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UNC Genetics PublicationsDepartment of Genetics faculty, postdocs, students and collaborators published 12 papers during December 17th 2023 – January 6th 2024.


Association of PIK3CA Mutation With Pathologic Complete Response and Outcome by Hormone Receptor Status and Intrinsic Subtype in Early-Stage ERBB2/HER2-Positive Breast Cancer. 

Zagami P, Fernandez-Martinez A, Rashid NU, Hoadley KA, Spears PA, Curigliano G, Perou CM, Carey LA.

JAMA Netw Open. 2023 Dec 1;6(12):e2348814. doi: 10.1001/jamanetworkopen.2023.48814.

PMID: 38117494 Free PMC article.


Consideration of the Beneficiary Inducement Statute on Access to Health Care Systems’ Population Genetic Screening Programs. 

Washington AM, Foss K, Krause JH, Davis AM, Kuczynski KJ, Milko LV, Berg JS, Roberts MC.

Public Health Genomics. 2023;26(1):183-187. doi: 10.1159/000534365. Epub 2023 Sep 29.

PMID: 37778346 Free PMC article. No abstract available.


Sex Differences in Mouse Cardiac Electrophysiology Revealed by Simultaneous Imaging of Excitation-Contraction Coupling. 

Emerson JI, Ariel P, Shi W, Conlon FL.

J Cardiovasc Dev Dis. 2023 Nov 29;10(12):479. doi: 10.3390/jcdd10120479.

PMID: 38132647


The interaction effects of age, APOE and common environmental risk factors on human brain structure. 

Chen J, Li T, Zhao B, Chen H, Yuan C, Garden GA, Wu G, Zhu H.

Cereb Cortex. 2023 Dec 18:bhad472. doi: 10.1093/cercor/bhad472. Online ahead of print.

PMID: 38112569


Liver integrity and the risk of Alzheimer’s disease and related dementias. 

Lu Y, Pike JR, Hoogeveen RC, Walker KA, Raffield LM, Selvin E, Avery CL, Engel SM, Mielke MM, Garcia T, Palta P.

Alzheimers Dement. 2023 Dec 28. doi: 10.1002/alz.13601. Online ahead of print.

PMID: 38153336


Molecular and Metabolic Analysis of Arsenic-Exposed Humanized AS3MT Mice. 

Todero J, Douillet C, Shumway AJ, Koller BH, Kanke M, Phuong DJ, Stýblo M, Sethupathy P.

Environ Health Perspect. 2023 Dec;131(12):127021. doi: 10.1289/EHP12785. Epub 2023 Dec 27.

PMID: 38150313 Free PMC article.


Stressful life events, social support, and epigenetic aging in the Women’s Health Initiative. 

Skinner HG, Palma-Gudiel H, Stewart JD, Love SA, Bhatti P, Shadyab AH, Wallace RB, Salmoirago-Blotcher E, Manson JE, Kroenke CH, Belsky DW, Li Y, Whitsel EA, Zannas AS.

J Am Geriatr Soc. 2023 Dec 27. doi: 10.1111/jgs.18726. Online ahead of print.

PMID: 38149693


High-throughput PRIME-editing screens identify functional DNA variants in the human genome. 

Ren X, Yang H, Nierenberg JL, Sun Y, Chen J, Beaman C, Pham T, Nobuhara M, Takagi MA, Narayan V, Li Y, Ziv E, Shen Y.

Mol Cell. 2023 Dec 21;83(24):4633-4645.e9. doi: 10.1016/j.molcel.2023.11.021.

PMID: 38134886


Centromere-Proximal Suppression of Meiotic Crossovers in Drosophila is Robust to Changes in Centromere Number, Repetitive DNA Content, and Centromere-Clustering. 

Pazhayam NM, Frazier LK, Sekelsky J.

Genetics. 2023 Dec 27:iyad216. doi: 10.1093/genetics/iyad216. Online ahead of print.

PMID: 38150397


On Robustness of Individualized Decision Rules. 

Qi Z, Pang JS, Liu Y.

J Am Stat Assoc. 2023;118(543):2143-2157. doi: 10.1080/01621459.2022.2038180. Epub 2022 Apr 11.

PMID: 38143785


A histone deacetylase network regulates epigenetic reprogramming and viral silencing in HIV-infected cells. 

Peterson JJ, Lewis CA, Burgos SD, Manickam A, Xu Y, Rowley AA, Clutton G, Richardson B, Zou F, Simon JM, Margolis DM, Goonetilleke N, Browne EP.

Cell Chem Biol. 2023 Dec 21;30(12):1617-1633.e9. doi: 10.1016/j.chembiol.2023.11.009.

PMID: 38134881 Free PMC article.


ACE configurator for ELISpot: optimizing combinatorial design of pooled ELISpot assays with an epitope similarity model. 

Lee JS, Karthikeyan D, Fini M, Vincent BG, Rubinsteyn A.

Brief Bioinform. 2023 Nov 22;25(1):bbad495. doi: 10.1093/bib/bbad495.

PMID: 38180831