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Edgar Faison professional photo from a graduation

Grad student Edgar Faison and Zhang lab collaborated with Dr. Ramamoorthy’s group at the University of Michigan to use polymer nanodiscs as a novel alignment medium for measuring residual dipolar couplings on RNA. 


KrishnarjunaBankala †, Thirupathi Ravula †, Edgar M. Faison †, Marco Tonelli, Qi Zhang, and Ayyalusamy Ramamoorthy. 2022. “Polymer-Nanodiscs as a Novel Alignment Medium for High-Resolution NMR-Based Structural Studies of Nucleic Acids” Biomolecules 12, no. 11: 1628. https://doi.org/10.3390/biom12111628  

† = These authors contributed equally to this work. 

Here, Zhang lab collaborated with Dr. Ramamoorthy’s group at the University of Michigan to use polymer nanodiscs as a novel alignment medium for measuring residual dipolar couplings on RNA. Residual dipolar couplings are an NMR observable that reports on the relative orientation of internuclear bond vectors irrespective of distance. This new technology facilitates the collection of this powerful and sometimes tediously wrought information. The Ramamoorthy group developed and characterized the alignment medium and Zhang lab provided an NMR sample of a model system we have extensively characterized, the fluoride riboswitch aptamer, and conducted the RDC analysis and benchmarking.  

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Zhang lab Research specialty: Molecular basis of RNA function

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