The objective of the NIH Pathway to Independence Award (K99/R00) is to help outstanding postdoctoral researchers complete needed training and transition to an independent tenure-track or equivalent faculty position. The awards are highly competitive and are usually funded for five years. Dr. Rothbart is currently a postdoctoral fellow training in the lab of Dr. Brian Strahl, associate professor of Biochemistry and Biophysics. Dr. Rothbart's research efforts focus on the regulation of chromatin-templated biological processes by the 'histone code'. Particularly, he is interested in the biochemistry and biology of a chromatin-interacting protein, UHRF1, as a bridging molecule at the interface of histone post-translational modifications and DNA methylation. With this K99 award, Dr. Rothbart will extend his studies on "Mechanisms Regulating DNA Methylation Maintenance in Chromatin." Funding for the award begins in February 2014 and will support his transition from a mentored research environment in the Strahl lab to establishing his own independent laboratory.