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Zhichuan Zhu

1 year ago

Researchers publish in Advanced Science: Innate immunity-independent STING function is identified as a vulnerability in kidney cancer

First author postdoc Zhichuan Zhu PhD, Liu lab, Jean Cook, and collaborators publish in Advanced Science available online Nov. 29, 2022 "STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity." STING was identified in 2008 as a critical innate immune sensor to antagonize viral/bacterial infection. Inactivation of STING especially by epigenetic silencing has been shown to facilitate tumor progression. Efforts from various UNC and BCBP labs have recently identified an innate immunity-independent function of STING in kidney cancer that can be explored as a potential therapeutic target in treating kidney cancer...