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Request for Applications


As part of the mission of the Children’s Research Institute (CRI) to coordinate and support pediatric research, we are thrilled to announce 3 research funding opportunities:

  • Carolina For the Kids (CFTK) Research Grant Awards
  • UNC Children’s Development Early Career Investigator Grants
  • IQVIA Pediatric Clinical Scholars Award

The deadline for the CFTK Research Grant Awards and the UNC Children’s Development Early Career Investigator Grants has been extended to Monday, December 14, 2020. The IQVIA Scholar Award is not accepting applications for the 2020 cycle.

Funding Sources and Eligibility

Applicants for CRI Research Grant Initiative Awards must be a faculty member at UNC Children’s Hospital, or be a current fellow in good standing within UNC Children’s Hospitals, pursuing pediatric research.

Carolina For The Kids (CFTK), a UNC student-led organization, raises funds through donations and events, including their annual dance marathon. In addition to their primary mission of providing emotional, medical, and financial support for the patients and families served by UNC Children’s Hospital, CFTK supports a Research Grant Program. This program prioritizes clinical/translational research projects focused on children’s health. This mechanism supports early career and established faculty investigators (CFTK Faculty Investigator Award), as well as fellows (CFTK Fellows Award). Projects primarily or wholly based at UNC are prioritized.

CFTK Faculty Investigator Award

  • Anticipated awards: Up to 2.
  • Projected Maximum Award Amount: $40,000.
  • Eligibility: There are 3 categories for the CFTK Faculty Investigator Award:
    • Early career faculty investigators who have not previously competed successfully for an NIH-supported research project, specifically Assistant Professors or Instructors who are generating preliminary data for an extramural grant application.
    • Established faculty investigators with a track record of NIH funding and scholarly productivity in need of bridge funding (investigator salary support is not covered). Investigators who have submitted an NIH grant that received positive reviews but was not funded are eligible. The application must include the review summary statement, responses to noted weaknesses, and plan for resubmission.
    • Established faculty investigators who are expanding or redirecting research activities toward a new extramural funding opportunity.
  • Requirements: Applications must present a clear research proposal and a plan for subsequent extramural funding. It is expected that an extramural grant application will be submitted within 6 months of the completion of the CFTK Research proposal.

CFTK Fellows Award

  • Anticipated awards: Up to 2.
  • Project Maximum Award Amount: $5,000.
  • Eligibility: Fellows in a pediatric training program performing research with a child health focus.
  • Requirements: Fellows must identify a mentor who is committed to project and financial oversight and will work closely with the fellow on project design, execution and presentation/publication. The application must include a mentor’s letter of support (which articulates the mentor’s engagement with the fellow and project) and biosketch. Faculty mentors partnering with fellows will assume responsibility for stewardship of funds and program compliance, including any issues following the fellow’s graduation or departure from the program. Signature documentation of this agreement is required and is part of the application.

This grant is funded by the UNC Children’s Health Foundation through fundraising and philanthropic donations. Oversight comes from the Department of Pediatrics Chair, Dr. Stephanie Davis. This grant supports the development of pediatric researchers to advance child health. In alignment with this mission, this mechanism supports early career investigators who perform pediatric-related research in basic, translational, or clinical research, domestically or abroad.

  • Anticipated awards: Up to 2.
  • Project Maximum Award Amount: $10,000.
  • Eligibility: Early career faculty at the rank of Assistant Professor performing pediatric research.
  • Requirements: This award is intended to support a research project spearheaded by an early career investigator working with guidance of an identified senior faculty mentor. Proposed projects can include ancillary projects to already established or planned (funded) research protocols, stand-alone research projects, or projects with a quality improvement focus (as long as special consideration is given towards plans for publication). The application must include the mentor’s letter of support (which articulates the mentor’s engagement with the mentee and project) and biosketch. Plans and considerations for leveraging the products of the proposed work for the pursuit of future extramural funding are highly encouraged.

IQVIA, formerly Quintiles and IMS Health, Inc, integrates advances in data science and technology with human science expertise to help people in healthcare make better decisions and advance human health. To aid in the development of the next generation of physician-researchers, the IQVIA Pediatric Clinical Scholar’s Award supports an early career clinical investigator (Assistant Professor) focused on the advancement of children’s health through the development of new treatments.

  • Anticipated awards: Up to 1.
  • Projected Maximum Award amount: Up to $50,000 each year for up to 3 years, contingent upon progress as determined from applicant annual progress report and CRI Review Committee review and approval, for a total of up to $150,000.
  • Eligibility: Early career faculty at the rank of Assistant Professor performing pediatric clinical research.
  • Requirements: Support from this award is intended to be used by the awardee(s) to support human subjects research and clinical trial readiness studies generating results relevant for use in a clinical trial. This includes research projects that generate preliminary data, ancillary studies stemming from larger ongoing clinical trials, or pilot feasibility studies to explore the potential for future clinical trials and secure additional funding opportunities.
Proposal Review, Scoring and Feedback

The Review Process
The Review Committee will be comprised of Department of Pediatrics and North Carolina Children’s Hospital faculty members. Each proposal will be assigned to a primary and secondary reviewer, whose research aligns with the proposed study. Final funding decisions will be made in conjunction with the funders.

Reviewers will use the NIH-based criteria below to evaluate and generate an overall score for the proposal:

  • Applicant eligibility for the award category.
  • Significance: What is the problem/barrier the proposal seeks to address? If the aims of the proposal are achieved, how will scientific knowledge, technical capability, or clinical practice be improved and how will this advance the overall field?
  • Approach: Is the hypothesis valid (is the rationale and any supporting evidence sound)? Is the overall strategy, methodology, and/or proposed analyses well-reasoned and appropriate to address the specific aims? Are potential problems or alternative strategies appropriately discussed and addressed? What are the overall strengths and weaknesses of the proposal in terms of approach?
  • Innovation: Does the proposal challenge/propose refinements to current clinical, research, or theoretical paradigms? Does the proposal utilize novel concepts, approaches/methods, instrumentation, or interventions? What are the overall strengths and weaknesses of the innovative aspects of the proposal?
  • Specific Aims: Are they well supported by the rationale and evidence provided? Will they address the underlying hypothesis? Are they generally robust and feasible to achieve given the project’s timeline and resources?
  • Investigator qualifications: For established investigators, how does their experience, skills, and record lend themselves to what is proposed? For early career faculty, does the mentor or identified collaborative team meet qualifications in regards to accomplishing the goals of this proposal?
  • Potential for future funding.
  • Appropriate budget: Does it conform to the regulations of the funding announcement? Is it reasonable in light of the described approach and any additional resources available to the investigator(s)?
  • For current or prior CRI grant recipients, conforming to the requirements of past awards.

In addition, research projects involving human subjects will:

  • Provide sample size driven by biostatical-supported power calculations, or rationale as to why biostatistical calculations do not apply.
  • Demonstrate feasibility, including:
    • Study population (eg, commitment of clinics involved for potential recruitment, population numbers from i2b2 or Carolina Data Warehouse)
    • Resources for implementation, (eg, clinic availability, coordinator support)
    • Plan for human subjects/IRB approval

Reviewers will review and score the proposals. The primary reviewer will summarize the proposal with the scores, with additional input form the secondary reviewer, at an in-person meeting with the Review Committee, where all committee members will be asked to weigh-in and discuss the proposal.

Possible scores assigned to a faculty proposal:

  1. Approved for Consideration of Funding.
  2. Minor revisions (executive committee review).
  3. Major revisions (requires re-evaluation by the primary and secondary reviewers).
  4. Resubmit next deadline.
  5. Triaged; No resubmission will be accepted.

Possible scores assigned to a fellow proposal:

  1. Approved for Consideration of Funding.
  2. Considered for Funding after Revision (requires re-evaluation by the primary and secondary reviewers).
  3. Do Not Fund.

After the Review Committee meets, and upon potential further evaluation, the Review Committee will recommend each grant be either “Approved for Consideration of Funding” or “Not Approved for Consideration of Funding.” The Review Committee then presents these recommendations to the Review Executive Committee, who makes the final funding decision.

Feedback from the Review Committee
In order to provide ample feedback to PIs, applications will receive notification of the grant status following the Review Committee meeting and potential reevaluation. Along with notification that their grant was either approved or not approved for funding, applicants will receive the reviewer’s comments, the score from the Review Committee, and the priority score, approximately 6 months from submission.

Post Award Expectations and Responsibilities

Post Award Process & Financial Management

Following the notice of award, a specific start date will be established. Timelines for the funding period are set by each individual funding opportunity.

  • Carolina for the Kids Faculty and Fellow Research Grants: 18 months
  • UNC Children’s Development Early Career Investigator Grants: 18 months
  • IQVIA Pediatric Clinical Scholar Award: 12 months, renewable for up to 3 years

PIs will have from the date of award to complete their research, including time to receive regulatory and other approvals. Investigators will not have access to the funds until all appropriate University, IACUC, or IRB approvals have been received and the appropriate accounts are created by the UNC Department of Pediatrics financial data systems.

PIs are responsible for maintaining the necessary approvals and maintaining current certifications of training in research (IRB/OHRP, IUCUC, EHS, HIPPA, etc.). For faculty grants, extensions of up to one year may be allowed. Extensions require approval of the CRI.

Research Grant Account Reviews

Account reviews are mandatory, both after a time period of 12 months, and 3 months prior to the completion of the project. Any funds remaining in the project after the end of the funding period will be returned to the Grants program. If an extension was granted, additional account reviews will be required. Continued funding is contingent upon progress as determined from the recipient’s annual progress report and CRI Review Committee review and approval.

Grant Tracking Program

Awardees will be required to complete brief progress reports after 1 year, as well a final progress report to track milestones and progress of the research projects. The CRI will request updates on these plans and the success of any funding applications via a brief survey. Problems severely hampering the progress of the projects should be brought to the attention of the CRI as soon as possible, who will work with the awardees to try to address these issues. Failure to complete progress reports in a timely manner may result in early termination of a project and forfeiture of remaining funds.

All Research Grant awards will be entered into a tracking program to evaluate the productivity of investigators related to extramural funding applications, awards, publications and development. Grant and manuscript tracking of award productivity begins on the date of the award (account set-up date). Future Research Grant applications will have this tracking information made available to the reviewers and the Research Grants committee for consideration in their deliberations. Investigators that have successfully fulfilled the grant submission and publication requirements within the appropriate period of time will have this accomplishment highlighted during the application process for future Research Grant funding.

Citing the Research Grants

Carolina for the Kids Research Grant-supported researchers will acknowledge support from the Carolina for the Kids Research Grants program in their publications and presentations (e.g., “This research was supported, in part, by the Carolina For The Kids Grants Program.”)

UNC Children’s Development Early Career Researcher Grants will acknowledge support from the UNC Health Foundation in their publications and presentations (e.g., “This research was supported, in part, by a UNC Children’s Development Early Career Investigator grant through the generous support of donors to UNC.”)

IQVIA Scholars Award supported researchers will acknowledge support from IQVIA in their publications and presentations (e.g., “This research was supported, in part, by an IQVIA Scholars Award.”)

Online Application Components and Requirements

The deadline for the CFTK Research Grant Awards and the UNC Children’s Development Early Career Investigator Grants is Monday, December 14, 2020. The IQVIA Scholar Award is not accepting applications for the 2020 cycle.

The online application for all CRI Grant Initiative Awards can be found here. You will need to create an account with Foundant and submit your application online. You will select which CRI Grant Initiative Award you are applying for within the Foundant system. Each applicant may submit up to one proposal per funding mechanism per year. The system will permit one application per submission.

You will be asked to complete information to identify you, your research, and department. You will also be asked if your application underwent a design and statistical review prior to the submission deadline date, or an explanation why this was not performed. This may be performed by a fellow investigator, mentor, collaborator or biostatistician. Please be sure the study’s stated aims and the statistical analysis plans are consistent.

You will also be asked to upload:

Proposal Documents

Please upload in pdf format, using 0.5’’ margins, Arial font-11 point or larger. There are no restrictions on font color, although black/high-contrast colors are recommended. Font size for legends/figures should be no smaller than 9 point. Letters of Support do not need to conform to these formatting restrictions.

  • Cover letter (optional)
  • Abstract (1/2 page)
  • Specific Aims (1 page)
  • Project description (Limited to 2 pages)
  • Impact on career (faculty) or training (fellow) (1 page limit)
  • Timetable (1 page-describe the time from award to completion of milestones such as IRB approval, first patient enrolled, rate of anticipated patient enrollment, completion of specimen analysis or data acquisition, start and end of interim/final analyses)
  • Applicant Biosketch in NIH format
  • Faculty mentor Biosketch in NIH format (Fellows and Early Career Investigators)
  • Faculty Mentor Letter of Support (Fellows and Early Career Investigators only, see Additional Instructions below)
  • Division Chief Letter of Support (Faculty only)
  • Additional Letters of Support as needed from potential collaborators
  • Plans for submission/resubmission of proposal(s) for extramural funding resultant from the proposed work (1/2 page)
  • Budget (please download and use this budget template for your proposal)
  • Budget Justification
  • For Proposals that will support a resubmission of a favorably reviewed, but unfunded NIH application, applicants should provide the NIH review summary statement and submitted responses to noted weaknesses returned to the reviewers
Additional Instructions
Budget and Budget Justification

Many expenses may not be covered. Note: These lists are not necessarily all-inclusive. Please contact Pediatrics Accounting Administration with any questions about whether or not the Research funds cover any possible expense.

Approved Research Expenses:

  • Biostatistical support
  • Computer/software (with clear justification of why they are needed). Any information technology-related purchases deemed essential to the project by the awards committee must be approved by Department of Pediatrics IT. All hardware and software will be considered property of the Department. The Department will determine appropriate disposition of such items at the end of the project.
  • Equipment and supplies
  • Office supplies
  • Postage (for research-related mailings)
  • Publication costs of publishers (submit info from publisher)
  • Salary and fringe benefit (UNC faculty not allowed; other research positions may be allowed, but must be approved by PI’s department via the routing/signature process.)
  • Travel (not exceeding $1,000 for presentation of research at national meeting for PIs without other funds)

Not Approved Expenses:

  • Any expense not directly related to research activity
  • Any personal professional expense
  • Board exam fees
  • Board review courses
  • DEA#
  • Grant writing/editing for submissions, articles, etc.
  • Lab coats
  • Medical licenses
  • Membership dues to societies and professional organizations
  • Periodicals
  • Professional liability insurance
  • Subscriptions
  • Telephone and pager
  • Travel (unless PI has no funds)
Faculty Mentor Letter of Support (for mentored awards)

Assistant Professors and Fellows must apply with a faculty mentor. Faculty mentors partnering with fellows or early career investigators will assume responsibility for stewardship of funds and program compliance, including any issues remaining following the applicant’s graduation and departure from the University. Include in the Faculty Mentor Letter of Support:

  1. Mentor’s support and approval of the proposed research plan and commitment toward actively mentoring the applicant.
  2. Mentor’s agreement to fund stewardship and program compliance as described above.
  3. Mentor’s prior experience in mentoring trainees.
  4. Assurance of adequate time available from the mentor needed to oversee the project.
  5. Assurance that the applicant has access to adequate resources and/or equipment required to carry out the proposed work (for items not requested in the budget).
  6. A commitment by the mentor to help the fellow present or publish the research.
  7. An agreement by the mentor to ensure compliance with the reporting requirements described in Post Award Expectations and Responsibilities.

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