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Circadian control of skin cancer. Image courtesy of Marian Miller (University of Cincinnati, Cincinnati, OH). Upper left quadrant: Hourtide by Edward Henry Potthast, 1920; Lower left quadrant: Sleeping Woman by Felix Valloton, 1899.
Authors: Shobhan Gaddameedhi, Christopher P. Selby, William K. Kaufmann, Robert C. Smart, and Aziz Sancar
Journal: Proceedings of the National Academy of Sciences
Issue: November 15, 2011 - vol. 286, no. 46, 18567-18568
About the Article: The authors exposed two groups of mice to UV radiation—one at 4 AM and the other at 4 PM—and monitored the onset of skin cancer. Mice irradiated when the repair activity was at its lowest developed tumors much faster and at fivefold higher frequency compared with mice exposed to UV when the protein's repair function was at full throttle. When the authors repeated the experiment in a strain of mice lacking two key components of the circadian clock, the time of UV exposure tracked neither the protein's repair activity nor the onset of skin cancer, suggesting that circadian control of the XPA protein might influence skin cancer rates. Because mouse and human circadian clocks are similar, the time of UV exposure might likewise determine its cancer-causing potential in people, according to the authors.