Authors: Rui Ye, Christopher P. Selby, Nuri Ozturk, Yunus Annayev and Aziz Sancar
Journal: The Journal of Biological Chemistry
Issue: July 22, 2011 - 286, 25891-25902
On The Cover: The circadian clock is the internal timekeeping molecular system that generates a daily rhythm in an organism's physiology and behavior. Based on genetic and cell biological experiments, a canonical model for the circadian clock in mammals consisting of TTFL has been developed. The paper by Rui Ye and colleagues describes the purification of the mammalian clock proteins and the first biochemical test of the model. Their findings support some aspects of the canonical model but also suggest that some key features of the model need to be revised. The cover picture is a whimsical illustration of the significance of biochemical analysis to the understanding of this complex behavioral system.