Congratulations to Wolfgang Bergmeier, Ph.D., Professor, Department of Biochemistry and Biophysics, in collaboration with a multi-institutional team, for publishing article in the journal Science Advances.
Dr. Bergmeier and the team explain why platelet responses are associated with organ injury and mortality after cardiac surgeries and how platelets cause local and systemic inflammation via mast cell activation.
Their research, titled “Platelets Trigger Perivascular Mast Cell Degranulation To Cause Inflammatory Responses and Tissue Injury”, was published in the March 18, 2020 edition of Science Advances and can be read online now:
ONLINE ARTICLE https://advances.sciencemag.org/content/6/12/eaay6314
Platelet responses have been associated with end-organ injury and mortality following complex insults such as cardiac surgery, but how platelets contribute to these pathologies remains unclear. Our studies originated from the observation of microvascular platelet retention in a rat cardiac surgery model. Ensuing work supported the proximity of platelet aggregates with perivascular mast cells (MCs) and demonstrated that platelet activation triggered systemic MC activation.
We then identified platelet activating factor (PAF) as the platelet-derived mediator stimulating MCs and, using chimeric animals with platelets defective in PAF generation or MCs lacking PAF receptor, defined the role of this platelet-MC interaction for vascular leakage, shock, and tissue inflammation. In application of these findings, we demonstrated that inhibition of platelet activation in modeled cardiac surgery blunted MC-dependent inflammation and tissue injury. Together, our work identifies a previously undefined mechanism of inflammatory augmentation, in which platelets trigger local and systemic responses through activation of perivascular MCs.