UNC Lineberger’s Michael J. Emanuele, PhD, and colleagues have identified a key activator that can turn on FoxM1, a protein that drives expression of genes that help cells replicate and divide, a finding they published in the journal Molecular and Cellular Biology. They also discovered, paradoxically, that the activator for FoxM1 is also responsible for turning this protein off.
Disrupted signaling pathways that lead to aberrant cell movement are a hallmark of invasive and metastatic cancers. The small GTPase RhoA has a well-established role in normal cell biology, but the consequences of cancer-associated RhoA mutations are unknown. Devon will extensively characterize the effect of these mutations on the properties of RhoA in order to better understand how mutations in RhoA contribute to cancer
We welcome ten new students who are joining the Pharmacology PhD Program!
Congratulations to Angelina Vaseva, PhD, postdoctoral fellow in Channing Der’s lab, for being recognized with an American Association for Cancer Research (AACR) 2017 Women in Cancer Research Scholar Award! Vaseva received the award at the AACR annual meeting April 1-5. 2017 in Washington, DC. “My career goal is to become an independent investigator leading research … Read more
Get to know our eight new Carolina Summer Fellowship students who’ll be arriving in May!
Congratulations to James Shellhammer who successfully defended his thesis March 27, 2017!
Congratulations to Peyton Bohnsack, who successfully defend his PhD March 23, 2017!
Researchers in the department of Pharmacology link orphan receptor MRGRPX2 to opioid-induced itching and create a tool to study the receptor more precisely.
For the first time, UNC School of Medicine researchers crystalized the structure of LSD attached to a human serotonin receptor of a brain cell, and they may have discovered why an “acid trip” lasts so long.
UNC Lineberger researchers find how triple negative breast cancer cells are able to bypass treatment with trametinib, an FDA-approved drug. The researchers also used lab models of breast cancer to test a potential treatment approach that could prevent resistance.
