developmentInfantMandi Rider
feedingbrains@unc.edu
704-250-5018
OsteoarthritisMove with Support - Muevete con ApoyoTeen, AdultSandra Soto
919-966-4298
PIK3CA Related Overgrowth SyndromesPIK3CA Related Overgrowth Syndromes (PROS) Clinical TrialElementary, Teen, AdultJulie Blatt
919-966-0590
Sickle Cell DiseaseEarly Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell TransplantationPreschool, ElementaryKimberly Kasow
919-966-1178
Speech, Dentofacial AbnormalitiesOrthognathic Speech Pathology: Phonetic Contrasts of Patients With Dental Discrepancies Pre- and Post-Treatment Analyses (OSP)Teen, AdultSherrill Phillips
sherrill_phillips@unc.edu
Tuberous Sclerosis ComplexRegulating Together in TSCElementary, Teen, AdultJustin Birudavol
justin.birudavol@cidd.unc.edu