Department of Genetics faculty, postdocs, students and collaborators published 33 papers during August 31st – September 27th 2025.
Feasibility and clinical utility of expanded genomic newborn screening in the Early Check program.
Cope HL, Jalazo ER, Berg JS, Sullivan JA, Kucera KS, Shone SM, Frawley HE, Gwaltney AY, Forsythe AN, Migliore BA, Wright B, Moultrie RR, Milko LV, Zimmerman RS, Kruszka P, Suchy SF, Begtrup A, Langley KG, Monaghan KG, Kraczkowski C, Guenzel AJ, McWalter K, Hruska KS, Bailey DB Jr, Wheeler AC, Raspa M, Powell CM, Peay HL; Early Check Program.
Nat Med. 2025 Sep 5. doi: 10.1038/s41591-025-03945-8. Online ahead of print.
PMID: 40913169
Äijö T, Gioulbasani M, Valenzuela JE, Tsagaratou A.
Front Immunol. 2025 Aug 20;16:1638500. doi: 10.3389/fimmu.2025.1638500. eCollection 2025.
PMID: 40909275 Free PMC article.
Wenric S, Sangli C, Guittar J, Islam F, Zander A, Won Hyun S, Davison JM, Mayhew GM, Beebe K, Beauchamp K, Patel M, Brown K, Chen J, Nimeiri H, Milburn MV, Perou CM, Guinney J, Taxter TJ, Benson A 3rd.
JCO Precis Oncol. 2025 Sep;9:e2500197. doi: 10.1200/PO-25-00197. Epub 2025 Sep 4.
PMID: 40906989
Wolter JM, James LM, Boeshore SL, Mao H, McCoy ES, Ryan DF, Fragola G, Taylor-Blake B, Stein JL, Zylka MJ.
Commun Biol. 2025 Sep 2;8(1):1332. doi: 10.1038/s42003-025-08794-2.
PMID: 40897812 Free PMC article.
Conserved mycobacterial sRNA B11 regulates lipooligosaccharide synthesis at posttranscriptional level in Mycobacterium marinum.
Wang C, Bei C, Fan Y, Liu Q, Ding Y, Takiff HE, Gao Q.
mLife. 2025 Aug 25;4(4):447-460. doi: 10.1002/mlf2.70025. eCollection 2025 Aug.
PMID: 40893975 Free PMC article.
Hutchins EK, Niu C, Xue J, Wan D, Campos CV, Warren M, Knuth MM, Whalen MB, Voruganti VS, Agoro R, Fleet JC, Hammock BD, Ideraabdullah F.
Endocrinology. 2025 Aug 29:bqaf138. doi: 10.1210/endocr/bqaf138. Online ahead of print.
PMID: 40884172
Krishnan M, Anwar MY, Justice AE, Chittoor G, Chen HH, Roshani R, Scartozzi A, Dickerson RR, Smit RAJ, Preuss MH, Chami N, Hadad BS, Parra EJ, Cruz M, Hui Q, Wilson PWF, Sun YV, Zhang X, Linchangco GV, Kardia SLR, Faul JD, Weir DR, Bielak LF, Highland HM, Young KL, Qi B, Wang Y, Fornage M, Haiman C, Cheng I, Peters U, Kooperberg C, Buyske S, McCormick JB, Fisher-Hoch SP, Lona-Durazo F, Peralta J, Gomez-Zamudio J, Rich SS, Ferrier KR, Lange EM, Gignoux CR, Kenny EE, Wojcik GL, Cho K, Gaziano MJ, Djousse L, Liu S, Vaidya D, de Mutsert R, Josyula NS, Bauer CR, Zhao W, Walker RW, Smith JA, Lange LA, Meyer MC, Liu CT, Yanek LR, Lee M, Raffield LM, Loos RJF, Gordon-Larsen P, Below JE, North KE, Graff M.
PLoS Genet. 2025 Sep 12;21(9):e1011842. doi: 10.1371/journal.pgen.1011842. Online ahead of print.
PMID: 40939575
Shwetar YJ, Haendel MA.
Transl Vis Sci Technol. 2025 Sep 2;14(9):17. doi: 10.1167/tvst.14.9.17.
PMID: 40938069
Sneddon TP, Melville SA, Xiong M, Foss K, Cardwell EB, Rafferty K, Weck KE, Berglind A, Heinzen EL, Tedder ML, Gucsavas-Calikoglu M, Shiloh-Malawsky Y, Fan ZJ, Powell BC, Hunter SE.
Am J Med Genet A. 2025 Sep 11:e64249. doi: 10.1002/ajmg.a.64249. Online ahead of print.
PMID: 40931928
Schichlein KD, Masood S, Kim HH, Hawley B, Ghosh A, Samet JM, Porter NA, Smith GJ, Jaspers I.
Am J Physiol Lung Cell Mol Physiol. 2025 Sep 12. doi: 10.1152/ajplung.00233.2025. Online ahead of print.
PMID: 40938902
Yousaf H, de Koning MA, Khan K, Gilmore KL, Hoffer MJV, Kellaris G, Lanone S, Dagouassat M, Ullah F, Adama van Scheltema PN, Heron D, Capri Y, Kuechler A, Schweiger B, Haak MC, Keren B, Tran Mau Them F, Peeters-Scholte CMPCD, Kaiser FJ, Koopmann TT, Mei H, Yalcin B, Depienne C, Vora NL, Santen GWE, Davis EE.
Am J Hum Genet. 2025 Sep 9:S0002-9297(25)00325-8. doi: 10.1016/j.ajhg.2025.08.015. Online ahead of print.
PMID: 40930097
Selvaraj MS, Li X, Li Z, Van Buren E, Haidermota S, Postupaka D, Hornsby W, Bis JC, Brody JA, Cade BE, Chung RH, Curran JE, Damrauer SM, de Las Fuentes L, de Vries PS, Duggirala R, Freedman BI, Graff M, Guo X, Hidalgo BA, Hou L, Irvin R, Judy R, Kalyani RR, Kelly TN, Konigsberg IR, Kral BG, Kwee LC, Levy D, Li C, Manichaikul AW, Martin LW, Montasser ME, Morrison AC, Naseri T, North KE, O’Connell JR, Palmer ND, Peyser PA, Reiner AP, Shah SH, Smit RAJ, Smith JA, Taylor KD, Tiwari H, Tsai MY, Viali S, Wang Z, Wang Y, Zhao W, Arnett DK, Blangero J, Boerwinkle E, Bowden DW, Carlson JC, Chen YI, Ellinor PT, Fornage M, He J, Heard-Costa N, Kaplan RC, Kardia SLR, Kooperberg C, Kraus WE, Lange LA, Loos RJF, Mitchell BD, Psaty BM, Rader DJ, Redline S, Rich SS, Yanek LR, Gibbs R, Gabriel S, Viaud-Martinez KA, Dutcher SK, Germer S, Kim R, Rotter JI, Lin X, Peloso GM; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Natarajan P.
Genome Biol. 2025 Sep 9;26(1):273. doi: 10.1186/s13059-025-03698-0.
PMID: 40926209 Free PMC article.
Hoesterey DT, Dang H, Markovic D, Buhr RG, Tashkin DP, Barr RG, Belperio JA, Bowler RP, Bleecker ER, Couper DJ, Criner GG, Cooper CB, Doerschuk CM, Dransfield MT, Drummond MB, Fawzy A, Freeman CM, Han MK, Hansel NN, Hastie AT, Hoffman EA, Huang YJ, Kaner RJ, Kanner RE, Kim V, Krishnan JA, Martinez FJ, O’Neal WK, Ortega VE, Paine R 3rd, Shrivastav AK, Wells JM, Woodruff PG, Curtis JL, Barjaktarevic I.
Ann Am Thorac Soc. 2025 Sep 8. doi: 10.1513/AnnalsATS.202412-1265OC. Online ahead of print.
PMID: 40920896
Wynn J, Rego S, Chandler-Brown D, Carter R, Talati A, Zaretsky M, Trimble A.
J Cyst Fibros. 2025 Sep 6:S1569-1993(25)01563-2. doi: 10.1016/j.jcf.2025.08.004. Online ahead of print.
PMID: 40915877
Zhang BC, Pedersen A, Reinert LS, Li Y, Narita R, Idorn M, Hu L, Skouboe MK, Li S, Maimaitili M, Ding X, Cong Y, Zhao J, Frémond ML, Mikkelsen K, Gao Z, Huang JR, Thomsen EA, Mikkelsen JH, Venkatraman R, Thomsen MK, Iversen MB, Assil S, Zhang R, Henneman L, Jakobsen MR, Oxvig C, Dalgaard TS, Møller P, Fago A, Wang T, Andersen CBF, De Nardo D, Reggiori F, Ting JP, Mikkelsen JG, Bak RO, Mogensen TH, Li P, Paludan SR.
Nat Immunol. 2025 Sep 19. doi: 10.1038/s41590-025-02283-8. Online ahead of print.
PMID: 40973797
Wang N, Ockerman FP, Zhou LY, Grove ML, Alkis T, Barnard J, Bowler RP, Clish CB, Chung S, Drzymalla E, Evans AM, Franceschini N, Gerszten RE, Gillman MG, Hutton SR, Kelly RS, Kooperberg C, Larson MG, Lasky-Su J, Meyers DA, Woodruff PG, Reiner AP, Rich SS, Rotter JI, Silverman EK, Vasan RS, Weiss ST, Wong KE, Wood AC, Wu L; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Yarden R, Blackwell TW, Smith AV, Chen H, Raffield LM, Yu B.
Am J Hum Genet. 2025 Sep 18:S0002-9297(25)00356-8. doi: 10.1016/j.ajhg.2025.08.022. Online ahead of print.
PMID: 40972578
Misumi I, Li Y, Shirasaki T, Yang L, Kapustina M, Lemon SM, Whitmire JK.
J Virol. 2025 Sep 19:e0139525. doi: 10.1128/jvi.01395-25. Online ahead of print.
PMID: 40970716
Xiong C, Huang S, Zhou M, Zhang Y, Wu W, Li X, Yao H, Chen J, Li Y.
Brief Bioinform. 2025 Aug 31;26(5):bbaf471. doi: 10.1093/bib/bbaf471.
PMID: 40966657
Blouin T, Ampolini E, Stayer K, Suresh P, Mieczkowski PA, Saini N.
Nucleic Acids Res. 2025 Sep 5;53(17):gkaf914. doi: 10.1093/nar/gkaf914.
PMID: 40966511 Free PMC article.
Li X, Wood AR, Yuan Y, Zhang M, Huang Y, Hawkes G, Beaumont RN, Weedon MN, Li W, Li X, Lin X, Li Z.
Cell Genom. 2025 Sep 18:101009. doi: 10.1016/j.xgen.2025.101009. Online ahead of print.
PMID: 40972583
Schroeder A, Loth ML, Luo C, Yao S, Yan H, Zhang D, Piya S, Plowey E, Hu W, Clemenceau JR, Jang I, Kim M, Barnfather I, Chan SJ, Reynolds TL, Carlile T, Cullen P, Sung JY, Tsai HH, Park JH, Hwang TH, Zhang B, Li M.
Nat Methods. 2025 Sep;22(9):1911-1922. doi: 10.1038/s41592-025-02770-8. Epub 2025 Sep 15.
PMID: 40954300 Free PMC article.
Kakar A, Litkowski EM, Scadden AW, Anwar MY, Konigsberg IR, Stanislawski MA, DuPre NC, Mitra R, Baumgartner R, Raffield LM, Lange EM, Lange LA, Taylor KC.
BMC Nephrol. 2025 Sep 26;26(1):524. doi: 10.1186/s12882-025-04425-4.
PMID: 41013308
Xu H, Gupta S, Dinsmore I, Kollu A, Cawley AM, Anwar MY, Chen HH, Petty LE, Seshadri S, Graff M, Below JE, Brody JA, Chittoor G, Fisher-Hoch SP, Heard-Costa NL, Levy D, Lin H, Loos RJF, Mccormick JB, Rotter JI, Mirshahi T, Still CD, Destefano A, Cupples LA, Mohlke KL, North KE, Justice AE, Liu CT.
Int J Obes (Lond). 2025 Sep 26. doi: 10.1038/s41366-025-01898-z. Online ahead of print.
PMID: 41006818
O’Neil ST, Schilder BM, Schaper K, Cox C, Korn D, Gehrke S, Mungall CJ, Haendel MA.
Bioinformatics. 2025 Sep 26:btaf549. doi: 10.1093/bioinformatics/btaf549. Online ahead of print.
PMID: 41002262
Gower G, Pope NS, Rodrigues MF, Tittes S, Tran LN, Alam O, Cavassim MIA, Fields PD, Haller BC, Huang X, Jeffrey B, Korfmann K, Kyriazis CC, Min J, Rebollo I, Rehmann CT, Small ST, Smith CCR, Tsambos G, Wong Y, Zhang Y, Huber CD, Gorjanc G, Ragsdale AP, Gronau I, Gutenkunst RN, Kelleher J, Lohmueller KE, Schrider DR, Ralph PL, Kern AD.
Mol Biol Evol. 2025 Sep 25:msaf236. doi: 10.1093/molbev/msaf236. Online ahead of print.
PMID: 40994024
Sun Q, Li Y.
Nat Rev Genet. 2025 Sep 24. doi: 10.1038/s41576-025-00895-2. Online ahead of print.
PMID: 40993437 Review.
Sarnowski C, Zhang Y, Ammous F, Shade LMP, DiCorpo D, Jian X, Arnett DK, Austin TR, Beiser A, Bis JC, Blangero J, Boerwinkle E, Bressler J, Curran JE, DeCarli CS, Doddapaneni H, Dupuis J, Fardo DW, Florez JC, Gabriel S, Gibbs RA, Glahn DC, Gupta N, González HM, González KA, Hatzikotoulas K, Hayden KM, Heckbert SR, Hidalgo B, Huerta-Chagoya A, Hughes TM, Kardia SLR, Kooperberg CL, Launer LJ, Longstreth WT Jr; T2DGGI consortium; MAGIC consortium; Mandla R, Mathias RA, Morris AP, Mosley TH, Nasrallah IM, Nyquist P, Psaty BM, Qi Q, Raffield LM, Rayner NW, Reiner AP, Satizabal CL, Selvin E, Sevilla-Gonzalez MDR, Smith AV, Smith JA, Smith K, Snively BM, Southam L, Sofer T, Suzuki K, Taylor HJ, Udler MS, Viaud-Martinez KA, Wassertheil-Smoller S, Wood AC, Yanek LR, Yin X, Manning AK, Rotter JI, Rich SS, Meigs JB, Fornage M, Seshadri S, Morrison AC; TOPMed Diabetes working group; and the TOPMed Neurocognitive working group.
Commun Biol. 2025 Sep 24;8(1):1352. doi: 10.1038/s42003-025-08674-9.
PMID: 40993182 Free PMC article.
Wilson EP, Broadaway KA, Parsons VA, Vadlamudi S, Narisu N, Brotman SM, Currin KW, Stringham HM, Erdos MR, Welch R, Holtzman JK, Lakka TA, Laakso M, Tuomilehto J, Boehnke M, Koistinen HA, Collins FS, Parker SCJ, Scott LJ, Mohlke KL.
Am J Hum Genet. 2025 Sep 23:S0002-9297(25)00359-3. doi: 10.1016/j.ajhg.2025.09.003. Online ahead of print.
PMID: 40992379
Ongoing evolution of PE/PPE genes in Mycobacterium tuberculosis associated with drug resistance and host immune response.
Gan M, Wang D, Li S, Wang Q, Liu Q.
mSystems. 2025 Sep 22:e0089825. doi: 10.1128/msystems.00898-25. Online ahead of print.
PMID: 40980874
Sylvester PA, Heise MT.
Annu Rev Virol. 2025 Sep;12(1):401-419. doi: 10.1146/annurev-virology-100422-031014. Epub 2025 May 6.
PMID: 40327531 Review.
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4.
Alicea Pauneto CDM, Riesenberg BP, Gandy EJ, Kennedy AS, Clutton GT, Hem JW, Hurst KE, Hunt EG, Green JM, Miller BC, Angus SP, Johnson GL, Esther RJ, Guerriero JL, Gao P, Soto-Pantoja DR, Ferris RL, Modliszewski JL, Coleman MF, Chung HK, Milner JJ, Moschos SJ, Wiseman RL, Thaxton JE.
Immunity. 2025 Sep 25:S1074-7613(25)00414-5. doi: 10.1016/j.immuni.2025.09.003. Online ahead of print.
PMID: 41005293
Galteau ME, Broadwater M, Chen Y, Desrosiers-Gregoire G, Gil R, Kaesser J, Kim E, Kıryağdı P, Lambers H, Liu YY, López-Gil X, MacNicol E, Mohebkhodaei P, De Oliveira RXN, Pereira CA, Reimann HM, Rivera-Olvera A, Selingue E, Sirmpilatze N, Strobelt S, Sumiyoshi A, Tham C, Tudela R, Vrooman RM, Wank I, Zhang Y, van Engelenburg WA, Baudewig J, Boretius S, Cash D, Chakravarty MM, Chuang KH, Ciobanu L, Devenyi GA, Faber C, Hess A, Homberg JR, Jelescu IO, Justicia C, Kawashima R, Niendorf T, Scheenen TWJ, Shemesh N, Soria G, Todd N, Wachsmuth L, Yu X, Zhang BB, Shih YI, Lee SH, Grandjean J.
Imaging Neurosci (Camb). 2025 Sep 22;3:IMAG.a.157. doi: 10.1162/IMAG.a.157. eCollection 2025.
PMID: 40995458 Free PMC article.
Schworer SA, Murano H, Dang H, Markovetz MR, Saito M, Kato T, Asakura T, Chen G, Gilmore RC, Morton LC, van Heusden C, Chua M, Strickler E, Wisniewski ZY, Crisp G, Mitchell E, Doherty KA, Mastan S, Trejo Bittar HE, Cody BA, Trudeau JB, De la Cruz G, Ralph LM, Askin FB, Panettieri RA Jr, Koziol-White CJ, Byrd KM, Livraghi-Butrico A, O’Neal WK, Randell SH, Wenzel SE, Okuda K, Boucher RC Jr.
Am J Respir Crit Care Med. 2025 Sep 23. doi: 10.1164/rccm.202409-1849OC. Online ahead of print.
PMID: 40986379