The UNC High Throughput Peptide Synthesis and Array Facility offers researchers with high quality services for synthesis, purification, and characterization of synthetic peptides and preparation of custom designed peptide arrays.
This new core facility uses automated Fmoc Solid Phase Peptide Synthesis (SPPS) to make synthetic peptides, particularly specializing in synthesis of multiply modified peptides containing PTMs, unnatural amino acids, and fluorescent tags. They have the capability to synthesize mid size libraries of crude peptides (~100 peptides in 2-3 weeks) and can print peptide microarrays (up to 4000 spots per slide) from synthesized peptides. The facility can also make Multiple Antigenic Peptides (MAPs) for polyclonal antibodies generation.
The core facility director is research assistant professor Dr. Krzysztof Krajewski and the faculty director/oversight is associate professor Dr. Brian Strahl, both of whom hold appointments in the Department of Biochemistry and Biophysics.