Grand Rounds – Tolerogenic Vaccination as a Myelin-Specific Therapy for Autoimmune Demyelinating Disease of the CNS

Tolerogenic Vaccination as a Myelin-Specific Therapy for Autoimmune Demyelinating Disease of the CNS

Mark D. Mannie, PhD

The Brody School of Medicine
East Carolina University

Objectives:

• Describe experimental strategies of tolerogenic vaccination for induction of FOXP3⁺ regulatory T cells.
• Discuss properties by which cytokines IFN-β and GM-CSF can be used to drive regulatory T cell responses.
• Explain mechanisms of ‘infectious’ tolerance regarding induction of polyclonal tolerance to the CNS.

February 2, 2017, 8 – 9 am
CG222, Sanofi-Aventis Conference Center, NCCH Room #1

Sponsored by the School of Medicine of The University of North Carolina at Chapel Hill.