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Available clinical trials in the UNC Department of Pediatrics vary by division, specialty or center. Additional information about clinical trials and their availability may be found by visiting Research for Me, which is administered by the North Carolina Translational and Clinical Sciences Institute (NCTraCS), or For divisions with active or ongoing clinical trials, experienced research teams include both clinicians and coordinators who specialize in care and management of pediatric populations impacted by common or rare diseases.

It is important to note that while some clinical trials are open and enrolling, others are closed or maintain waitlists for prospective participants. Also, some clinical trials are administered by faculty from the Department of Pediatrics, but only recruit adults.

Area of StudyStudy TitleTarget AgeContact Information
Adolescent Health and Well-BeingCognition and Neuroimaging in TeensElementary, TeenHannah Waltz
Adolescent Health and Well-BeingEVOLVE Study: Understanding risk for depression in the pubertal transitionElementary, TeenElizabeth Andersen
Adolescent Health and Well-BeingPathways to Adolescent SuccessTeenAysenil Belger
Adolescent Health and Well-BeingStories of high schooler activity participation after a health eventTeenRachel Vaughn
Adolescent Health and Well-BeingHigh Schoolers and Activities after an Unexpected Health EventTeenRachel Vaughn
Adolescent Health and Well-BeingTeen Cycle StudyTeenAriana Davis
Adolescent Health and Well-BeingAdolescent Mood during Puberty and Testosterone (AMPT)TeenKayla Jensen
AllergiesPeanut Allergy Immunotherapy StudyPreschool, Elementary, Teen, AdultLauren Herlihy
AsthmaUNC Asthma Registry for KidsInfant, Preschool, Elementary, Teen, AdultMiriam Davis
AsthmaEAGLE: Efficacy Assessment in recurrent wheezing childrenElementary, Teen, AdultSheila Joshi
Bones, Joints and MusclesBones, Joints and MusclesElementary, Teen, AdultCourtney Chaaban
Bones, Joints and MusclesACL Surgery Rehabilitation StudyTeen, AdultTroy Blackburn
Bones, Joints and MusclesBiomechanical Changes Following ACL Injury that Influence PTOATeen, AdultBrian Pietrosimone
Bones, Joints and MusclesPediatric ACL Walking, Jumping, and CuttingElementary, Teen, AdultElizabeth Bjornsen
Bones, Joints and MusclesVirtual Reality ACL Reconstruction StudyTeenShelby Baez
Bones, Joints and MusclesImproving Walking Patterns in Individuals with an ACL ReconstructionTeen, AdultCortney Armitano
Bones, Joints and MusclesBrain Function after ACL ReconstructionTeen, AdultShelby Baez
Bones, Joints and MusclesSimple Bone Cysts in Kids (SBoCK)Preschool, Elementary, Teen, AdultJulie Titter
CancerAdministration of Autologous CAR-T Cells Targeting the CD19 Antigen and Containing the Inducible Caspase 9 Safety Switch in Patient with Acute Lymphoblastic LeukemiaPreschool, Elementary, Teen, AdultCatherine Cheng
Spencer Laing
CancerTargeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)Infant, Preschool, Elementary, Teen, AdultJuanita Ramirez
CancerExpanded Access Protocol Using 131I-MIBGInfant, Preschool, Elementary, Teen, AdultJuanita Ramirez
CancerA Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)Infant, Preschool, Elementary, Teen, AdultKimberly Kasow
CancerNab-Paclitaxel and Gemcitabine for Recurrent/Refractory SarcomaElementary, Teen, AdultJuanita Cuffee
CancerStudy of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory NeuroblastomaPreschool, Elementary, Teen, AdultCatherine Cheng
Spencer Laing
CancerStudy of CD30 CAR for Relapsed/Refractory CD30+ HL and CD30+ NHLPreschool, Elementary, Teen, AdultCatherine Cheng
Spencer Laing
CancerUnderstanding Outcome Differences in Adolescents and Young Adults with Acute Lymphoblastic Leukemia (ALL)Teen,
CancerUNC Childhood, Adolescent, and Young Adult Cancer RegistryInfant, Preschool, Elementary, Teen, AdultAndrew Smitherman, MD MSc
CancerImprove Adherence to Childhood Cancer SurvivorshipInfant, Preschool, Elementary, Teen, AdultLineberger Clinical Research
CancerPediatric Oncology Tissue to Support Further ResearchInfant, Preschool, Elementary, Teen, AdultLineberger Clinical Research
CancerMeasuring body composition in childhood cancerElementary, Teen, AdultLineberger Clinical Research
COVID-19Epidemiological and Immunological Aspects of COVID-19Infant, Preschool, Elementary, Teen, AdultMichelle Kennedy
COVID-19The PREVNC StudyInfant, Preschool, Elementary, Teen, AdultKatie Mills
COVID-19Long-term immunologic responses to COVID-19 infection and vaccinationElementary, Teen, AdultUsaphea P. Vanna
Dental Healthwater from Bottles to Establish Strong Teeth (waterBEST)InfantSonya K Capps
Dental HealthDental Anxiety in Young Dental PatientsPreschool, ElementaryNare Ghaltakhchyan
Developmental DisordersIBIS Early Prediction StudyInfant, PreschoolShannon Sweeney
Developmental DisordersRegistry for Autism, Fragile X Syndrome, and Intellectual and Developmental DisabilitiesInfant, Preschool, Elementary, Teen, AdultRenee Clark
Developmental DisordersFLASH StudyInfant, PreschoolJessica Steinbrenner
Developmental DisordersGender and Autism ProjectElementary, Teen, AdultSallie Nowell
Developmental DisordersStudying brain development in infants with developmental disordersInfant, PreschoolJulia Gross
DiabetesType 1 Diabetes RegistryInfant, Preschool, Elementary, Teen, AdultKlara Klein
DiabetesDeveloping treatments for type 1 diabetesElementary, Teen, AdultRoland Tisch
Down SyndromeIBIS Down Syndrome Imaging StudyInfant, PreschoolShannon Sweeney
Ear, Nose and ThroatCochlear Implants for Babies and Toddlers with Single-Sided DeafnessInfant, Preschool, Elementary, Teen, AdultMichelle Bocanegra
Eating, Nutrition, and MetabolismARFID Genes and EnvironmentElementary, Teen, AdultMelissa Chernoff
EczemaEczema Research StudyElementary, Teen, AdultLauren Herlihy
Eosinophilic EsophagitisEoE Tooth Fairy Study: Environmental Risk Factors for Eosinophilic Esophagitis (EoE)Preschool, Elementary, Teen,Kacie Walker
Eosinophilic EsophagitisIndividualized Diet Elimintation for Treatment of Eosinophilic Esophagitis (EoE)Teen, AdultTim Gee
Eosinophilic EsophagitisEosinophilic Esophagitis Drug TrialTeen, AdultLoyanna Hubbard
Inflammatory, Allergic, and Chronic Gastrointestinal DiseasesTissue Repository for Inflammatory & Allergic Chronic GI diseasesInfant, Preschool, Elementary, TeenAshley Wolber
Inflammatory Bowel DiseaseThe Pediatric IBD Network Improvement CollaborativePreschool, Elementary, Teen, AdultParis Bennett
Kidney DiseaseCureGN (Cure Glomerulonephropathy)Infant, Preschool, Elementary, Teen, AdultMaggie D'Angelo
Kidney DiseaseGDCN RegistryInfant, Preschool, Elementary, Teen, AdultKristin Brock
Kidney DiseaseEvaluating Problematic Proteinuria in Kids (EPPIK)Infant, Preschool, Elementary, TeenAnne Froment
LupusAurora VOCAL Study for Adolescents with Lupus NephritisTeenAnne Froment
Medication and Vaccine EfficacyPharmacokinetics and Safety of Drugs in Lactating Women and Breastfed InfantsInfant, Teen, AdultJennifer Talbert
Medication and Vaccine EfficacyPharmacokinetics of Off Label Pediatric MedicationsInfant, Preschool, ElementaryJennifer Talbert
Medication and Vaccine EfficacySafety of Sildenafil in Premature Infants (SIL02)InfantJennifer Talbert
Medication and Vaccine EfficacyPharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS or POP02)Infant, Preschool, Elementary, Teen, AdultJennifer Talbert
Medication and Vaccine EfficacyStudy for Patients with Respiratory Infections After Bone Marrow TransplantTeen, AdultStephanie Morales
Multiple ScelrosisPediatric Relapsing Remitting Multiple Sclerosis StudyElementary, Teen, AdultPatricia Orozco
NeurodevelopmentGenetic Determinants of Neurological and Developmental DisordersInfant, Preschool, Elementary, Teen, AdultSheila Joshi
NeurodevelopmentEarly Life Factors (ELF) StudyInfant, AdultThao Nguyen
NutritionInfant Nutrition & Cognition StudyInfant, AdultMelissa Shaffer
OsteoarthritisMove with Support - Muevete con ApoyoTeen, AdultSandra Soto
PIK3CA Related Overgrowth SyndromesPIK3CA Related Overgrowth Syndromes (PROS) Clinical TrialElementary, Teen, AdultJulie Blatt
Sickle Cell DiseaseEarly Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell TransplantationPreschool, ElementaryKimberly Kasow
Speech, Dentofacial AbnormalitiesOrthognathic Speech Pathology: Phonetic Contrasts of Patients With Dental Discrepancies Pre- and Post-Treatment Analyses (OSP)Teen, AdultSherrill Phillips
Tuberous Sclerosis ComplexRegulating Together in TSCElementary, Teen, AdultJustin Birudavol