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Available clinical trials in the UNC Department of Pediatrics vary by division, specialty or center. Additional information about clinical trials and their availability may be found by visiting Research for Me, which is administered by the North Carolina Translational and Clinical Sciences Institute (NCTraCS), or For divisions with active or ongoing clinical trials, experienced research teams include both clinicians and coordinators who specialize in care and management of pediatric populations impacted by common or rare diseases.

It is important to note that while some clinical trials are open and enrolling, others are closed or maintain waitlists for prospective participants. Also, some clinical trials are administered by faculty from the Department of Pediatrics, but only recruit adults.

Area of StudyStudy TitleTarget AgeContact Information
Adolescent Health and Well-BeingCognition and Neuroimaging in TeensElementary, TeenHannah Waltz
Adolescent Health and Well-BeingEVOLVE Study: Understanding risk for depression in the pubertal transitionElementary, TeenElizabeth Andersen
Adolescent Health and Well-BeingProNET: Psychosis Risk Outcomes NetworkElementary, TeenJennifer Nieri
Adolescent Health and Well-BeingTeen Cycle StudyTeenAriana Davis
AllergiesOmalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergen OIT in Food Allergic Participants (OUtMATCH)Preschool, Elementary, Teen, AdultSarah Bennick
Lauren Herlihy
AllergiesPeanut Allergy Immunotherapy StudyPreschool, Elementary, Teen, AdultLauren Herlihy
AllergiesPeanut Allergy StudyElementary, Teen, AdultEmily English
AsthmaUNC Asthma Registry for KidsInfant, Preschool, Elementary, Teen, AdultMiriam Davis
Behavior and DevelopmentBrain and Early Experiences StudyInfant, Preschool, Elementary, Teen, AdultCathi Propper
Bones, Joints and MusclesBones, Joints and MusclesElementary, Teen, AdultCourtney Chaaban
Bones, Joints and MusclesBiomechanical Changes Following ACL Injury that Influence PTOATeen, AdultBrian Pietrosimone
Bones, Joints and MusclesImproving Walking Patterns in Individuals with an ACL ReconstructionTeen, AdultCortney Armitano
Bones, Joints and MusclesSimple Bone Cysts in Kids (SBoCK)Preschool, Elementary, Teen, AdultJulie Titter
Bones, Joints and MusclesValidity of Force Detecting Insoles for Gait Biofeedback after ACLRTeen, AdultAlyssa Evans
CancerAdministration of Autologous CAR-T Cells Targeting the CD19 Antigen and Containing the Inducible Caspase 9 Safety Switch in Patient with Acute Lymphoblastic LeukemiaPreschool, Elementary, Teen, AdultCatherine Cheng
Spencer Laing
CancerTargeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)Infant, Preschool, Elementary, Teen, AdultJuanita Ramirez
CancerExpanded Access Protocol Using 131I-MIBGInfant, Preschool, Elementary, Teen, AdultJuanita Ramirez
CancerMIBG With DinutuximabPreschool, Elementary, Teen, AdultJuanita Ramirez
CancerA Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)Infant, Preschool, Elementary, Teen, AdultKimberly Kasow
CancerStudy of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory NeuroblastomaPreschool, Elementary, Teen, AdultCatherine Cheng
Spencer Laing
CancerStudy of CD30 CAR for Relapsed/Refractory CD30+ HL and CD30+ NHLPreschool, Elementary, Teen, AdultCatherine Cheng
Spencer Laing
CancerUNC Childhood, Adolescent, and Young Adult Cancer RegistryInfant, Preschool, Elementary, Teen, AdultAndrew Smitherman, MD MSc
Cerebral PalsyHand Weakness in Children with Cerebral PalsyElementary, TeenMiranda Ludovice
COVID-19Epidemiological and Immunological Aspects of COVID-19Infant, Preschool, Elementary, Teen, AdultMichelle Kennedy
COVID-19Pediatric COVID‐19 Booster Vaccine in Autoimmune Non-RespondersElementary, Teen, AdultCorinne Lawler
COVID-19The PREVNC StudyInfant, Preschool, Elementary, Teen, AdultKatie Mills
COVID-19Pandemic Response RepositoryInfant, Preschool, ElementarySandy Grubbs
Dental Healthwater from Bottles to Establish Strong Teeth (waterBEST)InfantSonya K Capps
Dental HealthDental Anxiety in Young Dental PatientsPreschool, ElementaryNare Ghaltakhchyan
Developmental DisordersIBIS Early Prediction StudyInfant, PreschoolShannon Sweeney
Developmental DisordersRegistry for Autism, Fragile X Syndrome, and Intellectual and Developmental DisabilitiesInfant, Preschool, Elementary, Teen, AdultRenee Clark
Developmental DisordersFLASH StudyInfant, PreschoolJessica Steinbrenner
Developmental DisordersStudying brain development in infants with developmental disordersInfant, PreschoolJulia Gross
Developmental DisordersToddler Remote Assessment of Virtual Eye tracking and Language StudyInfant, Preschool, Elementary, Teen, AdultJessica Goldblum
DiabetesType 1 Diabetes RegistryInfant, Preschool, Elementary, Teen, AdultKlara Klein
DiabetesDeveloping treatments for type 1 diabetesElementary, Teen, AdultRoland Tisch
Down SyndromeIBIS Down Syndrome Imaging StudyInfant, PreschoolShannon Sweeney
Ear, Nose and Throat; Lungs and BreathingMapping the Pediatric Inhalation Interface: Nose, Mouth, and AirwaysInfant, Preschool, Elementary, TeenParis Bennett
Eating, Nutrition, and MetabolismARFID Genes and EnvironmentElementary, Teen, AdultMelissa Chernoff
EczemaEczema Research StudyElementary, Teen, AdultLauren Herlihy
Eosinophilic EsophagitisEoE Tooth Fairy Study: Environmental Risk Factors for Eosinophilic Esophagitis (EoE)Preschool, Elementary, Teen,Kacie Walker
Eosinophilic EsophagitisIndividualized Diet Elimintation for Treatment of Eosinophilic Esophagitis (EoE)Teen, AdultTim Gee
Eosinophilic Gastritis or GastroenteritisEosinophilic gastritis and gastroenteritis StudyTeen, AdultAriel Watts
Hereditary Hemorrhagic TelangiectasiaMulticenter study to learn more about brain avms and bleeding in people with Hereditary Hemorrhagic Telangiectasia (HHT)Infant, Preschool, Elementary, Teen, AdultKaren Smith
Inflammatory, Allergic, and Chronic Gastrointestinal DiseasesTissue Repository for Inflammatory & Allergic Chronic GI diseasesInfant, Preschool, Elementary, TeenAshley Wolber
Inflammatory Bowel DiseaseThe Pediatric IBD Network Improvement CollaborativePreschool, Elementary, Teen, AdultParis Bennett
Juvenile ArthritisInvestigating Biologic Drugs in Children with ArthritisInfant, Preschool, Elementary, Teen, AdultTeresa Dickson
Kidney DiseaseCureGN (Cure Glomerulonephropathy)Infant, Preschool, Elementary, Teen, AdultMaggie D'Angelo
Kidney DiseaseGDCN RegistryInfant, Preschool, Elementary, Teen, AdultKristin Brock
Kidney DiseaseEvaluating Problematic Proteinuria in Kids (EPPIK)Infant, Preschool, Elementary, TeenAnne Froment
LupusAurora VOCAL Study for Adolescents with Lupus NephritisTeenAnne Froment
Medication and Vaccine EfficacyPharmacokinetics and Safety of Drugs in Lactating Women and Breastfed InfantsInfant, Teen, AdultJennifer Talbert
Medication and Vaccine EfficacyPharmacokinetics of Off Label Pediatric MedicationsInfant, Preschool, ElementaryJennifer Talbert
Medication and Vaccine EfficacySafety of Sildenafil in Premature Infants (SIL02)InfantJennifer Talbert
Medication and Vaccine EfficacyPharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS or POP02)Infant, Preschool, Elementary, Teen, AdultJennifer Talbert
Mental and Emotional HealthLatina Mother and Child Immune Health StudyPreschool, AdultRebeca Alvarado Harris
Multiple ScelrosisPediatric Relapsing Remitting Multiple Sclerosis StudyElementary, Teen, AdultPatricia Orozco
NeurodevelopmentGenetic Determinants of Neurological and Developmental DisordersInfant, Preschool, Elementary, Teen, AdultSheila Joshi
NeurodevelopmentPediatric Brain Imaging StudyInfant, Preschool, ElementaryJordan Jimenez
NutritionInfant Nutrition & Cognition StudyInfant, AdultMelissa Shaffer
OsteoarthritisMove with Support - Muevete con ApoyoTeen, AdultSandra Soto
OsteomyelitisCHronic nonbacterial Osteomyelitis International Registry (CHOIR)Infant, Preschool, Elementary, Teen, AdultTeresa Dickson
PIK3CA Related Overgrowth SyndromesPIK3CA Related Overgrowth Syndromes (PROS) Clinical TrialElementary, Teen, AdultJulie Blatt
Sickle Cell DiseaseEarly Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell TransplantationPreschool, ElementaryKimberly Kasow
Sickle Cell DiseaseSTRIDE BiorepositoryTeen, AdultKimberly Kasow
Speech TherapySpeech Therapy Device StudyElementary, Teen, AdultLynn Fox
Speech, Dentofacial AbnormalitiesOrthognathic Speech Pathology: Phonetic Contrasts of Patients With Dental Discrepancies Pre- and Post-Treatment Analyses (OSP)Teen, AdultSherrill Phillips