Ongoing Clinical Trials
Available clinical trials in the UNC Department of Pediatrics vary by division, specialty or center. Additional information about clinical trials and their availability may be found by visiting Research for Me, which is administered by the North Carolina Translational and Clinical Sciences Institute (NCTraCS), or ClinicalTrials.gov. For divisions with active or ongoing clinical trials, experienced research teams include both clinicians and coordinators who specialize in care and management of pediatric populations impacted by common or rare diseases.
It is important to note that while some clinical trials are open and enrolling, others are closed or maintain waitlists for prospective participants. Also, some clinical trials are administered by faculty from the Department of Pediatrics, but only recruit adults.
| Area of Study | Study Title | Target Age | Contact Information |
|---|---|---|---|
| Adolescent Health and Well-Being | Cognition and Neuroimaging in Teens | Elementary, Teen | Hannah Waltz 919-843-9671 |
| Adolescent Health and Well-Being | EVOLVE Study: Understanding risk for depression in the pubertal transition | Elementary, Teen | Elizabeth Andersen evolvestudy@unc.edu |
| Adolescent Health and Well-Being | ProNET: Psychosis Risk Outcomes Network | Elementary, Teen | Jennifer Nieri jennifer_nieri@med.unc.edu 877-774-6319 |
| Adolescent Health and Well-Being | Stories of high schooler activity participation after a health event | Teen | Rachel Vaughn rachel_vaughn@med.unc.edu |
| Adolescent Health and Well-Being | High Schoolers and Activities after an Unexpected Health Event | Teen | Rachel Vaughn rachel_vaughn@med.unc.edu |
| Adolescent Health and Well-Being | Teen Cycle Study | Teen | Ariana Davis ariana.davis@unc.edu |
| Adolescent Health and Well-Being | Adolescent Mood during Puberty and Testosterone (AMPT) | Teen | Kayla Jensen NERDlab@unc.edu 919-445-6815 |
| Allergies | Peanut Allergy Immunotherapy Study | Preschool, Elementary, Teen, Adult | Lauren Herlihy lekoch@email.unc.edu |
| Asthma | UNC Asthma Registry for Kids | Infant, Preschool, Elementary, Teen, Adult | Miriam Davis 919-966-2333 |
| Bones, Joints and Muscles | Bones, Joints and Muscles | Elementary, Teen, Adult | Courtney Chaaban rosscj@live.unc.edu |
| Bones, Joints and Muscles | ACL Surgery Rehabilitation Study | Teen, Adult | Troy Blackburn troyb@email.unc.edu |
| Bones, Joints and Muscles | Biomechanical Changes Following ACL Injury that Influence PTOA | Teen, Adult | Brian Pietrosimone pietrosi@email.unc.edu |
| Bones, Joints and Muscles | Pediatric ACL Walking, Jumping, and Cutting | Elementary, Teen, Adult | Elizabeth Bjornsen ebjornse@live.unc.edu |
| Bones, Joints and Muscles | Virtual Reality ACL Reconstruction Study | Teen | Shelby Baez sbaez@unc.edu |
| Bones, Joints and Muscles | Improving Walking Patterns in Individuals with an ACL Reconstruction | Teen, Adult | Cortney Armitano 919-962-0396 |
| Bones, Joints and Muscles | Brain Function after ACL Reconstruction | Teen, Adult | Shelby Baez sbaez@unc.edu |
| Bones, Joints and Muscles | Simple Bone Cysts in Kids (SBoCK) | Preschool, Elementary, Teen, Adult | Julie Titter 919-966-5495 |
| Cancer | Administration of Autologous CAR-T Cells Targeting the CD19 Antigen and Containing the Inducible Caspase 9 Safety Switch in Patient with Acute Lymphoblastic Leukemia | Preschool, Elementary, Teen, Adult | Catherine Cheng Spencer Laing 919-445-4208 |
| Cancer | Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial) | Infant, Preschool, Elementary, Teen, Adult | Juanita Ramirez 877-668-0683 |
| Cancer | Expanded Access Protocol Using 131I-MIBG | Infant, Preschool, Elementary, Teen, Adult | Juanita Ramirez 919-966-5785 |
| Cancer | A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) | Infant, Preschool, Elementary, Teen, Adult | Kimberly Kasow 919-966-1178 |
| Cancer | Nab-Paclitaxel and Gemcitabine for Recurrent/Refractory Sarcoma | Elementary, Teen, Adult | Juanita Cuffee 919-843-7025 |
| Cancer | Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma | Preschool, Elementary, Teen, Adult | Catherine Cheng Spencer Laing 919-445-4208 |
| Cancer | Study of CD30 CAR for Relapsed/Refractory CD30+ HL and CD30+ NHL | Preschool, Elementary, Teen, Adult | Catherine Cheng Spencer Laing 919-445-4208 |
| Cancer | Venetoclax and Azacitidine in Patients with Acute Myeloid Leukemia after Transplant | Teen, Adult | Janell Markey janell_markey@med.unc.edu 919-966-1568 |
| Cancer | Understanding Outcome Differences in Adolescents and Young Adults with Acute Lymphoblastic Leukemia (ALL) | Teen, Adult | cancerclinicaltrials@med.unc.edu 919-966-4432 |
| Cancer | UNC Childhood, Adolescent, and Young Adult Cancer Registry | Infant, Preschool, Elementary, Teen, Adult | Andrew Smitherman, MD MSc andrew_smitherman@med.unc.edu 919-966-1178 |
| Cancer | Improve Adherence to Childhood Cancer Survivorship | Infant, Preschool, Elementary, Teen, Adult | Lineberger Clinical Research cancerclinicaltrials@med.unc.edu 919-966-4432 |
| Cancer | Pediatric Oncology Tissue to Support Further Research | Infant, Preschool, Elementary, Teen, Adult | Lineberger Clinical Research cancerclinicaltrials@med.unc.edu 919-966-4432 |
| Cancer | Measuring body composition in childhood cancer | Elementary, Teen, Adult | Lineberger Clinical Research cancerclinicaltrials@med.unc.edu 919-966-4432 |
| COVID-19 | Epidemiological and Immunological Aspects of COVID-19 | Infant, Preschool, Elementary, Teen, Adult | Michelle Kennedy 984-209-3326 |
| COVID-19 | The PREVNC Study | Infant, Preschool, Elementary, Teen, Adult | Katie Mills PREVNCstudy@unc.edu |
| COVID-19 | Long-term immunologic responses to COVID-19 infection and vaccination | Elementary, Teen, Adult | Usaphea P. Vanna usaphea@ad.unc.edu |
| Dental Health | water from Bottles to Establish Strong Teeth (waterBEST) | Infant | Sonya K Capps sonya_capps@unc.edu 919-537-3269 |
| Dental Health | Dental Anxiety in Young Dental Patients | Preschool, Elementary | Nare Ghaltakhchyan jlab@unc.edu 984-234-1858 |
| Developmental Disorders | IBIS Early Prediction Study | Infant, Preschool | Shannon Sweeney 919-843-1331 |
| Developmental Disorders | Registry for Autism, Fragile X Syndrome, and Intellectual and Developmental Disabilities | Infant, Preschool, Elementary, Teen, Adult | Renee Clark 919-966-5232 |
| Developmental Disorders | FLASH Study | Infant, Preschool | Jessica Steinbrenner flash_study@unc.edu |
| Developmental Disorders | Gender and Autism Project | Elementary, Teen, Adult | Sallie Nowell GAP@unc.edu |
| Developmental Disorders | Studying brain development in infants with developmental disorders | Infant, Preschool | Julia Gross julia_gross@med.unc.edu 919-966-8032 |
| Diabetes | Type 1 Diabetes Registry | Infant, Preschool, Elementary, Teen, Adult | Klara Klein klara_klein@med.unc.edu |
| Diabetes | Developing treatments for type 1 diabetes | Elementary, Teen, Adult | Roland Tisch 919-966-4766 |
| Ear, Nose and Throat | Cochlear Implants for Babies and Toddlers with Single-Sided Deafness | Infant, Preschool, Elementary, Teen, Adult | Michelle Bocanegra CIResearch@unc.edu |
| Eating, Nutrition, and Metabolism | ARFID Genes and Environment | Elementary, Teen, Adult | Melissa Chernoff melissa_chernoff@med.unc.edu |
| Eczema | Eczema Research Study | Elementary, Teen, Adult | Lauren Herlihy lekoch@email.unc.edu |
| Eosinophilic Esophagitis | EoE Tooth Fairy Study: Environmental Risk Factors for Eosinophilic Esophagitis (EoE) | Preschool, Elementary, Teen, | Kacie Walker toothfairystudy@med.unc.edu |
| Eosinophilic Esophagitis | Individualized Diet Elimintation for Treatment of Eosinophilic Esophagitis (EoE) | Teen, Adult | Tim Gee timothy_gee@med.unc.edu |
| Eosinophilic Esophagitis | Eosinophilic Esophagitis Drug Trial | Teen, Adult | Loyanna Hubbard loyanna_hubbard@med.unc.edu |
| Inflammatory, Allergic, and Chronic Gastrointestinal Diseases | Tissue Repository for Inflammatory & Allergic Chronic GI diseases | Infant, Preschool, Elementary, Teen | Ashley Wolber ashleywolber@unc.edu 919-904-0746 |
| Inflammatory Bowel Disease | The Pediatric IBD Network Improvement Collaborative | Preschool, Elementary, Teen, Adult | Paris Bennett paris_bennett@med.unc.edu |
| Juvenile Arthritis | Investigating Biologic Drugs in Children with Arthritis | Infant, Preschool, Elementary, Teen, Adult | Teresa Dickson tad6@med.unc.edu 919-962-8241 |
| Kidney Disease | CureGN (Cure Glomerulonephropathy) | Infant, Preschool, Elementary, Teen, Adult | Maggie D'Angelo 919-619-1773 |
| Kidney Disease | GDCN Registry | Infant, Preschool, Elementary, Teen, Adult | Kristin Brock 919-445-2623 |
| Kidney Disease | Evaluating Problematic Proteinuria in Kids (EPPIK) | Infant, Preschool, Elementary, Teen | Anne Froment kidneytrials@unc.edu 919-445-2622 |
| Lupus | Aurora VOCAL Study for Adolescents with Lupus Nephritis | Teen | Anne Froment kidneytrials@unc.edu |
| Medication and Vaccine Efficacy | Pharmacokinetics and Safety of Drugs in Lactating Women and Breastfed Infants | Infant, Teen, Adult | Jennifer Talbert 984-974-7865 jtalbert@med.unc.edu |
| Medication and Vaccine Efficacy | Pharmacokinetics of Off Label Pediatric Medications | Infant, Preschool, Elementary | Jennifer Talbert 984-974-7865 jtalbert@med.unc.edu |
| Medication and Vaccine Efficacy | Safety of Sildenafil in Premature Infants (SIL02) | Infant | Jennifer Talbert 984-974-7865 jtalbert@med.unc.edu |
| Medication and Vaccine Efficacy | Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS or POP02) | Infant, Preschool, Elementary, Teen, Adult | Jennifer Talbert 984-974-7865 jtalbert@med.unc.edu |
| Medication and Vaccine Efficacy | Study for Patients with Respiratory Infections After Bone Marrow Transplant | Teen, Adult | Stephanie Morales stephanie_morales@med.unc.edu |
| Mental and Emotional Health | Latina Mother and Child Immune Health Study | Preschool, Adult | Rebeca Alvarado Harris rebeca@email.unc.edu |
| Multiple Scelrosis | Pediatric Relapsing Remitting Multiple Sclerosis Study | Elementary, Teen, Adult | Patricia Orozco 919-966-5039 |
| Nephrotic Syndrome | INShore: is the drug obinutizumab helpful in children with nephrotic syndrome? | Preschool, Elementary, Teen, Adult | Fernanda Ochoa Toro feroacha@med.unc.edu |
| Neurodevelopment | Genetic Determinants of Neurological and Developmental Disorders | Infant, Preschool, Elementary, Teen, Adult | Sheila Joshi 919-966-9051 |
| Neurodevelopment | Pediatric Brain Imaging Study | Infant, Preschool, Elementary | Jordan Jimenez jordan_jimenez@med.unc.edu |
| Neurodevelopment | Early Life Factors (ELF) Study | Infant, Adult | Thao Nguyen ELFstudy@unc.edu 919-445-2869 |
| Nutrition | Infant Nutrition & Cognition Study | Infant, Adult | Melissa Shaffer 704-250-5018 |
| Osteoarthritis | Move with Support - Muevete con Apoyo | Teen, Adult | Sandra Soto 919-966-4298 |
| PIK3CA Related Overgrowth Syndromes | PIK3CA Related Overgrowth Syndromes (PROS) Clinical Trial | Elementary, Teen, Adult | Julie Blatt 919-966-0590 |
| Sickle Cell Disease | Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell Transplantation | Preschool, Elementary | Kimberly Kasow 919-966-1178 |
| Sickle Cell Disease | STRIDE Biorepository | Teen, Adult | Kimberly Kasow 919-966-1178 |
| Speech, Dentofacial Abnormalities | Orthognathic Speech Pathology: Phonetic Contrasts of Patients With Dental Discrepancies Pre- and Post-Treatment Analyses (OSP) | Teen, Adult | Sherrill Phillips sherrill_phillips@unc.edu |
| Tuberous Sclerosis Complex | Regulating Together in TSC | Elementary, Teen, Adult | Justin Birudavol justin.birudavol@cidd.unc.edu |