The American Cancer Society (ACS) is the nationwide, community-based, voluntary health organization dedicated to eliminating cancer as a major health problem by preventing cancer, saving lives and diminishing suffering from cancer through research, education, advocacy, and service.
ACS Postdoctoral Fellowships provide up to three years of initial funding to support training of researchers interested in an independent career in cancer research (including basic, preclinical, clinical, cancer control, psychosocial, behavioral, epidemiology, health services and health policy research). During the second or third year of the award, ACS Postdoctoral Fellows are invited to attend a Fellows Symposium to present their work, meet with senior leaders in cancer research, and develop additional professional skills important in their transition to independent research careers.
Dr. Rothbart is currently a postdoctoral fellow training in the lab of Dr. Brian Strahl, associate professor of Biochemistry and Biophysics. Dr. Rothbart's research focuses on the regulation of chromatin-templated biological processes by the 'histone code'. Particularly, he is interested in the biochemistry and biology of a chromatin-interacting protein, UHRF1, as a bridging molecule at the interface of histone post-translational modifications and DNA methylation.
For this project titled "Deciphering histone and protein codes in response to DNA damage", Dr. Rothbart aims to advance our understanding of the role of post-translational modification 'codes' on histones and the tumor suppressor protein p53 in DNA damage signaling and repair.