Department of Genetics faculty, postdocs, students and collaborators published ten papers during May 3-16, 2020.

 

Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose.
Wu P, Rybin D, Bielak LF, Feitosa MF, Franceschini N, Li Y, Lu Y, Marten J, Musani SK, Noordam R, Raghavan S, Rose LM, Schwander K, Smith AV, Tajuddin SM, Vojinovic D, Amin N, Arnett DK, Bottinger EP, Demirkan A, Florez JC, Ghanbari M, Harris TB, Launer LJ, Liu J, Liu J, Mook-Kanamori DO, Murray AD, Nalls MA, Peyser PA, Uitterlinden AG, Voortman T, Bouchard C, Chasman D, Correa A, de Mutsert R, Evans MK, Gudnason V, Hayward C, Kao L, Kardia SLR, Kooperberg C, Loos RJF, Province MM, Rankinen T, Redline S, Ridker PM, Rotter JI, Siscovick D, Smith BH, van Duijn C, Zonderman AB, Rao DC, Wilson JG, Dupuis J, Meigs JB, Liu CT, Vassy JL.
PLoS One. 2020 May 7;15(5):e0230815. doi: 10.1371/journal.pone.0230815. eCollection 2020.
PMID: 32379818

 

TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination.
Deng M, Tam JW, Wang L, Liang K, Li S, Zhang L, Guo H, Luo X, Zhang Y, Petrucelli A, Davis BK, Conti BJ, June Brickey W, Ko CC, Lei YL, Sun S, Ting JP.
Nat Commun. 2020 May 4;11(1):2193. doi: 10.1038/s41467-020-16014-0.
PMID: 32366851

 

Association test using Copy Number Profile Curves (CONCUR) enhances power in rare copy number variant analysis.
Brucker A, Lu W, Marceau West R, Yu QY, Hsiao CK, Hsiao TH, Lin CH, Magnusson PKE, Sullivan PF, Szatkiewicz JP, Lu TP, Tzeng JY.
PLoS Comput Biol. 2020 May 4;16(5):e1007797. doi: 10.1371/journal.pcbi.1007797. [Epub ahead of print]
PMID: 32365089

 

Combined associations of a polygenic risk score and classical risk factors with breast cancer risk.
Kapoor PM, Mavaddat N, Choudhury PP, Wilcox AN, Lindström S, Behrens S, Michailidou K, Dennis J, Bolla MK, Wang Q, Jung A, Abu-Ful Z, Ahearn T, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Auer PL, Freeman LEB, Becher H, Beckmann MW, Beeghly-Fadiel A, Benitez J, Bernstein L, Bojesen SE, Brauch H, Brenner H, Brüning T, Cai Q, Campa D, Canzian F, Carracedo A, Carter BD, Castelao JE, Chanock SJ, Chatterjee N, Chenevix-Trench G, Clarke CL, Couch FJ, Cox A, Cross SS, Czene K, Dai JY, Earp HS, Ekici AB, Eliassen AH, Eriksson M, Evans DG, Fasching PA, Figueroa J, Fritschi L, Gabrielson M, Gago-Dominguez M, Gao C, Gapstur SM, Gaudet MM, Giles GG, González-Neira A, Guénel P, Haeberle L, Haiman CA, Håkansson N, Hall P, Hamann U, Hatse S, Heyworth J, Holleczek B, Hoover RN, Hopper JL, Howell A, Hunter DJ; ABCTB Investigators; kConFab/AOCS Investigators, John EM, Jones ME, Kaaks R, Keeman R, Kitahara CM, Ko YD, Koutros S, Kurian AW, Lambrechts D, Marchand LL, Lee E, Lejbkowicz F, Linet M, Lissowska J, Llaneza A, MacInnis RJ, Martinez ME, Maurer T, McLean C, Neuhausen SL, Newman WG, Norman A, O’Brien KM, Olshan AF, Olson JE, Olsson H, Orr N, Perou CM, Pita G, Polley EC, Prentice RL, Rennert G, Rennert HS, Ruddy KJ, Sandler DP, Saunders C, Schoemaker MJ, Schöttker B, Schumacher F, Scott C, Scott RJ, Shu XO, Smeets A, Southey MC, Spinelli JJ, Stone J, Swerdlow AJ, Tamimi RM, Taylor JA, Troester MA, Vachon CM, van Veen EM, Wang X, Weinberg CR, Weltens C, Willett W, Winham SJ, Wolk A, Yang XR, Zheng W, Ziogas A, Dunning AM, Pharoah PDP, Schmidt MK, Kraft P, Easton DF, Milne RL, García-Closas M, Chang-Claude J.
J Natl Cancer Inst. 2020 May 2. pii: djaa056. doi: 10.1093/jnci/djaa056. [Epub ahead of print]
PMID: 32359158

 

Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders.
Byrne EM, Zhu Z, Qi T, Skene NG, Bryois J, Pardinas AF, Stahl E, Smoller JW, Rietschel M; Bipolar Working Group of the Psychiatric Genomics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Owen MJ, Walters JTR, O’Donovan MC, McGrath JG, Hjerling-Leffler J, Sullivan PF, Goddard ME, Visscher PM, Yang J, Wray NR.
Mol Psychiatry. 2020 May 12. doi: 10.1038/s41380-020-0705-9. [Epub ahead of print]
PMID: 32398722

 

Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer.
Carrot-Zhang J, Chambwe N, Damrauer JS, Knijnenburg TA, Robertson AG, Yau C, Zhou W, Berger AC, Huang KL, Newberg JY, Mashl RJ, Romanel A, Sayaman RW, Demichelis F, Felau I, Frampton GM, Han S, Hoadley KA, Kemal A, Laird PW, Lazar AJ, Le X, Oak N, Shen H, Wong CK, Zenklusen JC, Ziv E; Cancer Genome Atlas Analysis Network, Cherniack AD, Beroukhim R.
Cancer Cell. 2020 May 11;37(5):639-654.e6. doi: 10.1016/j.ccell.2020.04.012.
PMID: 32396860

 

Pharmacokinetic and pharmacodynamic analyses of cocaine and its metabolites in behaviorally divergent inbred mouse strains.
Zhu J, Beechinor RJ, Thompson T, Schorzman AN, Zamboni W, Crona DJ, Weiner DL, Tarantino LM.
Genes Brain Behav. 2020 May 8:e12666. doi: 10.1111/gbb.12666. [Epub ahead of print]
PMID: 32383297

 

Cognitive phenotype and differential gene expression in a hippocampal homologue in two species of frog.
Liu Y, Jones CD, Day LB, Summers K, Burmeister SS.
Integr Comp Biol. 2020 May 15. pii: icaa032. doi: 10.1093/icb/icaa032. [Epub ahead of print]
PMID: 32413121

 

Drosophila Histone Locus Body assembly and function involves multiple interactions.
Koreski KP, Rieder LE, McLain LM, Chaubal A, Marzluff WF, Duronio RJ.
Mol Biol Cell. 2020 May 13:mbcE20030176. doi: 10.1091/mbc.E20-03-0176. [Epub ahead of print]
PMID: 32401666

 

Comparison of Proteomic Assessment Methods in Multiple Cohort Studies.
Raffield LM, Dang H, Pratte KA, Jacobson S, Gillenwater L, Ampleford E, Barjaktarevic I, Basta P, Clish CB, Comellas AP, Cornell E, Curtis JL, Doerschuk C, Durda P, Emson C, Freeman C, Guo X, Hastie AT, Hawkins GA, Herrera J, Johnson WC, Labaki WW, Liu Y, Masters B, Miller M, Ortega VE, Papanicolaou G, Peters S, Taylor KD, Rich SS, Rotter JI, Auer P, Reiner AP, Tracy RP, Ngo D, Gerszten RE, Kay O’Neal W, Bowler RP; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium.
Proteomics. 2020 May 9:e1900278. doi: 10.1002/pmic.201900278. [Epub ahead of print]
PMID: 32386347