UNC School of Medicine scientists led by Nikolay Dokholyan, Michael Hooker Distinguished Professor of Biochemistry and Biophysics, add to evidence that small aggregates of SOD1 protein are the brain-cell killing culprits in ALS, but the formation of larger, more visible, and fibril-like aggregates of the same protein may protect brain cells.

Nikolay Dokholyan, Ph.D., shake hands with Armenian President Serzh Sargsyan.

Nikolay Dokholyan, Ph.D. from Biochemistry/Biophysics and Alexander "Sasha" Kabanov, Ph.D. from Pharmacology met with the President of Armenia on Nov. 8, 2017.

From a new study published in Structure, researchers in the lab of Nikolay Dokholyan have discovered a way to protect neurons from toxic effects by countering the tendency of the protein SOD1 to clump in motor neurons.

For the first time, scientists pin down the structure of toxic clumps of a protein associated with a large number of ALS cases, opening new avenues in the pursuit of drugs to stem the disease.

Tag: Dokholyan_news

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Dokholyan Meets with President of Armenia

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